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  • 351.
    Xue-Franzen, Yongtao
    et al.
    Södertörn University, School of Life Sciences, Molecular biology. Karolinska Institutet.
    Johnsson, Anna
    Södertörn University, School of Life Sciences, Molecular biology. Karolinska Intitutet.
    Brodin, David
    Karolinska Institutet.
    Henriksson, Johan
    Södertörn University, School of Life Sciences, Molecular biology. Karolinska Institutet.
    Bürglin, Thomas R.
    Södertörn University, School of Life Sciences, Molecular biology. Karolinska Institutet.
    Wright, Anthony P. H.
    Södertörn University, School of Life Sciences, Molecular biology. Karolinska Institutet.
    Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles2010In: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 11, article id 200Article in journal (Refereed)
    Abstract [en]

    Background: Gcn5 is a transcriptional coactivator with histone cetyltransferase activity that is conserved with regard to structure as ell as its histone substrates throughout the eukaryotes. Gene egulatory networks within cells are thought to be evolutionarily iverged. The use of evolutionarily divergent yeast species, such as S. erevisiae and S. pombe, which can be studied under similar nvironmental conditions, provides an opportunity to examine the nterface between conserved regulatory components and their cellular pplications in different organisms. esults: We show that Gcn5 is important for a common set of stress esponses in evolutionarily diverged yeast species and that the activity f the conserved histone acetyltransferase domain is required. We define group of KCl stress response genes in S. cerevisiae that are pecifically dependent on Gcn5. Gcn5 is localised to many Gcn5-dependent enes including Gcn5 repressed targets such as FLO8. Gcn5 regulates ivergent sets of KCl responsive genes in S. cerevisiae and S. pombe. enome-wide localization studies showed a tendency for redistribution of cn5 during KCl stress adaptation in S. cerevisiae from short genes to he transcribed regions of long genes. An analogous redistribution was ot observed in S. pombe. onclusions: Gcn5 is required for the regulation of divergent sets of Cl stress-response genes in S. cerevisiae and S. pombe even though it s required a common group of stress responses, including the response o KCl. Genes that are physically associated with Gcn5 require its ctivity for their repression or activation during stress adaptation, roviding support for a role of Gcn5 as a corepressor as well as a oactivator. The tendency of Gcn5 to re-localise to the transcribed egions of long genes during KCl stress adaptation suggests that Gcn5 lays a specific role in the expression of long genes under adaptive onditions, perhaps by regulating transcriptional elongation as has been een for Gcn5 in S. pombe. Interestingly an analogous redistribution of cn5 is not seen in S. pombe. The study thus provides important new nsights in relation to why coregulators like Gcn5 are required for the orrect expression of some genes but not others.

  • 352.
    Zaman, Muhammad Haidar
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Improvement in Hepatitis “C” viral infection with advanced antiviral therapy,treatment – a meta-analysis2015Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Hepatitis is the inflammation of liver and there are many reasons of hepatitis. Among these reasons the viral hepatitis due to hepatitis B virus (HBV) and hepatitis C Virus (HCV) are the common hepatic infections and the major causes of liver cancer and liver cirrhosis in the world especially in Asia and Medal east. HBV and HCV infections are having very high mortality ratio in Europe and every year millions of people become infected and die due to HBV or HCV in Europe and Worldwide. That’s why viral hepatitis needs a serious consideration and perfect treatment.

    Objective: Objective of the study was to analyze the role of ribavirin in HCV treatment and to observe the virological response and relapse against it by using statistical meta-analytical techniques.

    Selection criteria and data collection: For this meta-analysis I used the publication databases PubMed, ScienceDirect and Google Scholar to collect all research articles describing treatment and response of HCV and using the antiviral drugs Ledipasvir and Sofosbuvir (control group) in combination with the active agent Ribavirin.

    Method and Methodology: Meta-analysis was performed using the statistical package R and the package metafore.

    Result and conclusion: The result shows that the use of ribavirin with control group (ledipasvir and sofosbuvir) did not show a significant impact on the sustained virological response (SVR) during and after treatment. But addition of ribavirin in control group effectively reduced the rate of relapse after treatment.

  • 353.
    Åhlin, Erik
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Tuberculosis care in Stockholm: An organizational analysis based on staff perception2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In an increasingly more interconnected world, the importance of epidemiology in public and international health is rapidly increasing. Tuberculosis is one of the diseases that contributes to this, as its lengthy incubation time and annual high mortality count makes it one of the toughest bacteria for the medical community to combat. Sweden is today a low-endemic region but still suffers a number of cases each year. The majority of these infections have occurred abroad.

    This qualitative study aims evaluate the Swedish healthcare systems organizational structure in relation to the treating and tracking of tuberculosis. Key personnel from several different units working with diagnosing, treating and tracking of tuberculosis have been interviewed about their perception regarding the organizational structure. The data have been analyzed through H. Mintzbergs theoretical framework regarding organizational structure. The analysis shows that the current system can be described as an Adhocracy. The organization is highly capable of handling adjustment and producing unique and complex outputs in the form of individualized treatment plans and disease tracking efforts. However, the system is highly dependent on internal communication and has great difficulty in up-scaling and expanding. The study shows that the current system would be challenged by a sharp increase in tuberculosis-cases in Stockholm.

  • 354. Öberg, Lisa
    Barnmorskan och läkaren - kompetens och konflikt i svensk förlossningsvård 1870-19201996Doctoral thesis, monograph (Other academic)
  • 355.
    Öberg, Lisa
    Södertörn University, Avdelning 1, Centre for Studies in Practical Knowledge.
    Luktsinnet i arbetet2003In: Öppna doftsinnet!: dokumentation av seminarium om människans doftsinne, januari 2003, Örebro: Örebro universitet , 2003Conference paper (Other academic)
  • 356.
    Öberg, Lisa
    Södertörn University, Institutionen för medier, konst och filosofi, Centre for Studies in Practical Knowledge.
    Näsans kunskap: Om luktsinnet i arbetsliv, vetenskap och konst2004Collection (editor) (Other academic)
    Abstract [sv]

    Lukter och dofter är gåtfulla - mäktiga men undflyende. En doft avklingar snabbt, även om luktämnet finns kvar i luften, men intrycken lever kvar i vårt inre. Luktsinnet hjälper oss att finna mat och dryck och kärlek, men de dofter som leder oss låter sig ogärna fångas i ord.

    Luktsinnet har betraktats som primitivt, djuriskt. Det förekommer sällan i vetenskapliga studier.

    I Näsans kunskap lyfter fem forskare fram luktsinnet från dess undanskymda plats. De kommer från vitt sklida ämnesområden: konst och litteratur, arbetsliv och yrkeskunnande, filosofi och psykologi. Här presenteras också sensoriken, den vetenskap som utforskar just lukt och smak.

  • 357.
    Öberg, Lisa
    Södertörn University, Avdelning 3, History.
    Så sannt mig Gud hjelpe til lif och själ: Om läkareden i Sverige förr och nu2000In: Människan i historien och samtiden: festskrift till Alf W Johansson, Stockholm: Hjalmarson & Högberg , 2000, p. 289-309Chapter in book (Other academic)
  • 358.
    Öberg, Lisa
    Södertörn University, Avdelning 3, History.
    Varför svär inte svenska läkare ed?2001In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 98, no 37, p. 3935-3937Article in journal (Refereed)
  • 359.
    Öberg, Lisa
    Södertörn University, School of Historical and Contemporary Studies, History. Södertörn University, School of Culture and Education, Teacher Education.
    With an eye to the future2013In: 300 years in the service of life: The Swedish association of midwives / [ed] Margareta Rehn, Donald Boström, Stockholm: Svenska barnmorskeförbundet , 2013, 1, p. 61-64Chapter in book (Other (popular science, discussion, etc.))
  • 360.
    Öhrming, Jan
    Södertörn University College, School of Business Studies, Business studies.
    Hälso- och sjukvårdens fragmentering: från lokalt till transnationellt organiserad sjukvård2008 (ed. 1)Book (Other academic)
  • 361.
    Öhrming, Jan
    Södertörn University College, School of Business Studies, Business studies.
    Sjukvårdens fragmentering och entreprenörerna2008In: Perspektiv på förnyelse och entreprenörskap i offentlig verksamhet / [ed] Anders Lundström, Elisabeth Sundin, Örebro: Forum för småföretagarforskning , 2008, Vol. S. 55-71, p. 55-71Chapter in book (Other academic)
  • 362.
    Öhrming, Jan
    et al.
    Södertörn University, Avdelning 4, Business studies.
    Sverke, Magnus
    Andemeningen är bra, men...: kvalitetsfrågans betydelse för vårdens arbetsmiljö och organisation2002In: Kvalitet utan gränser: en kritisk belysning av kvalitetsstyrning / [ed] Eva Bejerot, Hans Hasselbladh, Lund: Academia Adacta , 2002, 1, Vol. S. 188-208, 54 ref., p. 188-208Chapter in book (Other academic)
  • 363.
    Öhrming, Jan
    et al.
    Södertörn University, Avdelning 4, Business studies.
    Sverke, Magnus
    Bolagiseringen av S:t Görans sjukhus: en proaktiv organisering2001Book (Other academic)
    Abstract [sv]

    Akut vård och akutsjukhus är ett av samhällets mest sammansatta servicesystem. Detta förhållande har alltmer uppmärksammats i skuggan av hälso- och sjukvårdens övergripande problem - de totala kostnaderna och finansieringen - vilka i början av 1990-talet framkallade en serie reformer inom landets landsting. Den kanske mest radikala åtgärden var bolagiseringen (1994) och sedermera privatiseringen (1999) av S:t Görans Sjukhus i Stockholm. Exemplet S:t Göran har också ansetts så framgångsrikt att det har följts av nya bolagiseringar och fr.o.m. årsskiftet 2000/2001 förväntas i stort sett all akutsjukvård i Stockholm bedrivas inom bolag. Detta till trots saknas nästan helt litteratur som analyserar denna unika utveckling.Denna bok skärskådar utvecklingen (1994 - 1999) inom S:t Görans Sjukhus AB (bolaget) respektive Södertälje Sjukhus (förvaltningen) - två akutsjukhus i Stockholm med olika driftsformer, varierande historia och olika förutsättningar att utnyttja de möjligheter som 1990-talet förde med sig. Boken tar upp hälso- och sjukvårdens effektivitet, lyfter fram osäkerhet som ett av de framträdande arbetsvillkoren för sjukvården och beskriver chefernas osäkerhet och i kontrast till denna läkarnas, sjuksköterskornas och undersköterskornas trygghet samt förklarar meningsskapandets (sensemaking) centrala betydelse i vården.

  • 364.
    Öhrming, Jan
    et al.
    Södertörn University, Avdelning 4, Business studies.
    Sverke, Magnus
    Transition towards privatization: uncertainty and sensemaking in two Swedish emergency hospitals2003In: New organizational challenges for human service work / [ed] Johnny Hellgren, München: Hampp , 2003, 1, Vol. S. 75-93, 46 ref., p. 75-93Chapter in book (Other academic)
5678 351 - 364 of 364
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  • modern-language-association-8th-edition
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  • Other style
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  • nn-NO
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