This study examines EU chemical management regimes with a focus on the treatment of uncertainty. Referring to current discourses on sustainability, the study criticizes existing practices and discusses alternative approaches to chemical management. In addition to highly discussed options for management under conditions of uncertainty (e.g., precautionary management and adaptive management), we argue that chemical management might also benefit from introducing the "sufficiency" concept into the production context. More generally, this would entail a shift in seeing quality of life as based on a sufficiency rather than an abundance of chemicals. The article concludes that, although these chemical management ideas might be very problematic, more integrated and holistic visions of future chemical and environmental policies might emerge from considering new sustainability ideas in various branches of the current economic system.