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  • 1. Archer, Amena
    et al.
    Lauter, Gilbert
    Södertörns högskola, Institutionen för livsvetenskaper.
    Hauptmann, Giselbert
    Södertörns högskola, Institutionen för livsvetenskaper.
    Mode, Agneta
    Gustafsson, Jan-Ake
    Transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish2008Inngår i: Developmental Dynamics, ISSN 1058-8388, E-ISSN 1097-0177, Vol. 237, nr 4, s. 1090-1098Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Mammalian liver-X-receptors (LXRs) are transcription factors activated by oxysterols. They play an essential role in lipid and glucose metabolism. We have cloned the open reading frame of zebrafish lxr and describe its genomic organization. Zebrafish lxr encodes a 50-kDa protein with high sequence similarity to mammalian LXR alpha. In transfection assays, the encoded protein showed transcriptional activity in response to LXR-ligands. Treatment of adult zebrafish with the synthetic LXR ligand, GW3965, induced expression of genes involved in hepatic cholesterol and lipid pathways. Using qPCR and in situ hybridization, we found ubiquitous expression of lxr mRNA during the first 24 hr of development, followed by more restricted expression, particularly to the liver at 3dpf and the liver and intestine at 4dpf. In adult fish, all examined organs expressed lxr. In addition to a metabolic role of lxr, the temporal expression pattern suggests a developmental role in, e.g., the liver and CNS.

  • 2.
    Chandrasekar, Gayathri
    et al.
    Södertörns högskola, Institutionen för livsvetenskaper.
    Lauter, Gilbert
    Södertörns högskola, Institutionen för livsvetenskaper.
    Hauptmann, Giselbert
    Södertörns högskola, Institutionen för livsvetenskaper.
    Distribution of corticotropin-releasing hormone in the developing zebrafish brain2007Inngår i: Journal of Comparative Neurology, ISSN 0021-9967, E-ISSN 1096-9861, Vol. 505, nr 4, s. 337-351Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Corticotropin-releasing hormone (CRH) plays a central role in the physiological regulation of the hypothalamus-pituitary-adrenal/interrenal axis mediating endocrine, behavioral, autonomic, and immune responses to stress. Despite the wealth of knowledge about the physiological roles of CRH, the genetic mechanisms by which CRH neurons arise during development are poorly understood. As a first step toward analyzing the molecular and genetic pathways involved in CRH lineage specification, we describe the developmental distribution of CRH neurons in the embryonic zebrafish, a model organism for functional genomics and developmental biology. We searched available zebrafish expressed sequence tag (EST) databases for CRH-like sequences and identified one EST that contained the complete zebrafish CRH open reading frame (ORF). The CRH precursor sequence contained a signal peptide, the CRH peptide, and a cryptic peptide with a conserved sequence motif. RT-PCR analysis showed crh expression in a wide range of adult tissues as well as during embryonic and larval stages. By whole-mount in situ hybridization histochemistry, discrete crh-expressing cell clusters were found in different parts of the embryonic zebrafish brain, including telencephalon, preoptic region, hypothalamus, posterior tuberculum, thalamus, epiphysis, midbrain tegmentum, and rostral hindbrain and in the neural retina. The localization of crh mRNA within the preoptic region is consistent with the central role of CRH in the teleost stress response through activation of the hypothalamic-pituitary-interrenal axis. The widespread distribution of CRH-synthesizing cells outside the preoptic region suggests additional functions of CRH in the embryonic zebrafish brain.

  • 3. Hao, Limin
    et al.
    Johnsen, Robert
    Lauter, Gilbert
    Södertörns högskola, Institutionen för livsvetenskaper. Karolinska Institute.
    Baillie, David
    Bürglin, Thomas R.
    Södertörns högskola, Institutionen för livsvetenskaper. Karolinska Institute.
    Comprehensive analysis of gene expression patterns of hedgehog-related genes2006Inngår i: BMC Genomics, E-ISSN 1471-2164, Vol. 7, s. 280-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The Caenorhabditis elegans genome encodes ten proteins that share sequence similarity with the Hedgehog signaling molecule through their C-terminal autoprocessing Hint/Hog domain. These proteins contain novel N-terminal domains, and C. elegans encodes dozens of additional proteins containing only these N-terminal domains. These gene families are called warthog, groundhog, ground-like and quahog, collectively called hedgehog (hh)-related genes. Previously, the expression pattern of seventeen genes was examined, which showed that they are primarily expressed in the ectoderm. Results: With the completion of the C. elegans genome sequence in November 2002, we reexamined and identified 61 hh-related ORFs. Further, we identified 49 hh-related ORFs in C. briggsae. ORF analysis revealed that 30% of the genes still had errors in their predictions and we improved these predictions here. We performed a comprehensive expression analysis using GFP fusions of the putative intergenic regulatory sequence with one or two transgenic lines for most genes. The hh-related genes are expressed in one or a few of the following tissues: hypodermis, seam cells, excretory duct and pore cells, vulval epithelial cells, rectal epithelial cells, pharyngeal muscle or marginal cells, arcade cells, support cells of sensory organs, and neuronal cells. Using time-lapse recordings, we discovered that some hh-related genes are expressed in a cyclical fashion in phase with molting during larval development. We also generated several translational GFP fusions, but they did not show any subcellular localization. In addition, we also studied the expression patterns of two genes with similarity to Drosophila frizzled, T23D8.1 and F27E11.3A, and the ortholog of the Drosophila gene dally-like, gpn-1, which is a heparan sulfate proteoglycan. The two frizzled homologs are expressed in a few neurons in the head, and gpn-1 is expressed in the pharynx. Finally, we compare the efficacy of our GFP expression effort with EST, OST and SAGE data. Conclusion: No bona-fide Hh signaling pathway is present in C. elegans. Given that the hh-related gene products have a predicted signal peptide for secretion, it is possible that they constitute components of the extracellular matrix (ECM). They might be associated with the cuticle or be present in soluble form in the body cavity. They might interact with the Patched or the Patched-related proteins in a manner similar to the interaction of Hedgehog with its receptor Patched.

  • 4.
    Lauter, Gilbert
    et al.
    Södertörns högskola, Institutionen för livsvetenskaper. Karolinska Institutet.
    Söll, Iris
    Södertörns högskola, Institutionen för livsvetenskaper. Karolinska Institutet.
    Hauptmann, Giselbert
    Södertörns högskola, Institutionen för livsvetenskaper. Karolinska Institutet.
    PACAP in zebrafish neurodevelopment2009Inngår i: Mechanisms of Development, ISSN 0925-4773, E-ISSN 1872-6356, Vol. 126, s. S235-S235Artikkel i tidsskrift (Fagfellevurdert)
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