sh.sePublications
Change search
Refine search result
2345678 201 - 250 of 2303
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • harvard-anglia-ruskin-university
  • apa-old-doi-prefix.csl
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 201.
    Bertrand, Yann
    et al.
    Södertörn University, School of Life Sciences. Muséum National d'Histoire Naturelle, Paris, France / Göteborgs universitet.
    Härlin, Mikael
    Södertörn University, School of Life Sciences.
    Historicism and essentialism in phylogenetic biologyManuscript (preprint) (Other academic)
  • 202.
    Bertrand, Yann
    et al.
    Södertörn University, School of Life Sciences. Muséum National d'Histoire Naturelle, Paris, France / Göteborgs universitet.
    Härlin, Mikael
    Södertörn University, School of Life Sciences.
    Phylogenetic hypotheses, taxonomic sameness and the reference of taxon names2008In: Zoologica Scripta, ISSN 0300-3256, E-ISSN 1463-6409, Vol. 37, no 3, p. 337-347Article in journal (Refereed)
    Abstract [en]

    When scientists use a taxon name like Mammalia, it is important that they talk about the same thing. But, what does it mean to be the same thing in different phylogenetic hypotheses? And, how is taxonomic reference maintained across hypotheses? Here, we discuss the differences between real and hypothetical clades, and how such a distinction relates to the sameness problem. Since hypotheses influence how we perceive things and pursue science, we find it important to have a functioning nomenclatural system for clades as perceived in phylogenetic hypotheses. As a solution to the sameness problem for such clades, we argue that a taxon name does not primarily refer to a single clade that somehow mirror the reality of branches in the tree of life. Instead we suggest that a taxon name refers to a set, or natural kind, of counterfactual and reconstructed clades.

  • 203.
    Bertrand, Yann
    et al.
    Södertörn University, School of Life Sciences. Muséum National d'Histoire Naturelle, Paris, France.
    Härlin, Mikael
    Södertörn University, School of Life Sciences.
    Stability and universality in the application of taxon names in phylogenetic nomenclature2006In: Systematic Biology, ISSN 1063-5157, E-ISSN 1076-836X, Vol. 55, no 5, p. 848-858Article in journal (Refereed)
  • 204.
    Bertrand, Yann J.
    et al.
    Science and Historical Investigations of Evolution Laboratory of Dubá, Dubá, Czech Republic.
    Johansson, Magnus
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Biology. Örebro University.
    Norberg, Peter
    Sahlgrenska University.
    Revisiting Recombination Signal in the Tick-Borne Encephalitis Virus: A Simulation Approach2016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 10, article id e0164435Article in journal (Refereed)
    Abstract [en]

    The hypothesis of wide spread reticulate evolution in Tick-Borne Encephalitis virus (TBEV) has recently gained momentum with several publications describing past recombination events involving various TBEV clades. Despite a large body of work, no consensus has yet emerged on TBEV evolutionary dynamics. Understanding the occurrence and frequency of recombination in TBEV bears significant impact on epidemiology, evolution, and vaccination with live vaccines. In this study, we investigated the possibility of detecting recombination events in TBEV by simulating recombinations at several locations on the virus' phylogenetic tree and for different lengths of recombining fragments. We derived estimations of rates of true and false positive for the detection of past recombination events for seven recombination detection algorithms. Our analytical framework can be applied to any investigation dealing with the difficult task of distinguishing genuine recombination signal from background noise. Our results suggest that the problem of false positives associated with low detection P-values in TBEV, is more insidious than generally acknowledged. We reappraised the recombination signals present in the empirical data, and showed that reliable signals could only be obtained in a few cases when highly genetically divergent strains were involved, whereas false positives were common among genetically similar strains. We thus conclude that recombination among wild-type TBEV strains may occur, which has potential implications for vaccination with live vaccines, but that these events are surprisingly rare.

  • 205.
    Bertrand, Yann
    et al.
    Södertörn University, School of Life Sciences. Muséum National d'Histoire Naturelle, Paris, France.
    Pteijel, F.
    Göteborgs universitet.
    Rouse, G. W.
    Adelaide University, Australia.
    Taxonomic surrogacy in biodiversity assessments, and the meaning of Linnaean ranks2006In: Systematics and Biodiversity, ISSN 1477-2000, E-ISSN 1478-0933, Vol. 4, no 2, p. 149-159Article in journal (Refereed)
    Abstract [en]

    The majority of biodiversity assessments use species as the base unit. Recently, a series of studies have suggested replacing numbers of species with higher ranked taxa (genera, families, etc.); a method known as taxonomic surrogacy that has an important potential to save time and resources in assesments of biological diversity. We examine the relationships between taxa and ranks, and suggest that species/higher taxon exchanges are founded on misconceptions about the properties of Linnaean classification. Rank allocations in current classifications constitute a heterogeneous mixture of various historical and contemporary views. Even if all taxa were monophyletic, those referred to the same rank would simply denote separate clades without further equivalence. We conclude that they are no more comparable than any other, non-nested taxa, such as, for example, the genus Rattus and the phylum Arthropoda, and that taxonomic surrogacy tacks justification. These problems are also illustrated with data of polychaetous annelid worms from a broad-scale study of benthic biodiversity and species distributions in the Irish Sea. A recent consensus phylogeny for polychaetes is used to provide three different family-level classifications of polychaetes. We use families as a surrogate for species, and present Shannon-Wiener diversity indices for the different sites and the three different classifications, showing how the diversity measures rely on subjective rank allocations.

  • 206.
    Bertrand, Yann
    et al.
    Göteborg University.
    Töpel, Mats
    Göteborg University.
    Elväng, Annelie
    Södertörn University, School of Life Sciences, Molecular biology.
    Melik, Wessam
    Södertörn University, School of Life Sciences, Chemistry. Södertörn University, School of Life Sciences, Molecular biology.
    Johansson, Magnus
    Södertörn University, School of Life Sciences, Chemistry. Södertörn University, School of Life Sciences, International health.
    First Dating of a Recombination Event in Mammalian Tick-Borne Flaviviruses2012In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 2, p. e31981-Article in journal (Refereed)
    Abstract [en]

    The mammalian tick-borne flavivirus group (MTBFG) contains viruses associated with important human and animal diseases such as encephalitis and hemorrhagic fever. In contrast to mosquito-borne flaviviruses where recombination events are frequent, the evolutionary dynamic within the MTBFG was believed to be essentially clonal. This assumption was challenged with the recent report of several homologous recombinations within the Tick-borne encephalitis virus (TBEV). We performed a thorough analysis of publicly available genomes in this group and found no compelling evidence for the previously identified recombinations. However, our results show for the first time that demonstrable recombination (i.e., with large statistical support and strong phylogenetic evidences) has occurred in the MTBFG, more specifically within the Louping ill virus lineage. Putative parents, recombinant strains and breakpoints were further tested for statistical significance using phylogenetic methods. We investigated the time of divergence between the recombinant and parental strains in a Bayesian framework. The recombination was estimated to have occurred during a window of 282 to 76 years before the present. By unravelling the temporal setting of the event, we adduce hypotheses about the ecological conditions that could account for the observed recombination.

  • 207.
    Besara, Sheyno
    et al.
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Barbäck, Zanna
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Spelroll "At Heart": Spelrollers inverkan på erfarna spelares problemlösningsförmåga i vardagen2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Games offer a safe and motivational environment that allows and encourages trial and error. A gamer can act in the game without any real consequences in real life. Thereby a gamer is offered the opportunity to develop a broad set of skills. Games have earlier been proven to develop gamer’s problem-solving skills. Roles, as an important part of a game’s structure, contribute to a deepened and more certain development of a diversity of skills – problem solving as one of them. In this paper we examine the relation between roles and gamer’s development of their problem-solving skills in real life – whether it exits and if so, to what extent.

    We’ve found that roles encourage a creative form of problem solving and that gamers develop their problem-solving skills in real life differently depending on which role they play as. Each role posses a unique set of skills, thereby their performance differs depending on the situation. Gamers develop their problem- solving skills to different extents since the roles require different actions to solve problems in the game. 

  • 208.
    Besara, Sheyno
    et al.
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Barbäck, Zanna
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Webbshop för optik: En förstudie: Vikten av användbarhet och aktuella trender inom e-handel2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Trends are part of shaping the market standards and keep challenging the competition to stay on their toes. E-commerce is a fast growing field, a lot due to the rapid evolution of technology. As a result, new trends emerge and form the market once again. Followed by new trends are new possibilities and measures, which lead to higher demands and expectations from the consumers. To manage an e-business successfully it is a prerequisite to stay updated with the current e-commerce trends to be able to keep up with the competitors. To be able to embrace trends and keep up with the competition, a great mean is usability. It is vital to any kind of service to have a good usability, and to maintain it regularly, for it’s chances of survival in the harsh competition. For returning consumers it is important to listen to their expectations, and see to it that the service meet their needs with user-friendly functions. Since the experience of the service is what stays with them. Usability is the backbone of the service, ensuring the user journey to be as smooth as possible, and enhance both the service itself and the consumers’ experience. So it is not sufficient enough to only implement current trends into the service. Without good usability to complement with – neither the trends nor the service will reach their full potential.

    This paper is a pre-study and a result of a degree project, and covers general guidelines for the development of a web shop for optics. The guidelines are based on research on usability and current e-commerce trends. To produce these guidelines, methods such as Brand Experience Workshop, Creative Session and interviews with the target group have been executed.

  • 209. Beskow, Anne
    et al.
    Wright, Anthony P. H.
    Södertörn University, School of Life Sciences.
    Comparative analysis of regulatory transcription factors in Schizosaccharomyces pombe and budding yeasts2006In: Yeast, ISSN 0749-503X, E-ISSN 1097-0061, Vol. 23, no 13, p. 929-935Article in journal (Refereed)
    Abstract [en]

    Regulatory transcription factors (rTFs), which bind specific DNA sequences in the regulatory regions of genes and subsequently activate or repress transcription, play a central role in programming genomic expression. The number of rTFs in a species might therefore reflect its functional complexity. For simple organisms like yeast, a relatively small number of rTFs might be expected that is fairly constant between yeast species. We show that the budding yeast, Saccharomyces cerevisiae, contains 201 rTfs, which is one of the largest rTF numbers found in yeast species for which genome sequences are available. This is a much higher number than the 129 rTFs found in the fission yeast, Schizosaccharomyces pombe, which is currently the yeast with the lowest number of rTFs. Comparative analysis of several different budding yeast species shows that most of the 'extra' rTFs found in S. cerevisiae were probably acquired as a result of a whole genome duplication (WGD) event that occurred in an ancestor of a subset of budding yeast species. However, we also show that budding yeast species that have not been affected by the WGD contain a greater number of rTFs than S. pombe (mean = 145). Thus, two or more mechanisms have led to the 60% increase in rTFs in S. cerevisiae compared to S. pombe. This difference may correlate with a more extensive functional divergence in budding yeasts compared to fission yeasts. The relatively small number of rTFs in S. pombe make this organism an attractive model for global studies of mechanisms that programme gene expression.

  • 210.
    Betzeki, Christina
    et al.
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Media Technology.
    Swedan, Leyla
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Media Technology.
    Persuasive design som medel för miljövänligt agerande: En studie om hur funktioner i miljöfrämjande mobilapplikationer kan motivera användare att agera miljövänligt2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This study aims to investigate how an environmental mobile application can motivate users to act more eco-friendly by using persuasive design principles. In this study, we identify a set of key principles to consider when designing mobile persuasive technology in order to motivate and influence pro-environmental behavior change. We evaluated three existing mobile applications by using PSD design principles. After the evaluation, one mobile application was selected for usertesting, with a total of six participants. The participants received one week to get familiar with the application and its functionalities . Furthermore, the participants received a survey with general questions about their eco-friendly habits. The upcoming phase included the interview we conducted, which contained questions to bring forward the participants opinions about functions and motivation factors that could affect their usage of eco-friendly applications. The result showed that the design principles rewards, personalization, simulation, self-monitoring, normative influence, cooperation, social comparison, competition and reminders had the greatest influence on the users motivation to use the application and act eco-friendly. The reason of importance for the chosen design principles was mainly due to individual, social and practical factors.

  • 211.
    Betzholtz, Per-Eric
    et al.
    University of Kalmar.
    Ehrig, A
    Lindeborg, M
    Dinnétz, Patrik
    University of Kalmar.
    Food plant density, patch isolation and vegetation height determine occurrence in a Swedish metapopulation of the marsh fritillary Euphydryas aurinia (Rottemburg, 1775) (Lepidoptera, Nymphalidae)2007In: Journal of Insect Conservation, ISSN 1366-638X, E-ISSN 1572-9753, Vol. 11, no 4, p. 343-350Article in journal (Refereed)
    Abstract [en]

    The occurrence pattern of the marsh fritillary was studied within a patch network on the Baltic island Oland, Sweden. Presence/absence was established for potentially suitable habitat patches (n = 158) on calcareous moist grassland and analyzed in a multiple logistic regression model where patch area, patch isolation and nine habitat quality variables were included as explanatory variables. Larval food plant density was positively, and patch isolation negatively, correlated to the presence of Euphydryas aurinia. Area did not contribute to the explanation of the occurrence pattern. Significant interactions between larval food plant density times patch isolation, and larval food plant density times vegetation height, show that with low food plant density the butterfly primarily occurs in patches with a vegetation height of 4-10 cm, within a distance of 250 m from nearest occupied patch. In patches with a high food plant density the butterfly occurs in patches where the vegetation height is higher, 4-16 cm, and the distance to nearest occupied patch can be longer, up to 1.4 km. This study supports earlier findings in other regions, suggesting that a network of adjacent patches with a high food plant density and a vegetation height within the preferred threshold, despite their size, is an apparent conservation goal.

  • 212. Bianchi, Thomas S
    et al.
    Engelhaupt, Erika
    Westman, Per
    Andrén, Thomas
    Rolff, Carl
    Elmgren, Ragnar
    Cyanobacterial blooms in the Baltic Sea: Natural or human-induced?2000In: Limnology and Oceanography, ISSN 0024-3590, E-ISSN 1939-5590, Vol. 45, no 3, p. 716-726Article in journal (Refereed)
    Abstract [en]

    Massive summer blooms of nitrogen-fixing cyanobacteria have been documented in the Baltic Sea since the 19th century, but are reported to have increased in frequency, biomass, and duration in recent decades-presumably in response to the well-documented anthropogenic eutrophication of the Baltic. Here, we present an 8,000-yr record of fossil cyanobacterial pigments, diatom microfossil assemblages, and delta(15)N variations in sediment cores from the Baltic proper. This record indicates that nitrogen-living cyanobacterial blooms are nearly as old as the present brackish water phase of the Baltic Sea, starting as far back as ca. 7000 B.P.-soon after the former freshwater Ancylus Lake turned into the brackish Litorina Sea. Demonstration of cyanobacterial blooms in the Baltic prior to the greatly increased anthropogenic nutrient inputs of the 20th century is important for setting realistic goals when trying to reduce the magnitude of present brooms. Our results suggest that the presently predominating nitrogen (N) limitation of phytoplankton in the Baltic Sea proper is not man-induced, but a natural phenomenon, which has endured for some 7,000 yr. These cyanobacterial blooms were possibly initiated by increased availability of phosphorus (P)-from inflow of P-rich seawater and increased P release from sediments-during periods of deep-water anoxia, caused by the establishment of salinity stratification. Efforts to restore the Baltic proper to a more oligotrophic and natural condition should take into account that nitrogen-fixing cyanobacterial blooms are a characteristic, natural feature of this sea.

  • 213.
    Bidla, Gawa
    et al.
    Stockolms universitet.
    Lindgren, Malin
    Södertörn University, School of Life Sciences.
    Theopold, Ulrich
    Stockholms universitet.
    Dushay, Mitchell S.
    Södertörn University, School of Life Sciences.
    Hemolymph coagulation and phenoloxidase in Drosophila larvae2005In: Developmental and Comparative Immunology, ISSN 0145-305X, E-ISSN 1879-0089, Vol. 29, no 8, p. 669-679Article in journal (Refereed)
    Abstract [en]

    Hemolymph coagulation is a first response to wounding in insects. Although studies have been performed in large-bodied insects such as the moth Galleria mellonella, less is known about clotting in Drosophila melanogaster, the insect most useful for genetic and molecular analyses of innate immunity. Here we show the similarities between clots in Drosophila and Galleria by light- and electron microscopy. Phenoloxidase changes the Drosophila clot's physical properties through cross-linking and melanization, but it is not necessary for preliminary soft clot formation. Bacteria associate with the clot, but this alone does not necessarily kill them. The stage is now set for rapid advances in our understanding of insect hemolymph coagulation, its roles in immune defense and wound healing, and for a more comprehensive grasp of the insect immune system in general.

  • 214. Bindler, Richard
    et al.
    Renberg, Ingemar
    Rydberg, Johan
    Andrén, Thomas
    Södertörn University, School of Life Sciences, Geography. Södertörn University, School of Life Sciences, Environmental science.
    Widespread waterborne pollution in central Swedish lakes and the Baltic Sea from pre-industrial mining and metallurgy2009In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 157, p. 2132-2141Article in journal (Refereed)
    Abstract [en]

    Metal pollution is viewed as a modern problem that began in the 19th century and accelerated through the 20th century; however, in many parts of the globe this view is wrong. Here, we studied past waterborne metal pollution in lake sediments from the Bergslagen region in central Sweden, one of many historically important mining regions in Europe. With a focus on lead (including isotopes), we trace mining impacts from a local scale, through a 120-km-long river system draining into Malaren - Sweden’s third largest lake, and finally also the Baltic Sea. Comparison of sediment and peat records shows that pollution from Swedish mining was largely waterborne and that atmospheric deposition was dominated by long-range transport from other regions. Swedish ore lead is detectable from the 10th century, but the greatest impact occurred during the 16th-18th centuries with improvements occurring over recent centuries, i.e., historical pollution > modern industrial pollution.

  • 215.
    Bisenius Sellgren, Kajsa
    Södertörn University College, Lärarutbildningen.
    En studie om elevers val av metoder vid subtraktionsberäkningar2010Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In this qualitative study of students’ methods of calculating subtractions, I have used interviews, subtraction exercises and analysis of teaching material. The purpose of my study was to explore which methods students in grade three uses when calculating subtractions. I also wanted to highlight which strategies the students use and their comprehension of the concept of subtraction. In the study, I also highlight the different pedagogical ideas on which the teaching material is based on and the students’ choice of methods.  The study shows that the students choose to use the methods”deduct” and “kind of number” independently. Further it also shows that the students choose to switch from the method “deduct” to “kind of number” when the numbers in the exercises are further up on the number axis. When asked, the students answered that subtraction means “minus” which they in turn explained as removing something, an explanation confirmed by the Swedish Academy dictionary. The students’ choice of methods and teaching material is based on different fundamental pedagogical view.

     

  • 216.
    Bjerling, Pernilla
    et al.
    Södertörn University, Avdelning Naturvetenskap. Karolinska Institute.
    Ekwall, Karl
    Södertörn University, Avdelning Naturvetenskap. Karolinska Institute.
    Centromere domain organization and histone modifications2002In: Brazilian journal of medical and biological research, ISSN 0100-879X, E-ISSN 1414-431X, Vol. 35, no 5, p. 499-507Article in journal (Refereed)
    Abstract [en]

    Centromere function requires the proper coordination of several subfunctions, such as kinetochore assembly, sister chromatid cohesion, binding of kinetochore microtubules, orientation of sister kinetochores to opposite spindle poles, and their movement towards the spindle poles. Centromere structure appears to be organized in different, separable domains in order to accomplish these functions. Despite the conserved nature of centromere functions, the molecular genetic definition of the DNA sequences that form a centromere in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, in the fruit fly Drosophila melanogaster, and in humans has revealed little conservation at the level of centromere DNA sequences. Also at the protein level few centromere proteins are conserved in all of these four organisms and many are unique to the different organisms. The recent analysis of the centromere structure in the yeast S. pombe by electron microscopy and detailed immunofluorescence microscopy of Drosophila centromeres have brought to light striking similarities at the overall structural level between these centromeres and the human centromere. The structural organization of the centromere is generally multilayered with a heterochromaun domain and a central core/inner plate region, which harbors the outer plate structures of the kinetochore. It is becoming increasingly clear that the key factors for assembly and function of the centromere structure are the specialized histories and modified histones which are present in the centromeric heterochromatin and in the chromatin of the central core. Thus, despite the differences in the DNA sequences and the proteins that define a centromere, there is an overall structural similarity between centromeres in evolutionarily diverse eukaryotes.

  • 217.
    Bjerling, Pernilla
    et al.
    Södertörn University, School of Chemistry, Biology, Geography and Environmental Science. Uppsala University / University of Copenhagen, Denmark .
    Ekwall, Karl
    Södertörn University, School of Chemistry, Biology, Geography and Environmental Science.
    Egel, R
    Thon, G
    A novel type of silencing factor, Clr2, is necessary for transcriptional silencing at various chromosomal locations in the fission yeast Schizosaccharomyces pombe2004In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 32, no 15, p. 4421-4428Article in journal (Refereed)
    Abstract [en]

    The mating-type region of the fission yeast Schizosaccharomyces pombe comprises three loci: mat1, mat2-P and mat3-M. mat1 is expressed and determines the mating type of the cell. mat2-P and mat3-M are two storage cassettes located in a 17 kb heterochromatic region with features identical to those of mammalian heterochromatin. Mutations in the swi6(+), clr1(+), clr2(+), clr3(+), clr4(+) and clr6(+) genes were obtained in screens for factors necessary for silencing the mat2-P-mat3-M region. swi6(+) encodes a chromodomain protein, clr3(+) and clr6(+) histone deacetylases, and clr4(+) a histone methyltransferase. Here, we describe the cloning and characterization of clr2(+). The clr2(+) gene encodes a 62 kDa protein with no obvious sequence homologs. Deletion of clr2(+) not only affects transcriptional repression in the mating-type region, but also centromeric silencing and silencing of a PolII-transcribed gene inserted in the rDNA repeats. Using chromatin immunoprecipitation, we show that Clr2 is necessary for histone hypoacetylation in the mating-type region, suggesting that Clr2 acts upstream of histone deacetylases to promote transcriptional silencing.

  • 218.
    Bjerling, Pernilla
    et al.
    Södertörn University, Avdelning Naturvetenskap. Karolinska Institutet.
    Silverstein, Rebecca A
    Södertörn University, Avdelning Naturvetenskap. Karolinska Institutet.
    Thon, G
    Caudy, A
    Grewal, S
    Ekwall, Karl
    Södertörn University, Avdelning Naturvetenskap. Karolinska Institutet.
    Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity2002In: Molecular and Cellular Biology, ISSN 0270-7306, E-ISSN 1098-5549, Vol. 22, no 7, p. 2170-2181Article in journal (Refereed)
    Abstract [en]

    Histone deacetylases (HDACs) are important for gene regulation and the maintenance of heterochromatin in eukaryotes. Schizosaccharomyces pombe was used as a model system to investigate the functional divergence within this conserved enzyme family. S. pombe has three HDACs encoded by the hda1(+), clr(3+), and clr6(+) genes. Strains mutated in these genes have previously been shown to display strikingly different phenotypes when assayed for viability, chromosome loss, and silencing. Here, conserved differences in the substrate binding pocket identify Clr6 and Hda1 as class I HDACs, while Clr3 belongs in the class II family. Furthermore, these HDACs were shown to have strikingly different subcellular localization patterns. Hda1 was localized to the cytoplasm, while most of Clr3 resided throughout the nucleus. Finally, Clr6 was localized exclusively on the chromosomes in a spotted pattern. Interestingly, Clr3, the only HDAC present in the nucleolus, was required for ribosomal DNA (rDNA) silencing. Clr3 presumably acts directly on heterochromatin, since it colocalized with the centromere, mating-type region, and rDNA as visualized by in situ hybridization. In addition, Clr3 could be cross-linked to mat3 in chromatin immunoprecipitation experiments. Western analysis of bulk histone preparations indicated that Hda1 (class I) had a generally low level of activity in vivo and Clr6 (class 1) had a high level of activity and broad in vivo substrate specificity, whereas Clr3 (class II) displayed its main activity on acetylated lysine 14 of histone H3. Thus, the distinct functions of the S. pombe HDACs are likely explained by their distinct cellular localization and their different in vivo specificities.

  • 219. Bjerselius, Rickard
    et al.
    Lundstedt-Enkel, Katrin
    Olsén, K Håkan
    Mayer, Ian
    Dimberg, K
    Male goldfish reproductive behaviour and physiology are severely affected by exogenous exposure to 17 beta-estradiol2001In: Aquatic Toxicology, ISSN 0166-445X, E-ISSN 1879-1514, Vol. 53, no 2, p. 139-152Article in journal (Refereed)
    Abstract [en]

    Mature male goldfish were exposed to different concentrations of the natural hormone 17 beta -estradiol (El). Two methods of exposure were employed, via ingestion at 0, 1, 10 and 100 ug/g food and via the water at 0, 1 and 10 mug/l. The fish were exposed fur 74-28 days during the spawning period. The males were then paired with an artificially induced, spawning female and their sexual behaviour was observed during a 15 min period. The physiological status of the fish was also examined with respect to GSI. presence of milt and spawning tubercles and the blood plasma concentration of E-2. Despite the relatively short exposure period. exposure to physiological levels of E-2 was shown to severely affect the male goldfish reproductive behaviour and physiology. In conclusion, the results from this study and the ability to interpret the effects on this well-studied species, show that the effects of E-2, and possibly other estrogenic EDCs have severe effects at several vital levels of male goldfish reproduction. The results also suggests that the hormone E-2 can act as an endocrine disrupting chemical (EDC) in the environment.

  • 220. Björck, Jonas
    et al.
    Andrén, Thomas
    Wastegård, Stefan
    Possnert, Göran
    Schoning, Kristian
    An event stratigraphy for the Last Glacial-Holocene transition in eastern middle Sweden: results from investigations of varved clay and terrestrial sequences2002In: Quaternary Science Reviews, ISSN 0277-3791, E-ISSN 1873-457X, Vol. 21, no 12/13, p. 1489-1501Article in journal (Refereed)
    Abstract [en]

    This paper presents an event stratigraphy for the Last Glacial-Holocene transition in eastern middle Sweden. The event stratigraphy for eastern middle Sweden comprises ten events and covers the time-span from ca 12,900 to 10,200 cal yr BP. The local event stratigraphy has been linked to the GRIP isotopic event stratigraphy by different correlations. The onset of the Younger Dryas is dated to 12,650 cal yr BP. This cold event lasted for ca 1125 cal yr in the area. The Vedde Ash (ca 12,000 cal yr BP) has been recorded in two terrestrial sequences, which makes it possible to exactly link the event stratigraphy to the GRIP ice-core and to marine cores in the North Atlantic region. The final drainage of the Baltic Ice Lake has been dated to ca 11,560 cal yr BP, which predates the Younger Dryas/Preboreal climatic boundary with ca 35 yr. An early Holocene cold event has been detected both in terrestrial and varved clay sequences at ca 11,305-11,185 cal yr BP. This cold event coincides almost exactly with a brackish water phase in the Baltic Sea. A previously unrecorded early Holocene tephra horizon has been found in lacustrine sediments at ca 10,200 cal yr BP.

  • 221. Björck, S.
    et al.
    Andrén, Thomas
    Södertörn University College, School of Life Sciences.
    Jensen, J. B.
    An attempt to resolve the partly conflicting data and ideas on the Ancylus - Littorina transition2008In: Proceedings of the workshop "Relative sea level changes - from subsiding to uplifting coasts" / [ed] Szymon Uścinowicz, Joanna Zachowicz, 2008, p. 21-26Conference paper (Other academic)
  • 222.
    Björk, Malin
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Synthesis of sulfur and seleniumn heterocycles, including derivatives of imidazopyridine and benzimidazole2005Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The chemistry developed in this thesis can be divided into two parts. The first part, which is the major part of the thesis, contains syntheses towards analogues to mutagenic heterocyclic amines found in e.g. meat fried at high temperatures. The second part concentrates on the palladium-(0)catalyzed cross-coupling reactions of 4- and 5-substituted 2,1,3-benzoselenadiazoles. The heterocyclic amines described can be divided into the linear and the angular compounds. Five linear imidazo[4,5-b]pyridines were synthesised via the Friedländer reaction: 2-amino-1 - methylbenzothieno[2,3-e]imidazo[4,5-b]pyridine, 2-amino-1-methy-benzothieno [3,2-e] imidazo[4,5-b] pyridine, 2-amino-1-methylthieno[2,3-elimidazo[4,5-b]-pyridine, 2-amino-1methylthieno[3,2-e]imidazo[4,5-b]pyridine and the sulfur analogue to the cooked-food mutagen IFP, 2-amino- 1,6-dimethylthieno[2,3-e]imidazo[4,5-b]pyridine. Attempts were made to form three thienoimidazo[4,5-b]pyridines via stepwise condensation. The first condensation between creatinine and 2-nitro-3-thiophene-carbaldehyde, 3-amino-2thiophenecarbaldehyde and 4-azido3-thiophenecarbaldehyde yielded thenylidenomethyleneimidazolinones, but only one of these gave the ring closed compound 2-amino-1-methylthieno[2,3-e]imidazo[4,5-b]pyridine by a second condensation. In addition, 2-amino- 1 methyl benzoth ieno[3,2-e] imidazo[4,5 -b] pyridine was transformed into the 2-nitro- and 2-hydroxy derivative. The last linear isomer 2-amino-1methylimidazo[4,5-b]benzothiophene, was synthesized by a different route. The series of angular compounds are considered analogues to the food-mutagen IQx. A series of six homologues of 7-amino-imidazo[4,5-e]-2,1,3-benzoselenadiazoles. Four ring systems were obtained by treating 4-methylamino-3-nitro-phenylenedianmine with a range of biselectrophiles, namely: 2-amino-1-methylbenzo-thiadiazole, -triazole, -diazepinone and 2amino1 -methylimidazobenzimidazole. Among the palladium-(0)-catalyzed cros s- couplings, the Suzuki, Stille, Fleck and Sonogashira reactions were used. These were applied to 4-, or 5-bromo-2,1,3-benzoselenadiazoles. In addition, the 4- and 5-trimethyltin-2,1,3-benzoselenadiazole were synthesized.

  • 223.
    Björk, Malin
    et al.
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Grivas, Spiros
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Classical conditions of Suzuki, Stille, Heck and Sonogashira couplings applied on 4- and 5-substituted 2,1,3-benzoselenadiazolesManuscript (preprint) (Other academic)
  • 224.
    Björk, Malin
    et al.
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Grivas, Spiros
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Synthesis of imidazo[4,5-e]-2,1,3-benzoselenadiazoles and derivatives thereofManuscript (preprint) (Other academic)
  • 225.
    Björk, Malin
    et al.
    Södertörn University, School of Life Sciences. Karolinska Institute.
    Grivas, Spiros
    Södertörn University, School of Life Sciences. Karolinska Institute.
    Synthesis of novel 2-aminoimidazo[4,5-b]pyridines, including the thieno analogue of the cooked-food mutagen IFP2006In: Journal of Heterocyclic Chemistry, ISSN 0022-152X, E-ISSN 1943-5193, Vol. 43, no 1, p. 101-109Article in journal (Refereed)
    Abstract [en]

    Eight new compounds, including three new ring systems obtained via the Friedlander condensation of ortho-aminothiophenecarbaldehydes 11, 21 and 24 with creatinine (8), are reported. The condensation afforded 1, which is the thieno analogue of the cooked-food mutagen IFP (2-amino-1,6-dimethylfuro[2,3-e]imidazo[4,5-b]pyridine), and the benzothieno[2,3-e]- and benzothieno[3,2-e]imidazo[4,5-b]pyridines 2 and 3. Attempts to condense 11 with isocreatinine (12) were unsuccessful. Desulfurization of 3 gave the known cooked-food carcinogen PhIP. The 2-nitro (4) and 2-hydroxy (5) derivatives of 3 are reported. The related 2-amino-1-methyl-imidazo[4,5-b]benzothiophene (25) was synthesized by a different route. Fully assigned H-1 and C-13 nmr data of all new compounds are reported.

  • 226.
    Björk, Malin
    et al.
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Grivas, Spiros
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Synthesis of thienoimidazo[4,5-b]pyridines and thenylidenoimidazolinones2005In: Heterocycles, ISSN 0385-5414, E-ISSN 1881-0942, Vol. 65, no 10, p. 2369-2380Article in journal (Refereed)
    Abstract [en]

    The two isomers 2-amino-1-methylimidazo[4,5-b]thieno[3,2-e]pyridine (3) and 2-amino-1-methylimidazo[4,5-b]thieno[2,3-e]pyridine (4) were synthesized by the Friedlander reaction starting from creatinine and the appropriate aminothiophenecarbaldehydes (11 and 13). Creatinine was also condensed with 2-nitro-3-thiophenecarbaldehyde (10) in ethylene glycol to yield the 2-amino-1-methyl-5-[2-(2-nitro-3-thenylidene)]-2-imidazolin-4-one (7a), with 3-amino-2-thiophenecarbaldehyde (13) under Perkin conditions to yield 2-acetamido-5-[2-(3-acetamido-2-thenylidene)]-1-methyl-2-imidazolin-4-on e (8), and with 4-azido-3-thiophenecarbaldehyde (17) in acetic acid to yield 2-amino-5[2-(4-azido-3-thenylidene)]-1-methyl-2-imidazolin-4-one (9). The thenylidenoimidazolinonc (8) was converted into compound (4).

  • 227.
    Björk, Melanie
    et al.
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Loukkareva, Marsella
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    The Good Tourist: En kvalitativ studie om svenska resenärers perspektiv på hållbar turism i sitt resande med all-inclusive konceptet2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The tourism sector is one of the world's most comprehensive sectors, and it’s developing rapidly, assuming that international travel will increase significantly in the future. The fact that the tourism sector is growing and developing at such a rapid pace also means that the effects both positive and negative increase and will continue to increase. For a continued increase in tourism, a long-term, sustainable plan and development is required. Today, the concept of sustainable tourism is a well-used concept that involves three dimensions, the environmental dimension that protects and preserves the environment. The economic, to maintain a long time economic vitality and the social dimension that adress social justice. The term sustainable tourism is in line with the concept of sustainability that implies development for the future. Today there is many types of travel concept, one of them is all-inclusive which is a popular concept that is growing. The concept it is also criticized for that it does not promote sustainable tourism and development. This study examines Swedish travelers' views on sustainability on the all-inclusive concept. Based on a theoretical framework on the importance of sustainable tourism as well as research on the behavior of the tourist and by means of an empirical survey, the study can demonstrate whether there is awareness of the travelers about sustainability. The study shows empirical evidence that Swedish travelers are aware of sustainability and sustainable tourism, but they do not always act consciousness.

  • 228.
    Björk, Mikael
    et al.
    Stockholms universitet.
    Gilek, Michael
    Stockholms universitet.
    Efficiencies of polychlorinated biphenyl assimilation from water and algal food by the blue mussel (Mytilus edulis)1999In: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 18, no 4, p. 765-771Article in journal (Refereed)
    Abstract [en]

    A novel method was used to estimate assimilation efficiencies (AEs) of dissolved and food associated PCBs (IUPAC 31, 49, and 153) by the Baltic Sea blue mussel (Mytilus edulis). Mussels were exposed to radiolabeled PCBs in a series of shortterm toxicokinetic experiments at different algal food concentrations, both at apparent steady-state (ASS) and non-steady-state (NSS) conditions in respect to PCB partitioning between water and algae. The PCB AEs were calculated using a physiologically based bioaccumulation model where experimentally determined uptake and exposure rates at ASS and NSS conditions were combined into linear equation systems, which were solved for PCB AE from water and food. A positive relationship between PCB uptake and algae clearance by the mussels was observed for all three PCBs. The PCB AEs from both water and food increased with congener hydrophobicity (octanol/water partition coefficient [K-ow]), but AEs decreased with increases in water pumping and filtration rate of the mussels, respectively. The average contribution of food-associated PCB to the total uptake also increased with K-ow from approximately 30% for PCB 31 and PCB 49 to 50% for PCB 153, mainly as a consequence of increased sorption to the algal food.

  • 229.
    Björk, Mikael
    et al.
    Södertörn University College, School of Chemistry, Biology, Geography and Environmental Science.
    Gilek, Michael
    Södertörn University College, School of Chemistry, Biology, Geography and Environmental Science.
    Overview of Ecological RiskCharacterisation Methodologies: ERICA deliverable 4b2005Report (Other academic)
  • 230. Björk, Mikael
    et al.
    Gilek, Michael
    Stockholms universitet.
    Kautsky, Nils
    Näf, Carin
    In situ determination of PCB biodeposition by Mytilus edulis in a Baltic coastal ecosystem2000In: Marine Ecology Progress Series, ISSN 0171-8630, E-ISSN 1616-1599, Vol. 194, p. 193-201Article in journal (Refereed)
    Abstract [en]

    Biodeposits of the blue mussel Mytilus edulis and pelagic and near-bed settling particulate matter were collected in situ over a 1 yr period in a coastal area of the Northern Baltic proper. The amounts of carbon and PCBs (polychlorinated biphenyls) in the collected biodeposits were compared to those in pelagic and near-bed settling material and rates of carbon and PCB biodeposition by mussels were estimated. The filter-feeding activity and subsequent release of faecal matter by the mussels increased gross sedimentation of carbon to benthos by 45 % if compared to areas with no mussels. By selectively feeding on particles rich in organic carbon the mussels also concentrated associated contaminants and thereby increased gross sedimentation of PCBs by 50 %. This suggests that mussel biodeposition will enhance the availability of PCBs to benthic deposit feeders living in or in the vicinity of mussel beds. Extrapolation of the experimental results to the total Swedish coastal zone of the Baltic proper indicates that mussel biodeposition is responsible for a significant part of PCB net sedimentation, i.e. 17 % or 96 kg yr(-1). Consequently, even when seen from a large geographical scale, mussels are important modifiers of PCB cycling by directing considerable amounts of PCBs towards the benthic food web and thereby influencing the retention time of these and probably many other contaminants in the coastal zone. It is also Likely that changes in mussel biomass, for example owing to shifts in primary production or salinity, will markedly affect the transport and fate of contaminants in the Baltic Sea.

  • 231.
    Björk, Petra
    et al.
    Stockholm University.
    Baurén, Göran
    Stockholm University.
    Jin, ShaoBo
    Stockholm University.
    Tong, Yong-Guang
    Karolinska Institutet.
    Bürglin, Thomas R.
    Karolinska Institutet.
    Hellman, Ulf
    Ludwig Institute for Cancer Research.
    Wieslander, Lars
    Stockholm University.
    A novel conserved RNA-binding domain protein, RBD-1, is essential for ribosome biogenesis2002In: Molecular Biology of the Cell, ISSN 1059-1524, E-ISSN 1939-4586, Vol. 13, no 10, p. 3683-3695Article in journal (Refereed)
    Abstract [en]

    Synthesis of the ribosomal subunits from pre-rRNA requires a large number of trans-acting proteins and small nucleolar ribonucleoprotein particles to execute base modifications, RNA cleavages, and structural rearrangements. We have characterized a novel protein, RNA-binding domain-1 (RBD-1), that is involved in ribosome biogenesis. This protein contains six consensus RNA-binding domains and is conserved as to sequence, domain organization, and cellular location from yeast to human. RBD-1 is essential in Caenorhabditis elegans. In the dipteran Chironomus tentans, RBD-1 (Ct-RBD-1) binds pre-rRNA in vitro and anti-Ct-RBD-1 antibodies repress pre-rRNA processing in vivo. Ct-RBD-1 is mainly located in the nucleolus in an RNA polymerase I transcription-dependent manner, but it is also present in discrete foci in the interchromatin and in the cytoplasm. In cytoplasmic extracts, 20-30% of Ct-RBD-1 is associated with ribosomes and, preferentially, with the 40S ribosomal subunit. Our data suggest that RBD-1 plays a role in structurally coordinating pre-rRNA during ribosome biogenesis and that this function is conserved in all eukaryotes.

  • 232.
    Björklund, Isabelle
    et al.
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Wang, Anny
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Re-design av StretchFlex UF: Skapandet av en stärkande visuell profil åt StretchFlex UF2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This paper presents the creation of a strengthening visual profile for StretchFlex UF. The project consists of an external as well as an internal part. The external part is on the order of the company StretchFlex. The company is created under the education concept by the name of Ung Företagsverksamhet (Young Entrepreneurship) and has passed on to the Swedish Championships in Young Entrepreneurship at the Stockholm International Fairs. Of that we have been commissioned to develop an updated logotype for the company, for the current does not keep proper quality according to the client. In excess of this, we also produced a folder that followed the company's visual profile. The internal part of the project is a enlargement of the degree project in which a re-design of StretchFlex's visual profile is done. It comprises the logotype, font, and color scheme, which then has been applied on a variety of different objects such as folders, posters, flyer, documents, envelopes, business cards and brand tags. These components are presented in the form of mock-ups. Deeper studies such as interview, persona and design method has been made with intent to reach the result that is presented at the end of the paper. These methods have been used to get a better understanding on how the visual profile can be strengthened.

  • 233.
    Björkman, Daniel
    Södertörn University College, School of Communication, Technology and Design.
    Datorprogram i skolmiljö: en utvald grundskola som fallstudie2005Independent thesis Basic level (degree of Bachelor)Student thesis
    Abstract [en]

    In this thesis I'm trying to investigate how good educational computer programs work in elementary school. I delimited the study to contain one elementary school in the stages of 6 to 9. The method I used was qualitative and the approach was inductive. I interviewed four teachers and five pupils as the way to collect data for the study. The theories I used were parts from different books with authors, which have done similar studies and researches. I also used the elementary school course documentations as theories.

    From this study I can tell that the selected school's programs are best suited for background information. The programs are not as good for deeper knowledge. The motivation gets better among pupils when using the programs. The programs for mathematic follow their course documentation better than the programs for the social-oriented subjects do. The interviewed teachers and pupils want more programs, and the ability to use the programs fully (which aren?t possibly today due to some circumstances). This study may be continued in the future to include other schools in Sweden.

  • 234.
    Björkman, Johanna
    et al.
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Kardebo, Julia
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Persson, Torill
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
    Att studera varumärken utifrån profil,image och identitet: En komparativ fallstudie av Tallink Silja AB och Viking Line AB2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    If a company is to differentiate itself on a competitive market, a unique concept is required. This helps the consumers regard the company’s products or services as reliable and satisfying. Brands are becoming increasingly important for the costumers engaged in the buying process. This is probably a reaction to the fact that a consumer act emotionally, rather than solely rationally, in a way to fulfil one self. The strength and value of a brand can be measured multiple ways. The main focus of this paper has been to examine two well-known brands in the Baltic cruise industry using the theoretical concepts of corporate profile, corporate image and corporate identity. If these concepts come together, the company brand can be regarded as strong and functional.

     

    The work in this essay was limited to investigating two cruising companies operating in and from Stockholm, Sweden; Tallink Silja AB and Viking Line AB. The paper aimed to explore the constituents of the brands, first separately and then compared to one another, in order to recognise similarities and differences between the two companies. We have furthermore studied customer loyalty as a way to reach a conclusion about the subject itself. The cruising industry is a growing sector of the tourism industry and therefore we found the subject both current and interesting to investigate. The investigation has been divided into several phases and different methods have been applied, since surveys, interviews and own observations of websites and commercial pictures, have all been a part of the empirical data gathering process. This in addition to the theoretical framework based on scientific articles and books covering the subject.

     

    In the concluding chapter we establish that the companies’ profiles, images’ and identities over all do match, and that the companies therefore both have strong brands. We don’t find this fact remarkable however since both companies have broad profiles. This means that even if the image among the customers is divided, a part of the image will always support the profiles since they are both covering a wide range of factors. The survey also showed that there is no big, apparent difference between the companies and even though the brand doesn’t seem to be of a great importance for the customers when choosing a cruising company, we as writers think this could be an effect of the complexity of the concept brand itself. However, we estimate that the importance of brands will grow bigger in the future since the cruise market is constantly changing and facing new obstacles/opportunities.

  • 235.
    Björnberg, Karin Edvardsson
    et al.
    KTH.
    Karlsson, Mikael
    KTH.
    Gilek, Michael
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Environmental Science.
    Hansson, Sven Ove
    KTH.
    Climate and environmental science denial: A review of the scientific literature published in 1990–20152017In: Journal of Cleaner Production, ISSN 0959-6526, E-ISSN 1879-1786, Vol. 167, p. 229-241Article, review/survey (Refereed)
    Abstract [en]

    Abstract Denial of scientific findings is neither a new nor an unexplored phenomenon. In the area of environmental science and policy though, the research on denial has not been systematically summarized and analyzed. This article reviews 161 scientific articles on environmental and climate science denial published in peer reviewed international journals in the last 25 years and aims to both identify research gaps and enable learning on the phenomenon. Such knowledge is needed for the increasingly important task to provide effective response to science denial, in order to put an end to its influence on environmental policy making. The review, which is based on articles found in the databases Web of Science, Scopus and Philosopher's Index, shows that denial by far is most studied in relation to climate change, with a focus on Anglo-American countries, where this form of denial is most common. Other environmental issues and other geographical areas have received much less scientific attention. While the actors behind climate science denial, their various motives and the characteristics of their operations have been thoroughly described, more comparative research between issues and countries is needed in order to draw reliable conclusions about the factors explaining the peculiarities of denial. This may in turn lay the ground for developing and actually testing the effectiveness and efficiency of strategies to counter environmental science denial. Irrespective of the ambitions of environmental goals, science-based policies are always preferable. The scientific community therefore needs to increase its efforts to dismantle false claims and to disclose the schemes of denialists.

  • 236.
    Björninen, Evelina
    et al.
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Media Technology. Evelina Björninen.
    Chammas, Michael
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Media Technology.
    Marknadsföring i sociala medier bland skärgårdsföretag: En kvalitativ studie kring användning av sociala medier hos skärgårdsföretag inom projektet Archipelago Business Development2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In Sweden and Finland, the tourism industry has grown with an export value that is constantly increasing. However, this is mainly occurring in the big cities. From a decision of the Swedish government and the EU, a development project called Archipelago Business Development has emerged. The project has the task of strengthening digital investment in the archipelago. With consumers' access to social media and Word-of-mouth (WOM), companies should re-examine their marketing strategy. This study aims to investigate how companies in the archipelago social media in their marketing, and what pros and cons the companies experience. This is studied through qualitative interviews with project managers within ABD and companies in the archipelago from Finland and Sweden participating in the project. The results show that there are two general types of companies in the archipelago that use social media for marketing to varying degrees.

  • 237. Blacque, O E
    et al.
    Perens, E A
    Boroevich, K A
    Inglis, P N
    Li, C M
    Warner, A
    Khattra, J
    Holt, R A
    Ou, G S
    Mah, A K
    McKay, S J
    Huang, P
    Swoboda, Peter
    Södertörn University, School of Life Sciences. Karolinska Institute.
    Jones, S J M
    Marra, M A
    Baillie, D L
    Moerman, D G
    Shaham, S
    Leroux, M R
    Functional genomics of the cilium, a sensory organelle2005In: Current Biology, ISSN 0960-9822, E-ISSN 1879-0445, Vol. 15, no 10, p. 935-941Article in journal (Refereed)
    Abstract [en]

    Cilia and flagella play important roles in many physiological processes, including cell and fluid movement, sensory perception, and development [1]. The biogenesis and maintenance of cilia depend on intraflagellar transport (IFT), a motility process that operates bidirectionally along the ciliary axoneme [1, 2]. Disruption in IFT and cilia function causes several human disorders, including polycystic kidneys, retinal dystrophy, neurosensory impairment, and Bardet-Bledl syndrome (BBS) [3-5]. To uncover new ciliary components, including IFT proteins, we compared C. elegans ciliated neuronal and nonciliated cells through serial analysis of gene expression (SAGE) and screened for genes potentially regulated by the cillogenic transcription factor, DAF-19 [6]. Using these complementary approaches, we identified numerous candidate ciliary genes and confirmed the ciliated-cell-specific expression of 14 novel genes. One of these, C27H5.7a, encodes a ciliary protein that undergoes IFT. As with other IFT proteins, its ciliary localization and transport is disrupted by mutations in IFT and bbs genes. Furthermore, we demonstrate that the ciliary structural defect of C. elegans dyf-13(mn396) mutants is caused by a mutation in C27H5.7a. Together, our findings help define a ciliary transcriptome and suggest that DYF-13, an evolutionarily conserved protein, is a novel core IFT component required for cilia function.

  • 238.
    Blom, Eva-Lotta
    et al.
    University of Gothenburg.
    Kvarnemo, Charlotta
    University of Gothenburg.
    Dekhla, Isabelle
    University of Gothenburg.
    Schöld, Sofie
    University of Gothenburg.
    Andersson, Mathias H.
    Swedish Defence Research Agency.
    Svensson, Ola
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Mathematics Teaching. University of Gothenburg.
    Amorim, M Clara P
    ISPA-Instituto Universitário, Lisboa, Portugal / Universidade de Lisboa, Lisboa, Portugal.
    Continuous but not intermittent noise has a negative impact on mating success in a marine fish with paternal care2019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, no 1, article id 5494Article in journal (Refereed)
    Abstract [en]

    Anthropogenic underwater noise is a global pollutant of increasing concern but its impact on reproduction in fish is largely unknown. Hence, a better understanding of its consequences for this important link to fitness is crucial. Working in aquaria, we experimentally tested the impact of broadband noise exposure (added either continuously or intermittently), compared to a control, on the behaviour and reproductive success of the common goby (Pomatoschistus microps), a vocal fish with exclusive paternal care. Compared to the intermittent noise and control treatments, the continuous noise treatment increased latency to female nest inspection and spawning and decreased spawning probability. In contrast, many other female and male pre-spawning behaviours, and female ventilation rate (proxies for stress levels) did not differ among treatments. Therefore, it is likely that female spawning decisions were delayed by a reduced ability to assess male acoustic signals, rather than due to stress per se and that the silent periods in the intermittent noise treatment provided a respite where the females could assess the males. Taken together, we show that noise (of similar frequency range as anthropogenic boat noise) negatively affects reproductive success, particularly under a continuous noise exposure.

  • 239.
    Blomberg, Victoria
    et al.
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Tourism Studies.
    Wolf, Julia
    Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Tourism Studies.
    Värna Vårda Visa!: Bevarandet av kulturarv och dess roll inom upplevelseturismen ur ett producentperspektiv2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Our essay revolves around the local history associations and the actors within it as part of the tourism sector. We have researched the driving-forces that these actors possess, their view on modernization and digitalization within the association. With this paper we also want to highlight that local history associations works as a cradle for our cultural heritage. These actors want the life of past times to go hand-in-hand with the digital lifestyle of modern times, which will contribute with historical knowledge for future generations.Furthermore,we discuss how these driving-forces are an important part of the balance between the conventional view on tourism from a management perspective, and the non-profit association’s psycho-social view. Our purpose is to define how local history works within tourism and how big of a role it has within the associations. We discuss different tools at hand and explore what driving-forces that get the actors to use digitalization in certain projects. The method of our essay is to use a theory as a framework for thestatements and arguments that are introduced in our empirical data. With the support of our theory and the results of the interviews, it is our hope to clarify the meaning of cultural heritage site tourism and how the actors work within it.We have used qualitative interviews to discuss the concept of heritage sites and to explain its meaning in a concrete way. We have met with elderly people and made it possible for them to share their memories from past times while also exploring their role within heritage site tourism. In this essay we described the heritage site through local history associations, where we analyze the underlying driving-forces behind the work of individual actors as they attempt to preserve the history of Sweden. This essay also presents the concept of interactive digital storytelling where technology functions as a tool that simplify development of the tourism product . As a conclusion our results show that the actors agreed upon that our history in terms of local history associations and heritage sites needs to be preserved, so that future generations do not lose the feeling of safety and a sense of belonging that comes from being part of a community in their local home environment. The cultural heritage site can be used as a tool to present knowledge to different generations through the means of digital development, the heritage sites can reach a wider audience in the future by presenting interactive modern day solutions.In our essay, we have also found that cultural heritage sites plays an important role in leisure tourism on many different levels through driving-forces of the individuals that offer their surrounding something memorable that will last for eternity.

  • 240.
    Blomskog, Stig
    Södertörn University, School of Social Sciences, Economics.
    A formal analysis of a conventional job evaluation system2007Report (Other academic)
    Abstract [en]

    In this paper we analyze the use of numerical information in the context of job evaluation. The analysis is based on the job evaluation system Steps to Pay Equity, which is recommended by the European Project on Equal Pay supported by the European commission. The main findings can be summarized as follows. Firstly, in Steps to Pay Equity no method is suggested that can be used in order to construct stronger scales than ordinal scales. This implies that rankings of jobs are based on the addition of ordinal scales, which means that the rankings are very unstable for admissible transformations. Secondly, there is no explicit definition or explanation how the weights should be interpreted, something that hampers an assessment about the reasonability of the assigned weights. Thirdly, the convention to classify jobs on predefined levels can give rise to heavy deformations of relevant differences between jobs, which means that received rankings of jobs are unjustified guidance for impartial pay setting. We suggest a possible remedy by illustrating the use of a specific multi-attribute evaluation model.

  • 241.
    Blomskog, Stig
    Södertörn University College, School of Social Sciences, Economics.
    An analysis of the principle ”Equal Pay for Jobs of Equal Value”2007Report (Other academic)
    Abstract [en]

    In this paper we analyze a number of assumptions and conceptual issues that arise in applications of conventional job evaluations, which are used in order to implement the principle “Equal Pay for Jobs of Equal Value” according to the Equal Pay Acts.

    The main findings of the analysis can be summarized as follows: 1) A lack of a distinction between subjective and objective criteria as well as between descriptive and evaluative criteria, 2) A defective interpretation of independency conditions that are necessary in order to represent evaluation of jobs by weighted sums of scores, 3) An incorrect diagnosis and subsequently incorrect remedies of defects in job evaluation methods, 4) An incorrect interpretation of the meaning of key concepts such as “Jobs of Equal Value”, 5) Unwarranted assumptions about formal features of relations defined by the concept “Jobs of Equal Value”.

  • 242.
    Blomskog, Stig
    Södertörn University College, School of Social Sciences, Economics.
    An Evaluation of Employee Performance Based on Imprecise Value Judgments: Two Experiments2007Report (Other academic)
    Abstract [en]

    In this paper we test the usefulness of imprecise value judgments in evaluating employee performance. The test is based on two experiments which evaluate the performance of college lecturers. The experiments are carried out by applying the PRIME model (Preference Ratios in Multi-attribute Evaluation), a specific multi-attribute value model that supports the use of imprecise value judgments. The test shows that the use of imprecise value judgments, as synthesized by the PRIME model, can remedy a number of defects that are identified in conventional evaluation models in regard to job requirements and employee performance.

  • 243.
    Blomskog, Stig
    Södertörn University College, School of Social Sciences, Economics.
    Analys av ett individuellt lönesystem baserad på mångdimensionell beslutsteori2003Report (Other academic)
  • 244.
    Boalt, Elin
    Södertörn University, School of Life Sciences.
    Ecology and evolution of tolerance in two cruciferous species2008Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Tolerance to herbivory is the ability of plants to maintain fitness in spite of damage. The goal of this thesis is to investigate the genetic variation and expression of tolerance within species, determine whether and in what conditions tolerance has negative side-effects, and how tolerance is affected by different ecological factors. Tolerance is investigated with special focus on the effects of different damage types, competitive regimes, history of herbivory, and polyploidization in plants. Studies are conducted as a literature review and three experiments on two cruciferous species Raphanus raphanistrum and Cardamine pratensis.

    In the tolerance experiments, plants are subjected to artificial damage solely, or in a combination with natural damage. A literature review was conducted in order to investigate the effects of damage method. We found that traits related to tolerance, such as growth and fitness were not as sensitive in regard to damage method as measures of induced chemical traits, or measures of secondary herbivory.

    Genetic variation of tolerance was demonstrated within populations of R. raphanistrum and between subspecies of C. pratensis. In R. raphanistrum, traits involved in floral display and male fitness were positively associated with plant tolerance to herbivore damage. A potential cost of tolerance was demonstrated as a negative correlation between levels of tolerance in high and low competitive regimes. I found no evidence of other proposed costs of tolerance in terms of highly tolerant plants suffering of reduced fitness in the absence of herbivores or trade-offs in terms of a negative association between tolerance to apical and leaf damage, or between tolerance and competitive ability. In C. pratensis, higher ploidy level in plants involved higher levels of tolerance measured as clonal reproduction. Furthermore, populations exposed to higher levels of herbivory had better tolerance than populations exposed to lower levels of herbivory. In this thesis, I demonstrate evidence of different components for the evolution of tolerance in plants: genotypic variation, selective factors in terms of costs and ploidization, and selective agents in terms of changing environment or herbivore pressure.

  • 245.
    Boalt, Elin
    et al.
    Södertörn University, School of Life Sciences, Environmental science. Södertörn University, School of Life Sciences, Biology.
    Arvanitis, Leena
    Lehtilä, Kari
    Södertörn University, School of Life Sciences, Environmental science. Södertörn University, School of Life Sciences, Biology.
    Ehrlén, Johan
    The association among herbivory tolerance, ploidy level, and herbivory pressure in Cardamine pratensis2010In: Evolutionary Ecology, ISSN 0269-7653, E-ISSN 1573-8477, Vol. 24, no 5, p. 1101-1113Article in journal (Refereed)
    Abstract [en]

    We tested whether differences in ploidy level and previous exposure to herbivory can affect plant tolerance to herbivory. We conducted a common garden experiment with 12 populations of two ploidy levels of the perennial herb Cardamine pratensis (five populations of tetraploid ssp. pratensis and seven populations of octoploid ssp. paludosa). Earlier studies have shown that attack rates by the main herbivore, the orange tip butterfly Anthocharis cardamines, are lower in populations of octoploids than in populations of tetraploids, and vary among populations. In the common garden experiment, a combination of natural and artificial damage significantly reduced seed and flower production. We measured tolerance based on four plant-performance metrics: survival, growth, seed production and clonal reproduction. For three of these measurements, tolerance of damage did not differ between ploidy levels. For clonal reproduction, the octoploids had a higher tolerance than the tetraploids, although they experience lower herbivore attack rates in natural populations. Populations from sites with high levels of herbivory had higher tolerance, measured by seed production, than populations with low levels of herbivory. We did not detect any significant costs of tolerance. We conclude that high intensity of herbivory has selected for high tolerance measured by seed production in C. pratensis.

  • 246.
    Boalt, Elin
    et al.
    Södertörn University, School of Life Sciences.
    Lehtilä, Kari
    Södertörn University, School of Life Sciences.
    Tolerance to apical and foliar damage: costs and mechanisms in Raphanus raphanistrum2007In: Oikos, ISSN 0030-1299, E-ISSN 1600-0706, Vol. 116, no 12, p. 2071-2081Article in journal (Refereed)
    Abstract [en]

    To study mechanisms underlying plant tolerance to herbivore damage, we used apical and foliar damage as experimental treatments to study whether there are similar tolerance mechanisms to different types of damage. We also studied whether tolerance to different types of damage are associated, and whether there is a cost involved in plant tolerance to different types of herbivore damage. Our greenhouse experiment involved 480 plants from 30 full-sib families of an annual weed Raphanus raphanistrum, wild radish, which were subjected to control and two different simulated herbivore damage treatments, apex removal and foliar damage of 30% of leaf area. Apical damage significantly decreased seed production, whereas foliar damage had no effect. There was a significant genetic variation for tolerance to foliar, but not apical damage. No costs were observed in terms of negative correlation between tolerance to either damage type and fitness of undamaged plants. Tolerances to apical and foliar damage were not significantly correlated with each other. We observed a larger number of significant associations between tolerance and reproductive traits than between tolerance and vegetative traits. Plant height and leaf size of damaged plants interacted in their association to tolerance to foliar damage. Inflorescence number and pollen quantity per flower of damaged plants were positively associated with tolerance to apical damage. In late-flowering genotypes, petal size of undamaged plants and pollen quantity of damaged plants were positively associated with tolerance to foliar damage. In summary, traits involved in floral display and male fitness were associated with plant tolerance to herbivore damage.

  • 247.
    Bogdan, Cristian
    et al.
    KTH, Människa-datorinteraktion, MDI.
    Ertl, D
    Falb, J
    Green, Anders
    KTH, Människa-datorinteraktion, MDI.
    Kaindl, H
    A Case Study of Remote Interdisciplinary Designing through Video Prototypes2012In: Proceedings of the 45th Annual Hawaii International Conference on System Sciences (HICSS-45), 2012, p. 504-513Conference paper (Refereed)
  • 248.
    Bogdan, Cristian
    et al.
    KTH, Människa-datorinteraktion, MDI.
    Ertl, D.
    Goller, M.
    Green, Anders
    KTH, Människa-datorinteraktion, MDI.
    Severinson Eklundh, Kerstin
    KTH, Människa-datorinteraktion, MDI.
    Towards HRI on the Move with Mixed Initiative2010In: Proceeding of New Frontiers in Human-Robot Interaction Symposium of the Convention Artificial Intelligence and Simulation of Behaviour (AISB) 2010, 2010, p. 22-26Conference paper (Refereed)
  • 249.
    Bogdan, Cristian
    et al.
    KTH, Människa-datorinteraktion, MDI.
    Ertl, Dominik
    Hüttenrauch, Helge
    Södertörn University, School of Communication, Media and it, Media technology. KTH, Människa-datorinteraktion, MDI.
    Göller, Michael
    Green, Anders
    KTH, Människa-datorinteraktion, MDI.
    Severinsson Eklundh, Kerstin
    KTH, Människa-datorinteraktion, MDI.
    Falb, Jürgen
    Kaindl, Hermann
    Evaluation of robot body movements supporting communication: Towards HRI on the move2011In: New Frontiers in Human–Robot Interaction / [ed] Kerstin Dautenhahn, Joe Saunders, Philadelphia: John Benjamins Publishing Company , 2011, p. 185-210Chapter in book (Refereed)
    Abstract [en]

    In designing socially interactive robots we have focused on robot movement and its role in multi-modal human-robot communication. In this chapter we describe design and evaluation of robot body movements supporting communication, investigating the idea of using speed and orientation adjustments as design elements in human-robot interaction. The scenario studied includes a robotic shopping trolley that offers products via speech and GUI to the user while both are moving in a supermarket-like environment. Our results show that if the robot slows down while making such offers, users are more prone to react upon them and to take the product. However, even from our early pre-study with mock-up robots we observed that users tended not to mention the robot’s slow-down movements, even if these movements were shown several times to them during a video-based debriefing. This phenomenon, that users react implicitly on the robot’s movements without being consciously aware of them, was confirmed during an experimental study with a fully integrated robot prototype. We discuss our results by reflecting on human-robot interaction design methods, and we draw implications from the lessons learned in the study of the design of robot behaviours. In particular, we list a whole set of challenges for HRI when both the user and the robot are moving.

  • 250. Bogdan, Cristian
    et al.
    Rossitto, Chiara
    Normark, Maria
    Jorge (Adler), Pedro
    Eklundh, Kerstin Severinson
    On a Mission without a Home Base: Conceptualizing Nomadicity in Student Group Work2006In: Cooperative systems design: seamless integration of artifacts and conversations - enhanced concepts of infrastructure for communication / [ed] Hassanaly P, Herrmann T, Kunau G, Zacklad M, Amsterdam: IOS Press , 2006, p. 23-38Conference paper (Refereed)
    Abstract [en]

    We are observing that the current body of CSCW research is focusing either on stable workplaces with a single cooperative unit or on mobile work, with highly mobile professionals. We are attempting to fill the gap between workplace and mobile with a field study of student work, which we regard as exhibiting a high degree of nomadicity. After comparing student work with centres of coordination and mobility work, we unpack the notion of nomadicity as a work condition, constituted by a complex of discontinuities, leading to work partitioning and re-assembly. We draw design and methodological implications.

2345678 201 - 250 of 2303
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • harvard-anglia-ruskin-university
  • apa-old-doi-prefix.csl
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf