sh.sePublications
Change search
Refine search result
1 - 2 of 2
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • harvard-anglia-ruskin-university
  • apa-old-doi-prefix.csl
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Gurajada, Deepthi
    Södertörn University College, School of Life Sciences.
    Transplantation of Human Embryonic Stem Cells to a damaged Human Cornea an in vitro study2010Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Corneal dystrophies are commonly referred to as an congenital condition. Surgical complications are usually worse then the primary dysfunction and patients need to go through large surgical process. Only 25 % of the patients reach driving licence vision after a surgery. The aim of this study was to investigate if the application of human embryonic stem cells (hESc) could replace epithelial cells of the human cornea. Corneal markers such as cytokeratins CK3, CK15, CK19 and Pax - 6 were analysed by immunohistochemistry. HES - Cellect was used as indication of  stem cell potential of the transplanted cells. hESc transplanted onto the cornea could be seen to attach and expand dominantly  towards Bowman’s membrane. Human embryonic stem cells in culture were relatively positive for markers, contradictionally stem cells  in the epithelial trails lost their stem differentiation  potential  and appeared to be negative for all markers used in these trails. Optimization of stem cells differentiation into epithelial which may in the future may gives us the ability to perform clinical applications with successful outcome.

  • 2.
    Kitambi, Satish Srinivas
    et al.
    Södertörn University, School of Life Sciences. Karolinska Institute.
    Chandrasekar, Gayathri
    Södertörn University, School of Life Sciences. Karolinska Institute.
    Addanki, Vamsi Krishna
    Teleost fish - Powerful models for studying development, function and diseases of the human eye2011In: Current Science, ISSN 0011-3891, Vol. 100, no 12, p. 1815-1823Article in journal (Refereed)
    Abstract [en]

    The human eye is a highly specialized structure and defects in its development or functioning process have an impact on the quality of life. Different animal models, especially murine models, have been used to identify the key molecular players required for the normal functioning of the eye. This review highlights the importance of the teleost model in dissecting the development, functioning process and diseases of the human eye. A high degree of conservation is seen in the development, organization and function of the eye throughout vertebrates. Vertebrate teleost models, zebrafish and medaka, have become popular to study various aspects of developmental biology and genetics. Teleost eye shows high similarity to that of the mammalian eye; for example, as seen in mammals, the retina of zebrafish and medaka shows six types of neurons and one type of glia arranged in three layers. In addition, rapid embryonic development, transparency during early development, and the availability of various biochemical, molecular and genetic techniques applicable on these models facilitate in dissecting the developmental and functioning processes of the eye. The availability of mutants with eye defects in zebrafish and medaka allows the possibility of utilizing these two species as comparative models in gaining rapid understanding of the developmental events of various human diseases. The small size of these fish embryos and their availability in large numbers allow performing medically relevant chemical screens to identify potential drug and/or drug targets for different human eye conditions.

1 - 2 of 2
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • harvard-anglia-ruskin-university
  • apa-old-doi-prefix.csl
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf