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  • 301.
    Svensson, Anna
    Södertörn University College, School of Discourse Studies.
    Inte bara piller: en artikelserie om äldredepression, om dem som drabbats och om vilken hjälp de får.2008Independent thesis Basic level (degree of Bachelor), 10 points / 15 hpStudent thesis
  • 302. Sverke, Magnus
    et al.
    Hellgren, Johnny
    Näswall, Katharina
    Göransson, Sara
    Öhrming, Jan
    Södertörn University, School of Business Studies, Business studies.
    Employee Participation in Organizational Change: Investigating the Effects of Proactive vs. Reactive Implementation of Downsizing in Swedish Hospitals2008In: Zeitschrift für Personalforschung, ISSN 0179-6437, E-ISSN 1862-0000, Vol. 22, no 2, p. 111-129Article in journal (Refereed)
    Abstract [en]

    Whereas employee participation is generally conceived to facilitate implementation of organizational change, only limited research has investigated whether it may reduce the negative effects of downsizing. The present study compares two Swedish hospitals that implemented downsizing in different ways. While there were no major differences in stressors between hospitals, proactive implementation was associated with more employee participation. Moreover, employee participation variables were positively associated with employee work attitudes and well-being at both hospitals. These findings provide insights concerning the importance of a long-term strategic implementation of organizational change.

  • 303. Sverke, Magnus
    et al.
    Hellgren, Johnny
    Öhrming, Jan
    Södertörn University, Avdelning 4, Business studies.
    Organizational restructuring and health care work: A quasi-experimental study1999In: Organizational psychology and health care: European contributions / [ed] Pascale M. Le Blanc, M.C.W. Peeters, A. Büssing, W.B. Schaufeli, München: Rainer Hampp Verlag , 1999, p. 15-32Chapter in book (Other academic)
  • 304.
    Syberyjski, Lukas
    Södertörn University College, School of Discourse Studies.
    Styrelseproffsen hotar idealisterna2008Independent thesis Basic level (degree of Bachelor), 10 points / 15 hpStudent thesis
  • 305.
    Tanaka, Hirokazu
    et al.
    Erasmus University Medical Center, Rotterdam, The Netherlands / University of Tokyo, Tokyo, Japan.
    Nusselder, Wilma J
    Erasmus University Medical Center, Rotterdam, The Netherlands.
    Bopp, Matthias
    University of Zürich, Zürich, Switzerland.
    Brønnum-Hansen, Henrik
    University of Copenhagen, Copenhagen, Denmark.
    Kalediene, Ramune
    Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Lee, Jung Su
    University of Tokyo, Tokyo, Japan.
    Leinsalu, Mall
    Södertörn University, School of Social Sciences, Sociology. Södertörn University, School of Social Sciences, SCOHOST (Stockholm Centre for Health and Social Change). National Institute for Health Development, Tallinn, Estonia.
    Martikainen, Pekka
    University of Helsinki, Helsinki, Finland.
    Menvielle, Gwenn
    Sorbonne Universités, Paris, France.
    Kobayashi, Yasuki
    University of Tokyo, Tokyo, Japan.
    Mackenbach, Johan P
    Erasmus University Medical Center, Rotterdam, The Netherlands.
    Mortality inequalities by occupational class among men in Japan, South Korea and eight European countries: a national register-based study, 1990–20152019In: Journal of Epidemiology and Community Health, ISSN 0143-005X, E-ISSN 1470-2738, Vol. 73, no 8, p. 750-758Article in journal (Refereed)
    Abstract [en]

    Background: We compared mortality inequalities by occupational class in Japan and South Korea with those in European countries, in order to determine whether patterns are similar.

    Methods: National register-based data from Japan, South Korea and eight European countries (Finland, Denmark, England/Wales, France, Switzerland, Italy (Turin), Estonia, Lithuania) covering the period between 1990 and 2015 were collected and harmonised. We calculated age-standardised all-cause and cause-specific mortality among men aged 35–64 by occupational class and measured the magnitude of inequality with rate differences, rate ratios and the average inter-group difference.

    Results: Clear gradients in mortality were found in all European countries throughout the study period: manual workers had 1.6–2.5 times higher mortality than upper non-manual workers. However, in the most recent time-period, upper non-manual workers had higher mortality than manual workers in Japan and South Korea. This pattern emerged as a result of a rise in mortality among the upper non-manual group in Japan during the late 1990s, and in South Korea during the late 2000s, due to rising mortality from cancer and external causes (including suicide), in addition to strong mortality declines among lower non-manual and manual workers.

    Conclusion: Patterns of mortality by occupational class are remarkably different between European countries and Japan and South Korea. The recently observed patterns in the latter two countries may be related to a larger impact on the higher occupational classes of the economic crisis of the late 1990s and the late 2000s, respectively, and show that a high socioeconomic position does not guarantee better health.

  • 306.
    Tasmin, Saira
    et al.
    University of Chicago, Chicago, IL, USA / University of Tokyo, Tokyo, Japan.
    Ng, Chris Fook Sheng
    University of Tokyo, Tokyo, Japan / Nagasaki University, Nagasaki, Japan.
    Stickley, Andrew
    Södertörn University, School of Social Sciences, SCOHOST (Stockholm Centre for Health and Social Change).
    Md, Nasiruddin
    Ministry of Environment and Forest, Dhaka, Bangladesh.
    Saroar, Golam
    Ministry of Environment and Forest, Dhaka, Bangladesh.
    Yasumoto, Shinya
    Ritsumeikan University, Kyoto, Japan.
    Watanabe, Chiho
    University of Tokyo, Tokyo, Japan / National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan.
    Effects of Short-term Exposure to Ambient Particulate Matter on the Lung Function of School Children in Dhaka, Bangladesh2019In: Epidemiology, ISSN 1044-3983, E-ISSN 1531-5487, Vol. 30, no Suppl 1, p. S15-S23Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Ambient particulate pollution may adversely affect children's lung function. However, evidence on this association remains scarce in Asia despite this region having the greatest burden of disease due to air pollution.

    OBJECTIVES: To investigate the effect of short-term exposure to ambient particulate matter (PM) on the lung function of school children in Dhaka city, Bangladesh. The possible seasonal modification of this association was also examined.

    METHODS: A panel of 315 school children who were 9-16 years of age were recruited from three schools in and around Dhaka. Lung function was assessed using a spirometry test during the cool and warm seasons in 2013, yielding six measurements per child. Daily PM data were retrieved from nearby air monitoring stations. Linear mixed effects models were used to examine associations. Seasonal modification was examined by stratification.

    RESULTS: An inverse association was observed for the lung function parameters with PM2.5; peak expiratory flow (PEF) and forced expiratory volume within 1 second (FEV1) decreased with increasing PM2.5. The percent deviation from the personal median was -4.19% [95% confidence interval (CI): -5.72, -2.66] for PEF and -2.05% (95% CI: -2.92, -1.18) for FEV1 for a 20 µg/m increase in PM2.5 on the previous day. Results for PM10 were less consistent. The estimated effects of PM on lung functions were generally greater in the warm season.

    CONCLUSIONS: Short-term exposure to PM is associated with worse lung function in children living in highly polluted settings, with the strength of these adverse PM effects varying by season.

  • 307.
    Tegnestedt, C.
    et al.
    Karolinska University Hospital.
    Gunther, A.
    Karolinska University Hospital / Karolinska Institutet.
    Reichard, A.
    Karolinska University Hospital.
    Bjurström, R.
    Alvarsson, Jesper
    Stockholms universitet, Psykologiska institutionen.
    Martling, C. -R
    Karolinska University Hospital / Karolinska Institutet.
    Sackey, P.
    Karolinska University Hospital / Karolinska Institutet.
    Levels and sources of sound in the intensive care unit - an observational study of three room types2013In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 57, no 8, p. 1041-1050Article in journal (Refereed)
    Abstract [en]

    Background: Many intensive care unit (ICU) patients describe noise as stressful and precluding sleep. No previous study in the adult setting has investigated whether room size impacts sound levels or the frequency of disruptive sounds. Methods: A-frequency S-time weighted equivalent continuous sound (L(AS)eq), A-frequency S-time weighted maximum sound level (L(AS)max) and decibel C peak sound pressure (L(C)peak) were measured during five 24-h periods in each of the following settings: three-bed room with nursing station (NS) alcove, single-bed room with NS alcove (1-BR with NSA) and single-bed room with bedside NS. Cumulative restorative time (CRT) (>5min with L(AS)max <55dB and L(C)peak <75dB) was calculated to describe calm periods. Two 8-h bedside observations were performed in each setting in order to note the frequency and sources of disruptive sounds. Results: Mean sound pressure levels (L(AS)eq) ranged between 52 and 58dBA, being lowest during night shifts. There were no statistically significant differences between the room types in mean sound levels or in CRT. However, disruptive sounds were 40% less frequent in the 1-BR with NSA than in the other settings. Sixty-four percent of disruptive sounds were caused by monitor alarms and conversations not related to patient care. Conclusions: Single-bed rooms do not guarantee lower sound levels per se but may imply less frequent disruptive sounds. Sixty-four percent of disruptive sounds were avoidable. Our findings warrant sound reducing strategies for ICU patients.

  • 308. Tiikkaja, Sanna
    et al.
    Hemström, Örjan
    Vågerö, Denny
    Intergenerational class mobility and cardiovascular mortality among Swedish women: a population-based register study2009In: Social Science and Medicine, ISSN 0277-9536, E-ISSN 1873-5347, Vol. 68, p. 733-739Article in journal (Refereed)
    Abstract [en]

    Class inequalities in cardiovascular disease (CVD) mortality are well documented, but the impact of intergenerational class mobility on CVD mortality among women has not been studied thoroughly. We examined whether women's mobility trajectories might contribute to CVD mortality beyond what could be expected from their childhood and adult social class position. The Swedish Work and Mortality Data Base provided childhood (1960) and adulthood (1990) social indicators. Women born 1945–59 (N = 791 846) were followed up for CVD mortality 1990–2002 (2019 deaths) by means of logistic regression analysis. CVD mortality risks were estimated for 16 mobility trajectories. Gross and net impact of four childhood and four adult classes, based on occupation, were analysed for mortality in ischemic heart disease (IHD), stroke, other CVD, – and all CVD. Differences between the two most extreme trajectories were 10-fold, but the common trajectory of moving from manual to non-manual position was linked to only a slight excess mortality (OR = 1.26) compared to the equally common trajectory of maintaining a stable non-manual position (reference category). Moving into adult manual class resulted in an elevated CVD mortality whatever the childhood position (ORs varied between 1.42 and 2.24). After adjustment for adult class, childhood class had some effect, in particular there was a low risk of coming from a self-employed childhood class on all outcomes (all ORs around = 0.80). A woman's own education had a stronger influence on the mortality estimates than did household income. Social mobility trajectories among Swedish women are linked to their CVD mortality risk. Educational achievement seems to be a key factor for intergenerational continuity and discontinuity in class-related risk of CVD mortality among Swedish women. However, on mutual adjustment, adult class was much more closely related to CVD mortality than was class in childhood.

  • 309. Tikka, Pia
    et al.
    Kaipainen, Mauri
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Media Technology.
    Embodied Protonarratives Embedded in Systems of Contexts: A Neurocinematic Approach2015In: Neuroscience and Media: New Understandings and Representations / [ed] Grabowski, Michael, Routledge, 2015, p. 76-88Chapter in book (Other academic)
  • 310. Tikka, Pia
    et al.
    Kaipainen, Mauri
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Media Technology.
    Phenomenological Considerations on Time Consciousness under Neurocinematic Search Light2014In: Cinéma & cie : international film studies journal, ISSN 2036-461X, Vol. XIV, no 22-23Article in journal (Refereed)
    Abstract [en]

    Film narratives are intrinsically time-dependent designs. This article proposes a model of narrative nowness, based on Husserl's concepts of retention and protention on one hand, and Francisco Varela's neurophenomenological exploration of time consciousness on the other, relating this further to narrative experience and its neural epiphenomena. Only recently has brain research been equipped with the possibility of dealing with temporal frames relevant for time consciousness in the scope of whole narratives. The study of cinema using neuroscientific methods and insights is referred to as neurocinematics. We promote neurocinematics as a complementary method of traditional film research, rather than an approach of brain sciences in general. Neurocinematic methods may provide film studies with new tools for re-evaluating established filmmaking conventions and developing new ways to study, for instance, the film viewer's experience and related aspects of time consciousness.

  • 311.
    Tikka, Pia
    et al.
    Aalto University, Finland .
    Kaipainen, Mauri Y.
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Media Technology.
    From naturalistic neuroscience to modeling radical embodiment with narrative enactive systems2014In: Frontiers in Human Neuroscience, ISSN 1662-5161, E-ISSN 1662-5161, Vol. 8, p. 794-Article in journal (Refereed)
    Abstract [en]

    Mainstream cognitive neuroscience has begun to accept the idea of embodied mind, which assumes that the human mind is fundamentally constituted by the dynamical interactions of the brain, body, and the environment. In today’s paradigm of naturalistic neurosciences, subjects are exposed to rich contexts, such as video sequences or entire films, under relatively controlled conditions, against which researchers can interpret changes in neural responses within a time window. However, from the point of view of radical embodied cognitive neuroscience, the increasing complexity alone will not suffice as the explanatory apparatus for dynamical embodiment and situatedness of the mind. We suggest that narrative enactive systems with dynamically adaptive content as stimuli,may serve better to account for the embodied mind engaged with the surrounding world. Among the ensuing challenges for neuroimaging studies is how to interpret brain data against broad temporal contexts of previous experiences that condition the unfolding experience of nowness. We propose means to tackle this issue, as well as ways to limit the exponentially growing combinatoria of narrative paths to a controllable number.

  • 312. Tikka, Pia
    et al.
    Väljamäe, Aleksander
    de Borst, Aline
    Pugliese, Roberto
    Ravaja, Niklas
    Kaipainen, Mauri
    Södertörn University, School of Communication, Media and it, Media technology.
    Takala, Tapio
    Enactive cinema paves way for understanding complex real-time social interaction in neuroimaging experiments2012In: Frontiers in Human Neuroscience, ISSN 1662-5161, E-ISSN 1662-5161, Vol. 6, article id 298Article in journal (Refereed)
    Abstract [en]

    We outline general theoretical and practical implications of what we promote as enactive cinema for the neuroscientific study of online socio-emotional interaction. In a real-time functional magnetic resonance imaging (rt-fMRI) setting, participants are immersed in cinematic experiences that simulate social situations. While viewing, their physiological reactions - including brain responses - are tracked, representing implicit and unconscious experiences of the on-going social situations. These reactions, in turn, are analysed in real-time and fed back to modify the cinematic sequences they are viewing while being scanned. Due to the engaging cinematic content, the proposed setting focuses on living-by in terms of shared psycho-physiological epiphenomena of experience rather than active coping in terms of goal-oriented motor actions. It constitutes a means to parametrically modify stimuli that depict social situations and their broader environmental contexts. As an alternative to studying the variation of brain responses as a function of a priori fixed stimuli, this method can be applied to survey the range of stimuli that evoke similar responses across participants at particular brain regions of interest.

  • 313.
    Tong, Yong-Guang
    et al.
    Södertörn University, School of Life Sciences, Molecular biology.
    Bürglin, Thomas R.
    Södertörn University, School of Life Sciences, Molecular biology.
    Conditions for dye-filling of sensory neurons in Caenorhabditis elegans2010In: Journal of Neuroscience Methods, ISSN 0165-0270, E-ISSN 1872-678X, Vol. 188, no 1, p. 58-61Article in journal (Refereed)
    Abstract [en]

    Dye-filling is a common method used to stain Caenorhabditis elegans ensory neurons in vivo. While the amphids and phasmids are easy to tain, a subset of sensory neurons, the IL2 neurons, are difficult to tain reproducibly. Here we examined the conditions under which the IL2 eurons take up the lipophilic fluorescent dye DiI. We find that IL2 ye-filling depends on salt concentration, but not osmolarity. Low salt rior and during incubation is important for efficient dye uptake. dditional parameters that affect dye-filling are the speed of shaking uring incubation and the addition of detergents. Our modified ye-filling procedure provides a reliable method to distinguish mutant lleles that stain amphids and phasmids, IL2 neurons, or both. An dditional benefit is that it can also stain the excretory duct. The ethod allows genetic screens to be performed to identify mutants that electively affect only one of the sensory structures or the excretory uct.

  • 314.
    Törning, Ulrica
    Södertörn University College, School of Discourse Studies.
    Sexualbrottslingen - monster eller människa?2006Independent thesis Basic level (degree of Bachelor), 10 points / 15 hpStudent thesis
    Abstract [sv]

    Lås in pedofilerna och kasta bort nyckeln. Tvångskastrera våldtäktsmännen. Samhällets dom mot sexualbrottslingarna är hård och vägen tillbaka för många omöjlig.

    Möt sexualbrottslingen och de som arbetar med män vars handlingar väcker avsky.

  • 315.
    Vals, Kaire
    et al.
    University of Tartu, Tartu, Estonia / National Institute for Health Development, Tallinn, Estonia.
    Kiivet, Raul-Allan
    University of Tartu, Tartu, Estonia.
    Leinsalu, Mall
    Södertörn University, School of Social Sciences, Sociology. Södertörn University, School of Social Sciences, SCOHOST (Stockholm Centre on Health of Societies in Transition). National Institute for Health Development, Tallinn, Estonia.
    Alcohol consumption, smoking and overweight as a burden for health care services utilization: a cross-sectional study in Estonia2013In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 13, article id 772Article in journal (Refereed)
    Abstract [en]

    Background: Alcohol consumption, smoking and weight problems are common risk factors for different health problems. We examine how these risk factors are associated with the use of health care services.

    Methods: Data for 6500 individuals in the 25-64 age group came from three cross-sectional postal surveys conducted in 2004, 2006, and 2008 in Estonia. The effect of alcohol consumption, smoking and weight problems on the use of primary and specialist care services, hospitalizations and ambulance calls was analysed separately for men and women by using binary logistic regression.

    Results: Overweight and/or obesity were strongly related to the use of primary care and out-patient specialist services for both genders, and to hospitalizations and ambulance calls for women. Current smoking was related to ambulance calls for both genders, whereas smoking in the past was related to the use of primary care and specialist services among men and to hospitalizations among women. Beer drinking was negatively associated with all types of health care services and similar   association was found between wine drinking and hospitalizations. Wine drinking was positively related to specialist visits. The frequent drinking of strong alcohol led to an increased risk for ambulance calls. Drinking light alcoholic drinks was positively associated with all types of health care services (except ambulance calls) among men and with the use of specialist services among women.

    Conclusions: Overweight and smoking had the largest impact on health care utilization in Estonia. Considering the high prevalence of these behavioural risk factors, health policies should prioritize preventive programs that promote healthy lifestyles in order to decrease the disease burden and to reduce health care costs.

  • 316. Van der Heyden, J H A
    et al.
    Schaap, Maartje M.
    Kunst, Anton E.
    Esnaola, Santiago
    Borrell, Carme
    Cox, B
    Leinsalu, Mall
    Södertörn University, School of Social Sciences, Sociology. Södertörn University, School of Social Sciences, SCOHOST (Stockholm Centre on Health of Societies in Transition). National Institute for Health Development, Tallinn, Estonia.
    Stirbu, Irina
    Kalediene, Ramune
    Deboosere, Patrik
    Mackenbach, Johan P.
    Van Oyen, H
    Socioeconomic inequalities in lung cancer mortality in 16 European populations.2009In: Lung Cancer, ISSN 0169-5002, E-ISSN 1872-8332, Vol. 63, no 3, p. 322-330Article in journal (Refereed)
    Abstract [en]

    Important socioeconomic inequalities exist in lung cancer mortality in Europe. They are consistent with the geographical spread of the smoking epidemic. In the next decades socioeconomic inequalities in lung cancer mortality are likely to persist and even increase among women. In Southern European countries we may expect a reversal from a positive to a negative association between socioeconomic status and lung cancer mortality. Continuous efforts are necessary to tackle socioeconomic inequalities in lung cancer mortality in all European countries.

  • 317. Van Raalte, AA
    et al.
    Kunst, AE
    Deboosere, P
    Leinsalu, Mall
    Södertörn University, School of Social Sciences, Sociology. Södertörn University, School of Social Sciences, SCOHOST (Stockholm Centre on Health of Societies in Transition). The National Institute for Health Development, Tallinn, Estonia.
    Lundberg, O
    Martikainen, P
    Strand, BH
    Artnik, B
    Wojtyniak, B
    Mackenbach, JP
    More variation in lifespan in lower educated groups: evidence from 10 European countries2011In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 40, no 6, p. 1703-1714Article in journal (Refereed)
  • 318. van Raalte, Alyson A.
    et al.
    Kunst, Anton E.
    Lundberg, Olle
    Leinsalu, Mall
    Södertörn University, School of Social Sciences, Sociology. Södertörn University, School of Social Sciences, SCOHOST (Stockholm Centre on Health of Societies in Transition).
    Martikainen, Pekka
    Artnik, Barbara
    Deboosere, Patrick
    Stirbu, Irina
    Wojtyniak, Bogdan
    Mackenbach, Johan P.
    The contribution of educational inequalities to lifespan variation2012In: Population Health Metrics, ISSN 1478-7954, E-ISSN 1478-7954, Vol. 10, article id 3Article in journal (Refereed)
    Abstract [en]

    Background: Studies of socioeconomic inequalities in mortality consistently point to higher death rates in lower socioeconomic groups. Yet how these between-group differences relate to the total variation in mortality risk between individuals is unknown. Methods: We used data assembled and harmonized as part of the Eurothine project, which includes census-based mortality data from 11 European countries. We matched this to national data from the Human Mortality Database and constructed life tables by gender and educational level. We measured variation in age at death using Theil's entropy index, and decomposed this measure into its between-and within-group components. Results: The least-educated groups lived between three and 15 years fewer than the highest-educated groups, the latter having a more similar age at death in all countries. Differences between educational groups contributed between 0.6% and 2.7% to total variation in age at death between individuals in Western European countries and between 1.2% and 10.9% in Central and Eastern European countries. Variation in age at death is larger and differs more between countries among the least-educated groups. Conclusions: At the individual level, many known and unknown factors are causing enormous variation in age at death, socioeconomic position being only one of them. Reducing variations in age at death among less-educated people by providing protection to the vulnerable may help to reduce inequalities in mortality between socioeconomic groups.

  • 319. Vasudevan, Subhash G
    et al.
    Johansson, Magnus
    Brooks, Andrew J
    Llewellyn, Lyndon E
    Jans, David A
    Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets.2001In: Il Farmaco, ISSN 0014-827X, E-ISSN 1879-0569, Vol. 56, no 1-2, p. 33-36Article in journal (Refereed)
    Abstract [en]

    Our research is directed towards enhancing the understanding of the molecular biology of dengue virus replication with the ultimate goal being to develop novel antiviral strategies based on preventing critical inter- or intra-molecular interactions required for the normal virus life cycle. The viral RNA-dependent RNA polymerase (NS5) and the viral helicase (NS3) interaction offers a possible target for inhibitors to bind and prevent replication. In this study the yeast-two hybrid system was used to show that a small region of NS5 interacts with NS3, and also with the cellular nuclear transport receptor importin-beta. Furthermore, intramolecular interaction between the two putative domains of NS5 can also be detected by the yeast two-hybrid assay. We have also modified the colony lift assay for the beta-galactosidase reporter activity in intact yeast cells which reflects the strength of interaction between two proteins to a microtiter plate format. This assay offers a unique opportunity to screen for small molecule compounds that block physiologically important interactions.

  • 320.
    Victor Tillberg, Lotta
    Kungliga Tekniska högskolan.
    Konsten att vårda: och ge omsorg2007Doctoral thesis, monograph (Other academic)
  • 321.
    Vikdahl, Linda
    et al.
    Röda Korsets Högskola.
    Gunnarsson, David
    Röda Korsets Högskola.
    Larsen, Joacim
    Röda Korsets Högskola.
    Ståhle, Göran
    Röda Korsets Högskola.
    Saboonchi, Fredrik
    Röda Korsets Högskola.
    Mångfald och hälsa: En kartläggning av vilka kunskapsbehov som finns hos några samhällsaktörer i Södertörnregionen gällande mångfald och hälsa, med fokus på nyanländas etablering.2018Report (Other academic)
  • 322. Vågerö, Denny
    Commentary: The role of alcohol in mortality differences between European countries2007In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 36, no 2, p. 468-469Article in journal (Refereed)
  • 323.
    Vågerö, Denny
    Södertörn University College, School of Social Sciences, SCOHOST (Stockholm Centre on Health of Societies in Transition).
    Do health inequalities persist in the new global order?: A European perspective2006In: Inequalities of the world: [new theoretical frameworks, multiple empirical approaches] / [ed] Göran Therborn, London: Verso Publications , 2006, p. 61-92Chapter in book (Other academic)
  • 324. Vågerö, Denny
    Health inequalities in women and men: Studies of specific causes of death should use household criteria2000In: BMJ. British Medical Journal, E-ISSN 1756-1833, Vol. 320, p. 1286-1287Article in journal (Refereed)
  • 325. Vågerö, Denny
    Material and cultural factors2004In: Key concepts in medical sociology / [ed] Jonathan Gabe, Michael Bury and Mary Ann Elston, London: Sage Publications , 2004, p. 32-35Chapter in book (Other academic)
  • 326.
    Vågerö, Denny
    Stockholm University.
    Where does new theory come from?2006In: Journal of Epidemiology and Community Health, ISSN 0143-005X, E-ISSN 1470-2738, Vol. 60, p. 573-574Article in journal (Refereed)
  • 327.
    Vågerö, Denny
    et al.
    Södertörn University, School of Social Sciences, SCOHOST (Stockholm Centre on Health of Societies in Transition).
    Kislitsyna, Olga
    Self-reported heart symptoms are strongly linked to past and present poverty in Russia: evidence from the 1998 Taganrog interview survey2005In: European Journal of Public Health, ISSN 1101-1262, E-ISSN 1464-360X, Vol. 15, p. 418-423Article in journal (Refereed)
    Abstract [en]

    Background: In this Russian-Swedish collaborative study the question of how symptoms of heart disease are linked to poverty in Russia was addressed. Method: A random sample household survey was conducted in Taganrog, southern Russia. It covered questions about living circumstances, poverty and health. Health questions included both symptoms of heart problems, such as chest pain and high blood pressure, psychological problems such as depression and anxiety, as well as health-related behaviours such as alcohol drinking. Answers from 1972 women and men aged 18-70 are analysed here. Results: The poorest fifth of the population were more than twice as likely as others to report heart symptoms. Problems in affording vegetables, meat or fish, clothes and footwear were linked to heart symptoms more closely than other economic indicators, such as car ownership or ownership of consumer durables. Psychological symptoms, sleeping problems and alcohol drinking were all related to self-reported heart symptoms, but explained little of the excess risks attributable to present poverty. Childhood poverty was also linked to present heart symptoms. Conclusion: Life-time accumulated experience of economic hardship contributes to present levels of heart disease symptomology in Russia.

  • 328.
    Vågerö, Denny
    et al.
    Södertörn University, School of Social Sciences, SCOHOST (Stockholm Centre for Health and Social Change). CHESS, Stockholm Universtiy / Karolinska Institutet.
    Koupil, Ilona
    CHESS, Stockholm Universtiy / Karolinska Institutet.
    Parfenova, Nina
    Russian Academy of Medicine Science, St. Petersburg, Russia.
    Sparen, Pär
    Karolinska Institutet.
    Long-term health consequences following the siege of Leningrad2013In: Early life nutrition and adult health and development: lessons from changing dietary patterns, famines and experimental studies / [ed] L.H. Lumey and Alexander Vaiserman, New York: Nova Science Publishers, Inc., 2013, p. 207-225Chapter in book (Other academic)
    Abstract [en]

    We are interested in the long-term health consequences associated with severe starvation and war trauma, and whether certain "age windows" exist when exposure to such events are particularly harmful.The siege of Leningrad (now St. Petersburg) during World War II provided an opportunity to study this. For 872 days, German troops prevented supplies from reaching Leningrad. Simultaneously, there was a food blockade and a steady and merciless bombardment by shells from guns and from the air. The first winter, 1941/42, represents the most severe food shortage, amounting to mass starvation or semi-starvation. Our late colleague, Professor Dimitri Shestov, had suffered the consequences of the Leningrad siege as a boy and believed that it had taken a toll on people beyond its immediate short- and medium-range consequences. He was particularly concerned about its long-term consequences for circulatory disease. A 1973 US-Soviet agreement, the socalled Lipid Research Clinics Collaboration, gave him an opportunity to study this. From 1975 to 1982 men and women living in Leningrad (now St. Petersburg) were randomly sampled and invited to examine their health and cardiovascular functioning. Dimitri Shestov added a simple question to this examination: "Were you in Leningrad during the blockade?" A third of the participants were. They had experienced peak starvation (in January 1942) at ages 1-31 (women) or 6-26 (men).The mortality follow-up began immediately after the first clinical examinations in 1975 and continued for three decades, until the end of 2005. Our analyses show that the siege of Leningrad, particularly when experienced in puberty, has had long-term effects on blood pressure both in men and women.We also found a raised IHD and stroke risk among those men. This was partly mediated via blood pressure but not by any other measured biological, behavioral, or social factors.Girls experiencing the siege around puberty suffered an elevated risk of dying from breast cancer later in life.The fact that the effect of siege exposure is modified by the age at exposure is highly interesting from a scientific point of view. It may suggest that a reprogramming of physiological systems can occur at specific age windows in response to starvation and/or war trauma. The team that worked from 1975-2005 to collect clinical information and death certificates for participants in the study included Svetlana Plavinskaya, born in Leningrad during the siege. Dimitri Shestov and Svetlana Plavinskaya died in 2010 and 2011, respectively. We dedicate this chapter to their memory.

  • 329. Vågerö, Denny
    et al.
    Koupilová, Ilona
    Leon, David A
    Lithell, Ulla-Britt
    Social determinants of birthweight, ponderal index and gestational age in Sweden in the 1920s and the 1980s1999In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 88, p. 445-453Article in journal (Refereed)
    Abstract [en]
    This study compared the effect of social class and marital status on birth outcomes in Sweden, using (i) data on all births at the Akademiska Hospital in Uppsala from 1920 to 1924 with socioeconomic information from records at birth; and (ii) a linkage of the Medical Births Registry for all births in Sweden in November/December 1985 to the 1985 Census. Preterm births (<37 weeks) have become less common during the 20th century. Between 1920–24 and 1985, mean and median birthweight increased, as did mean ponderal index, indicating a shift to the right of the birthweight and ponderal index distributions. In 1920–24, birthweight and ponderal index were associated with the social class of the household and with the marital status of the mother. Babies of single mothers were lighter and thinner, and had a much greater probability of being born preterm. In contrast, in 1985, maternal marital status (and cohabitation status) had a weaker effect on birthweight and ponderal index. The importance of household social class for ponderal index and preterm birth changed similarly, but its importance for birthweight remained. The mediating mechanism may have changed. Mothers from farming households now gave birth to the heaviest babies (nearly 200 g heavier than those of unskilled workers). Adjustment for a number of factors, including smoking, had a limited effect on these social class differences. In conclusion, biological processes during the foetal period are systematically linked to the social circumstances of the mother, but in a different way in the 1920s and in 1985.
  • 330.
    Vågerö, Denny
    et al.
    Södertörn University, School of Social Sciences, SCOHOST (Stockholm Centre on Health of Societies in Transition).
    Leinsalu, Mall
    Södertörn University, School of Sociology and Contemporary History, Sociology. Södertörn University, School of Social Sciences, SCOHOST (Stockholm Centre on Health of Societies in Transition).
    Commentary: Health inequalities and social dynamics in Europe2005In: BMJ. British Medical Journal, E-ISSN 1756-1833, Vol. 331, no 7510, p. 186-187Article in journal (Refereed)
  • 331. Vågerö, Denny
    et al.
    Modin, Bitte
    Prenatal growth, subsequent marital status, and mortality: longitudinal study2002In: BMJ. British Medical Journal, E-ISSN 1756-1833, Vol. 324, p. 398-Article in journal (Refereed)
  • 332. Vågerö, Denny
    et al.
    Modin, Bitte
    The associations between height, cognition and education and their relevance for health studies: [a comment to Magnusson et al. : International Journal of Epidemiology]2006In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 35, p. 663-664Article in journal (Refereed)
  • 333. Vågerö, Denny
    et al.
    Modin, Bitte
    Koupil, Ilona
    Reproductive history and cardiovascular mortality among women: Evidence from the Uppsala Birth Cohort Multigeneration Study [abstract]2005In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 58, no 5, p. 1077-Article in journal (Refereed)
  • 334.
    Vågerö, Denny
    et al.
    Stockholm University.
    Shestov, Dmitri B.
    Galanti, Maria Rosaria
    Sparén, Pär
    Long term mortality after severe starvation during the siege of Leningrad: authors' reply2004In: BMJ. British Medical Journal, E-ISSN 1756-1833, Vol. 328, no 7435, p. 346-347Article in journal (Refereed)
  • 335.
    Weinryb, Noomi
    et al.
    Uppsala universitet.
    Bubela, Tania
    Univ Alberta, Sch Publ Hlth, Edmonton, AB T6G 1C9, Canada..
    Stepping Into and Out of the Void: Funding Dynamics of Human Embryonic Stem Cell Research in California, Sweden, and South Korea2016In: Stem Cell Reviews, ISSN 1550-8943, E-ISSN 1558-6804, Vol. 12, no 1, p. 8-14Article in journal (Refereed)
    Abstract [en]

    Nonprofit organizations and philanthropists stepped into a funding void caused by controversies over public funding of human embryonic stem cell (hESC) research. Based on interviews of 83 representatives of 53 funders, we examine the motivations and accountability structures of public agencies, corporations, fundraising dependent nonprofit organizations and philanthropic organizations that funded hESC research in three jurisdictions: California, Sweden, and South Korea. While non-traditional forms of funding are essential in the early stages of research advancement, they are unreliable for the long timeframes necessary to advance cell therapies. Such funding sources may enter the field based on high expectations, but may exit just as rapidly based on disappointing rates of progress.

  • 336.
    Werme, Karin
    et al.
    Södertörn University, School of Life Sciences. Stockholm University.
    Wigerius, Michael
    Södertörn University, School of Life Sciences. Stockholm University.
    Johansson, Magnus
    Södertörn University, School of Life Sciences.
    Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling.2008In: Cellular Microbiology, ISSN 1462-5814, E-ISSN 1462-5822, Vol. 10, no 3, p. 696-712Article in journal (Refereed)
    Abstract [en]

    Tick-borne encephalitis virus (TBEV) NS5 protein is a multifunctional RNA-dependent RNA polymerase that is indispensable for viral replication. TBEV is considered to be highly neurovirulent and can cause lethal encephalitis. In this study, we demonstrate a novel interaction between TBEV NS5 and the PDZ protein scribble (hScrib) affecting interferon (IFN) type I and II mediated JAK-STAT signalling. The sequence of TBEV NS5 interacting with hScrib was identified using extensive site-directed mutagenesis analysis. Two consecutive mutations in the methyltransferase (MTase) domain of NS5 were found to disrupt binding to hScrib. Colocalization studies with hScrib demonstrated that TBEV NS5 was present at the plasma membrane of mammalian cells. To address the role of viral interference with the IFN response, NS5 proteins were expressed in IFN-stimulated cells. While TBEV NS5 substantially blocked phosphorylation of STAT1, a mutated NS5 protein defective in hScrib binding failed to inhibit JAK-STAT signalling correctly. Furthermore, hScrib knock-down resulted in re-localization of NS5 to intracellular locations and abrogated the impaired STAT1 phosphorylation. These results define the TBEV NS5 protein in concert with hScrib as an antagonist of the IFN response, by demonstrating a correlation between the association and JAK-STAT interference.

  • 337.
    Westberg, Anna
    Södertörn University College, School of Discourse Studies.
    När livets ramar sätts ur spel: En artikelserie om organdonation2007Student thesis
  • 338.
    Widlund, Lina
    Södertörn University College, School of Discourse Studies.
    Kvinnor, idrott och jämställdhet2007Independent thesis Basic level (degree of Bachelor), 10 points / 15 hpStudent thesis
  • 339.
    Wigerius, Michael
    et al.
    Södertörn University, School of Life Sciences, Chemistry. Södertörn University, School of Life Sciences, Molecular biology.
    Melik, Wessam
    Södertörn University, School of Life Sciences, Chemistry. Södertörn University, School of Life Sciences, Molecular biology.
    Elväng, Annelie
    Södertörn University, School of Life Sciences, Molecular biology.
    Johansson, Magnus
    Södertörn University, School of Life Sciences, Chemistry. Södertörn University, School of Life Sciences, International health.
    Rac1 and Scribble are targets for the arrest of neurite outgrowth by TBE virus NS52010In: Molecular and Cellular Neuroscience, ISSN 1044-7431, E-ISSN 1095-9327, Vol. 44, no 3, p. 260-271Article in journal (Refereed)
    Abstract [en]

    Tick-borne encephalitis virus (TBEV) causes extensive CNS disease in humans known as TBE, however, relatively little is known of the molecular mechanisms for its progress. Here, we now show that TBEV produces defects in neuronal development of PC12 cells through a function of the viral NS5 protein. The methyltransferase domain of NS5 is critical and sufficient for restriction of nerve growth factor induced neurite outgrowth. This effect is reversed by expression of NS5 mutants unable to bind Scribble and unexpectedly, in Scribble depleted cells with binding-competent NS5. Furthermore, we also demonstrate that the Rho GTPase Rac1 and the guanine nucleotide-exchange factor, beta PIX are outcompeted by NS5 for binding to Scribble, linking to effects on neurite outgrowth by TBEV. Together, these findings provide the first experimental evidence that Rac1 and beta PIX are indirect targets of NS5 acting through the multifunctional polarity protein Scribble to oppose neuronal differentiation. In conclusion, our results offer a potential mechanism by which TBEV alters neuronal circuitry and opens new avenues for therapeutic interventions.

  • 340.
    Xue-Franzen, Yongtao
    et al.
    Södertörn University, School of Life Sciences, Molecular biology. Karolinska Institutet.
    Johnsson, Anna
    Södertörn University, School of Life Sciences, Molecular biology. Karolinska Intitutet.
    Brodin, David
    Karolinska Institutet.
    Henriksson, Johan
    Södertörn University, School of Life Sciences, Molecular biology. Karolinska Institutet.
    Bürglin, Thomas R.
    Södertörn University, School of Life Sciences, Molecular biology. Karolinska Institutet.
    Wright, Anthony P. H.
    Södertörn University, School of Life Sciences, Molecular biology. Karolinska Institutet.
    Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles2010In: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 11, article id 200Article in journal (Refereed)
    Abstract [en]

    Background: Gcn5 is a transcriptional coactivator with histone cetyltransferase activity that is conserved with regard to structure as ell as its histone substrates throughout the eukaryotes. Gene egulatory networks within cells are thought to be evolutionarily iverged. The use of evolutionarily divergent yeast species, such as S. erevisiae and S. pombe, which can be studied under similar nvironmental conditions, provides an opportunity to examine the nterface between conserved regulatory components and their cellular pplications in different organisms. esults: We show that Gcn5 is important for a common set of stress esponses in evolutionarily diverged yeast species and that the activity f the conserved histone acetyltransferase domain is required. We define group of KCl stress response genes in S. cerevisiae that are pecifically dependent on Gcn5. Gcn5 is localised to many Gcn5-dependent enes including Gcn5 repressed targets such as FLO8. Gcn5 regulates ivergent sets of KCl responsive genes in S. cerevisiae and S. pombe. enome-wide localization studies showed a tendency for redistribution of cn5 during KCl stress adaptation in S. cerevisiae from short genes to he transcribed regions of long genes. An analogous redistribution was ot observed in S. pombe. onclusions: Gcn5 is required for the regulation of divergent sets of Cl stress-response genes in S. cerevisiae and S. pombe even though it s required a common group of stress responses, including the response o KCl. Genes that are physically associated with Gcn5 require its ctivity for their repression or activation during stress adaptation, roviding support for a role of Gcn5 as a corepressor as well as a oactivator. The tendency of Gcn5 to re-localise to the transcribed egions of long genes during KCl stress adaptation suggests that Gcn5 lays a specific role in the expression of long genes under adaptive onditions, perhaps by regulating transcriptional elongation as has been een for Gcn5 in S. pombe. Interestingly an analogous redistribution of cn5 is not seen in S. pombe. The study thus provides important new nsights in relation to why coregulators like Gcn5 are required for the orrect expression of some genes but not others.

  • 341.
    Zaman, Muhammad Haidar
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Improvement in Hepatitis “C” viral infection with advanced antiviral therapy,treatment – a meta-analysis2015Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Hepatitis is the inflammation of liver and there are many reasons of hepatitis. Among these reasons the viral hepatitis due to hepatitis B virus (HBV) and hepatitis C Virus (HCV) are the common hepatic infections and the major causes of liver cancer and liver cirrhosis in the world especially in Asia and Medal east. HBV and HCV infections are having very high mortality ratio in Europe and every year millions of people become infected and die due to HBV or HCV in Europe and Worldwide. That’s why viral hepatitis needs a serious consideration and perfect treatment.

    Objective: Objective of the study was to analyze the role of ribavirin in HCV treatment and to observe the virological response and relapse against it by using statistical meta-analytical techniques.

    Selection criteria and data collection: For this meta-analysis I used the publication databases PubMed, ScienceDirect and Google Scholar to collect all research articles describing treatment and response of HCV and using the antiviral drugs Ledipasvir and Sofosbuvir (control group) in combination with the active agent Ribavirin.

    Method and Methodology: Meta-analysis was performed using the statistical package R and the package metafore.

    Result and conclusion: The result shows that the use of ribavirin with control group (ledipasvir and sofosbuvir) did not show a significant impact on the sustained virological response (SVR) during and after treatment. But addition of ribavirin in control group effectively reduced the rate of relapse after treatment.

  • 342.
    Åhlin, Erik
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Tuberculosis care in Stockholm: An organizational analysis based on staff perception2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In an increasingly more interconnected world, the importance of epidemiology in public and international health is rapidly increasing. Tuberculosis is one of the diseases that contributes to this, as its lengthy incubation time and annual high mortality count makes it one of the toughest bacteria for the medical community to combat. Sweden is today a low-endemic region but still suffers a number of cases each year. The majority of these infections have occurred abroad.

    This qualitative study aims evaluate the Swedish healthcare systems organizational structure in relation to the treating and tracking of tuberculosis. Key personnel from several different units working with diagnosing, treating and tracking of tuberculosis have been interviewed about their perception regarding the organizational structure. The data have been analyzed through H. Mintzbergs theoretical framework regarding organizational structure. The analysis shows that the current system can be described as an Adhocracy. The organization is highly capable of handling adjustment and producing unique and complex outputs in the form of individualized treatment plans and disease tracking efforts. However, the system is highly dependent on internal communication and has great difficulty in up-scaling and expanding. The study shows that the current system would be challenged by a sharp increase in tuberculosis-cases in Stockholm.

  • 343. Öberg, Lisa
    Barnmorskan och läkaren - kompetens och konflikt i svensk förlossningsvård 1870-19201996Doctoral thesis, monograph (Other academic)
  • 344.
    Öberg, Lisa
    Södertörn University, Avdelning 1, Centre for Studies in Practical Knowledge.
    Luktsinnet i arbetet2003In: Öppna doftsinnet!: dokumentation av seminarium om människans doftsinne, januari 2003, Örebro: Örebro universitet , 2003Conference paper (Other academic)
  • 345.
    Öberg, Lisa
    Södertörn University, Institutionen för medier, konst och filosofi, Centre for Studies in Practical Knowledge.
    Näsans kunskap: Om luktsinnet i arbetsliv, vetenskap och konst2004Collection (editor) (Other academic)
    Abstract [sv]

    Lukter och dofter är gåtfulla - mäktiga men undflyende. En doft avklingar snabbt, även om luktämnet finns kvar i luften, men intrycken lever kvar i vårt inre. Luktsinnet hjälper oss att finna mat och dryck och kärlek, men de dofter som leder oss låter sig ogärna fångas i ord.

    Luktsinnet har betraktats som primitivt, djuriskt. Det förekommer sällan i vetenskapliga studier.

    I Näsans kunskap lyfter fem forskare fram luktsinnet från dess undanskymda plats. De kommer från vitt sklida ämnesområden: konst och litteratur, arbetsliv och yrkeskunnande, filosofi och psykologi. Här presenteras också sensoriken, den vetenskap som utforskar just lukt och smak.

  • 346.
    Öberg, Lisa
    Södertörn University, Avdelning 3, History.
    Så sannt mig Gud hjelpe til lif och själ: Om läkareden i Sverige förr och nu2000In: Människan i historien och samtiden: festskrift till Alf W Johansson, Stockholm: Hjalmarson & Högberg , 2000, p. 289-309Chapter in book (Other academic)
  • 347.
    Öberg, Lisa
    Södertörn University, Avdelning 3, History.
    Varför svär inte svenska läkare ed?2001In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 98, no 37, p. 3935-3937Article in journal (Refereed)
  • 348.
    Öberg, Lisa
    Södertörn University, School of Historical and Contemporary Studies, History. Södertörn University, School of Culture and Education, Teacher Education.
    With an eye to the future2013In: 300 years in the service of life: The Swedish association of midwives / [ed] Margareta Rehn, Donald Boström, Stockholm: Svenska barnmorskeförbundet , 2013, 1, p. 61-64Chapter in book (Other (popular science, discussion, etc.))
  • 349.
    Öhrming, Jan
    Södertörn University College, School of Business Studies, Business studies.
    Hälso- och sjukvårdens fragmentering: från lokalt till transnationellt organiserad sjukvård2008 (ed. 1)Book (Other academic)
  • 350.
    Öhrming, Jan
    Södertörn University College, School of Business Studies, Business studies.
    Sjukvårdens fragmentering och entreprenörerna2008In: Perspektiv på förnyelse och entreprenörskap i offentlig verksamhet / [ed] Anders Lundström, Elisabeth Sundin, Örebro: Forum för småföretagarforskning , 2008, Vol. S. 55-71, p. 55-71Chapter in book (Other academic)
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