This study examines how personality, gender, and age interact with experienced work-related exhaustion in Stockholm County. Using a quantitative cross-sectional design, data were collected through an online questionnaire targeted at employed individuals in the Stockholm area. A total of 111 participants completed self-report questionnaires, and the participants assessed their characteristics based on the Big Five Inventory-2 (BFI-2) and reported their levels of exhaustion using the Maslach Burnout Inventory (MBI). The results revealed that neuroticism is strongly associated with an increased risk of exhaustion, while other personality traits such as extraversion, conscientiousness and agreeableness may serve as protective factors. The study also identified gender differences, with women reporting higher levels of exhaustion. Additionally, age was found to be a significant factor, with younger participants exhibiting a greater risk of experiencing exhaustion symptoms. Combining Big Five assessments with self-report measures of exhaustion can help identify individual risks and guide preventive actions. Understanding these factors allows both individuals and organizations to promote sustainable work environments and reduce the risk of burnout.