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  • 1. Berger, Juerg
    et al.
    Senti, Kirsten-Andre
    Senti, Gabriele
    Södertörn University, School of Life Sciences. Karolinska Institute.
    Newsome, Timothy P.
    Åsling, Bengt
    Dickson, Barry J.
    Suzuki, Takashi
    Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system2008In: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 4, no 5, p. Online-Article in journal (Refereed)
    Abstract [en]

    Forward genetic screens in model organisms are an attractive means to identify those genes involved in any complex biological process, including neural circuit assembly. Although mutagenesis screens are readily performed to saturation, gene identification rarely is, being limited by the considerable effort generally required for positional cloning. Here, we apply a systematic positional cloning strategy to identify many of the genes required for neuronal wiring in the Drosophila visual system. From a large-scale forward genetic screen selecting for visual system wiring defects with a normal retinal pattern, we recovered 122 mutations in 42 genetic loci. For 6 of these loci, the underlying genetic lesions were previously identified using traditional methods. Using SNP-based mapping approaches, we have now identified 30 additional genes. Neuronal phenotypes have not previously been reported for 20 of these genes, and no mutant phenotype has been previously described for 5 genes. The genes encode a variety of proteins implicated in cellular processes such as gene regulation, cytoskeletal dynamics, axonal transport, and cell signalling. We conducted a comprehensive phenotypic analysis of 35 genes, scoring wiring defects according to 33 criteria. This work demonstrates the feasibility of combining large-scale gene identification with large-scale mutagenesis in Drosophila, and provides a comprehensive overview of the molecular mechanisms that regulate visual system wiring.

  • 2. Li, Chunmei
    et al.
    Inglis, Peter N.
    Leitch, Carmen C.
    Efimenko, Evgeni
    Södertörn University, School of Life Sciences.
    Zaghloul, Norann A.
    Mok, Calvin A.
    Davis, Erica E.
    Bialas, Nathan J.
    Healey, Michael P.
    Heon, Elise
    Zhen, Mei
    Swoboda, Peter
    Södertörn University, School of Life Sciences.
    Katsanis, Nicholas
    Leroux, Michel R.
    An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes2008In: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 4, no 3, p. e1000044-Article in journal (Refereed)
    Abstract [en]

    MIP-T3 is a human protein found previously to associate with microtubules and the kinesin-interacting neuronal protein DISC1 ( Disrupted-in-Schizophrenia 1), but whose cellular function(s) remains unknown. Here we demonstrate that the C. elegans MIP-T3 ortholog DYF-11 is an intraflagellar transport (IFT) protein that plays a critical role in assembling functional kinesin motor-IFT particle complexes. We have cloned a loss of function dyf-11 mutant in which several key components of the IFT machinery, including Kinesin-II, as well as IFT subcomplex A and B proteins, fail to enter ciliary axonemes and/or mislocalize, resulting in compromised ciliary structures and sensory functions, and abnormal lipid accumulation. Analyses in different mutant backgrounds further suggest that DYF-11 functions as a novel component of IFT subcomplex B. Consistent with an evolutionarily conserved cilia-associated role, mammalian MIP-T3 localizes to basal bodies and cilia, and zebrafish mipt3 functions synergistically with the Bardet-Biedl syndrome protein Bbs4 to ensure proper gastrulation, a key cilium- and basal body-dependent developmental process. Our findings therefore implicate MIP-T3 in a previously unknown but critical role in cilium biogenesis and further highlight the emerging role of this organelle in vertebrate development.

  • 3. Strålfors, Annelie
    et al.
    Walfridsson, Julian
    Södertörn University, School of Life Sciences, Molecular biology.
    Bhuiyan, Hasanuzzaman
    Södertörn University, School of Life Sciences, Molecular biology.
    Ekwall, Karl
    Södertörn University, School of Life Sciences, Molecular biology.
    The FUN30 Chromatin Remodeler, Fft3, Protects Centromeric and Subtelomeric Domains from Euchromatin Formation2011In: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 7, no 3, article id e1001334Article in journal (Refereed)
    Abstract [en]

    The chromosomes of eukaryotes are organized into structurally and functionally discrete domains. This implies the presence of insulator elements that separate adjacent domains, allowing them to maintain different chromatin structures. We show that the Fun30 chromatin remodeler, Fft3, is essential for maintaining a proper chromatin structure at centromeres and subtelomeres. Fft3 is localized to insulator elements and inhibits euchromatin assembly in silent chromatin domains. In its absence, euchromatic histone modifications and histone variants invade centromeres and subtelomeres, causing a mis-regulation of gene expression and severe chromosome segregation defects. Our data strongly suggest that Fft3 controls the identity of chromatin domains by protecting these regions from euchromatin assembly.

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