Water resources in India are projected to face severe climate-induced stress. In the North-Eastern Hill region, where lifestyles are closely connected to nature, this holds great implications for human development. While scientific knowledge regarding climate change and water is growing at global and regional scales, an equally diverse body of knowledge on the human dimensions of the same at local levels is weak. This article attempts to bridge this knowledge gap by presenting micro-level evidence on the gendered impact of increasing water stress and the innovative gendered local adaptive strategies in this region. It urges for the need to re-think on adaptation planning, basing it on local templates for greater sustainability.