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  • 1. Massinen, Satu
    et al.
    Hokkanen, Marie-Estelle
    Matsson, Hans
    Tammimies, Kristiina
    Tapia-Paez, Isabel
    Dahlstrom-Heuser, Vanina
    Kuja-Panula, Juha
    Burghoorn, Jan
    Södertörn University, School of Life Sciences, Molecular biology.
    Jeppsson, Kristian E.
    Södertörn University, School of Life Sciences, Molecular biology.
    Swoboda, Peter
    Södertörn University, School of Life Sciences, Molecular biology.
    Peyrard-Janvid, Myriam
    Toftgard, Rune
    Castren, Eero
    Kere, Juha
    Increased Expression of the Dyslexia Candidate Gene DCDC2 Affects Length and Signaling of Primary Cilia in Neurons2011In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 6, no 6, p. e20580-Article in journal (Refereed)
    Abstract [en]

    DCDC2 is one of the candidate susceptibility genes for dyslexia. It belongs to the superfamily of doublecortin domain containing proteins that bind to microtubules, and it has been shown to be involved in neuronal migration. We show that the Dcdc2 protein localizes to the primary cilium in primary rat hippocampal neurons and that it can be found within close proximity to the ciliary kinesin-2 subunit Kif3a. Overexpression of DCDC2 increases ciliary length and activates Shh signaling, whereas downregulation of Dcdc2 expression enhances Wnt signaling, consistent with a functional role in ciliary signaling. Moreover, DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia.

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