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  • 1.
    Lilja, Karl
    et al.
    Södertörn University, School of Life Sciences. Stockholm University.
    Prevodnik, Andreas
    Södertörn University, School of Life Sciences. Stockholm University.
    Gardeström, Johanna
    Stockholm University.
    Elfwing, Tina
    Stockholm University.
    Tedengren, Michael
    Stockholm University.
    Bollner, Tomas
    Södertörn University, School of Life Sciences.
    Regional differences in mRNA responses in blue mussels within the Baltic proper2008In: Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, ISSN 1532-0456, E-ISSN 1878-1659, Vol. 148, no 2, p. 101-106Article in journal (Refereed)
    Abstract [en]

    Mussels (Mytilus sp.) from two regions along the permanent salinity gradient within the Baltic proper were exposed to copper (35 ppb) or petrol (0.3 mL/L) for 10 days and analyzed for mRNA expressions in gill tissue. Expression of mRNAs for the heat shock proteins HSP70 and HSP90 was significantly induced by copper, but not by petrol. For the metallothioneins MT10 and MT20, regional differences in mRNA expressions could be seen. In mussels from the northern Baltic proper, MT20 expression increased 2.8 and 3.4 times, after exposure to copper and petrol, respectively. In contrast, no change could be seen in MT20 expression for mussels from the southern Baltic proper. MT10 showed a peculiar expression not previously described. For some mussels, no expression at all was detected, some showed a weak expression and for some individuals a strong expression could be seen. For the mussels from the southern Baltic proper, the number of individuals with a strong expression of MT10 increased from 1 out of 18 (control), to 7 and 8, after exposure to copper and petrol, respectively. The results clearly show that responses vary between different regions within the Baltic proper, which emphasises the importance to study interactions between contaminants, populations and regions.

  • 2.
    Prevodnik, Andreas
    et al.
    Södertörn University, School of Life Sciences. Stockholm University.
    Gardeström, Johanna
    Stockholm University.
    Lilja, Karl
    Södertörn University, School of Life Sciences. Stockholm University.
    Elfwing, Tina
    Stockholm University.
    McDonagh, Brian
    University College Cork, Ireland.
    Petrovic, Natasa
    Stockholm University.
    Tedengren, Michael
    Stockholm University.
    Sheehan, David
    University College Cork, Ireland.
    Bollner, Tomas
    Södertörn University, School of Life Sciences.
    Oxidative stress in response to xenobiotics in the blue mussel Mytilus edulis L.: evidence for variation along a natural2007In: Aquatic Toxicology, ISSN 0166-445X, E-ISSN 1879-1514, Vol. 82, no 1, p. 63-71Article in journal (Refereed)
    Abstract [en]

    Blue mussels (Mytilus edulis L.) collected at three sampling sites in each of three geographical regions (South, Middle, North) along the permanent longitudinal South-North salinity gradient of the Baltic Sea, were exposed for 10 days to copper (35 ppb) or 95 octane petrol (0.3%0). During the experiment, they were maintained at the respective sampling site salinity. Scope for growth (SFG) was determined, and biochemical stress markers (protein carbonyl groups, disulfide bond formation, and glutathione transferase (GST), and catalase (CAT) activities) were investigated in gill tissue upon termination of the experiment. Treatment and regional effects for SFG and protein carbonyl groups were all significant for petrol. The largest increase in protein carbonyl groups was observed in the North. Mussels from the southern, more saline (similar to 7%) region had the highest SFG, and displayed the largest SFG decrease in response to treatment, indicating that they had the most energy available for allocation to stress response. They also displayed the least increase in the level of protein carbonyl groups. Mussels from the Northern, less saline (similar to 5%) region had the highest degree of protein carbonyl groups in response to both treatments, and lowest average SFG. Silver stained diagonal gels for samples from one sampling site in South and North, respectively, demonstrated differences in disulfide bond profiles for both stress treatments. There was also a regional difference in the number of protein disulfides observed on diagonal gels. The most diverse protein disulfide response was found in South. No treatment related effects on GST and CAT activities were observed. We suggest that both SFG and protein carbonyl groups show that geographical difference in stress susceptibility, previously established between the North and the Baltic Seas, also apply on a regional scale within the Baltic Sea, along the salinity gradient.

  • 3.
    Prevodnik, Andreas
    et al.
    Södertörn University, School of Life Sciences. Stockholm University.
    Lilja, Karl
    Södertörn University, School of Life Sciences. Stockholm University.
    Bollner, Tomas
    Södertörn University, School of Life Sciences.
    Benzo[a]pyrene up-regulates the expression of the proliferating cell nuclear antigen (PCNA) and multixenobiotic resistance polyglycoprotein (P-gp) in Baltic Sea blue mussels (Mytilus edulis L.)2007In: Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, ISSN 1532-0456, E-ISSN 1878-1659, Vol. 145, no 2, p. 265-274Article in journal (Refereed)
    Abstract [en]

    The expression of protein biomarkers in Baltic Sea blue mussels was analyzed after three days exposure to low (2.8 mu g/animal/day), intermediate (28 mu g/animal/day), or high (280 mu g/animal/day) nominal doses of benzo[a]pyrene (BaP). Significant expression changes were found in the animals exposed to the low dose, the lowest reported dose for DNA adduct formation in the gills of Baltic Sea blue mussels. Up-regulated expression of the proliferating cell nuclear antigen (PCNA), quantified from Western blots, and no change in the 5-bromo-deoxyuridine (BrdU) staining pattern, determined by immunocytochemistry, indicated that the observed PCNA response was mainly non-proliferative, and thus possibly due to DNA damage. The expression of the multixenobiotic resistance polyglycoprotein (P-gp) was also up-regulated, proving its usefulness as an exposure marker to planar organic compounds. No effect of the BaP treatment with respect to the retinoblastoma 110 protein or heat shock proteins 60 and 70 was found. The variance in the medium and high dose data was too large to allow for the detection of significant expression changes. We suggest PCNA to be a marker for genotoxic stress derived from the polycyclic aromatic hydrocarbon BaP, irrespective of whether the stress leads to DNA repair or to cell proliferation.

  • 4.
    Prevodnik, Andreas
    et al.
    Södertörn University College, School of Life Sciences.
    Lilja, Karl
    Södertörn University College, School of Life Sciences.
    Bollner, Tomas
    Södertörn University College, School of Life Sciences.
    Effects of copper and cadmium on protein expression in Baltic sea blue mussels (Mytilus edulis sp.)2006In: Marine Environmental Research, ISSN 0141-1136, E-ISSN 1879-0291, Vol. 62, p. S90-S91Article in journal (Refereed)
  • 5.
    Prevodnik, Andreas
    et al.
    Södertörn University, School of Life Sciences. Stockholms universitet.
    Lilja, Karl
    Södertörn University, School of Life Sciences. Stockholms universitet.
    Bollner, Tomas
    Södertörn University, School of Life Sciences.
    Protein biomarker response in Baltic Sea blue mussels (Mytilus edulis L.) exposed to copper or cadmiumManuscript (preprint) (Other academic)
1 - 5 of 5
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