In Indigenous and rural communities of the Global South, relationships between humans, water, and life are understood and organized in various ways, with water often viewed as intrinsically linked to land. These resources not only serve the tangible purpose of supporting livelihoods but also form a fundamental basis for intangible aspects such as culture, identity, and epistemic-ontological foundations. In this article, the interconnected rights to both water and land for these communities are conceptualized as "hydro-territorial rights" (HTRs). This concept encompasses the formal and/or customary norms and practices related to the ownership, access, control, and use of both land and water, which are regarded as interrelated entities. Theoretically, this article draws on rights-based critical institutionalism and political ecology approaches to natural resource governance, including the legal-pluralist distinction between de jure rights on paper and de facto rights in practice. The aim is to identify and comparatively analyze contentious situations and conflicts surrounding water and land rights in rural Indigenous contexts across three postcolonial settings in the Global South. Methodologically, we employ a comparative strategy based on theory and literature reviews to examine conflictual hydro-territorial rights situations within selected Indigenous localities in Bolivia, India, and Tanzania. This analysis is complemented by interviews with local actors and observations in these three settings. Among our findings, we highlight both conflicts and temporary alliances between local and external interests, as well as practices and mechanisms related to the colonial legacy. We also explore how contemporary capitalist developmental interventions in these areas have impacted communities' access to and rights over local water and land resources, resulting in significant consequences for local livelihoods and ethno-cultural-territorial identities.