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Stress Sensitivity and Psychotic Experiences in 39 Low- and Middle-Income Countries
University of Maryland, Baltimore, USA.
Universitat de Barcelona, Barcelona, Spain / CIBERSAM, Madrid, Spain.
University of Maryland, Baltimore, USA.
University of California Berkeley, Berkeley, USA / Prevention Research Center, Oakland, USA.
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2016 (English)In: Schizophrenia Bulletin, ISSN 0586-7614, E-ISSN 1745-1701, Vol. 42, no 6, 1353-1362 p.Article in journal (Refereed) Published
Abstract [en]

Stress has a central role in most theories of psychosis etiology, but the relation between stress and psychosis has rarely been examined in large population-level data sets, particularly in low- and middle-income countries. We used data from 39 countries in the World Health Survey (n = 176 934) to test the hypothesis that stress sensitivity would be associated with psychotic experiences, using logistic regression analyses. Respondents in low-income countries reported higher stress sensitivity (P < .001) and prevalence of psychotic experiences (P < .001), compared to individuals in middle-income countries. Greater stress sensitivity was associated with increased odds for psychotic experiences, even when adjusted for co-occurring anxiety and depressive symptoms: adjusted odds ratio (95% CI) = 1.17 (1.15-1.19) per unit increase in stress sensitivity (range 2-10). This association was consistent and significant across nearly every country studied, and translated into a difference in psychotic experience prevalence ranging from 6.4% among those with the lowest levels of stress sensitivity up to 22.2% among those with the highest levels. These findings highlight the generalizability of the association between psychosis and stress sensitivity in the largest and most globally representative community-level sample to date, and support the targeting of stress sensitivity as a potential component of individual- and population-level interventions for psychosis.

Place, publisher, year, edition, pages
2016. Vol. 42, no 6, 1353-1362 p.
National Category
URN: urn:nbn:se:sh:diva-29942DOI: 10.1093/schbul/sbw044ISI: 000388029100011PubMedID: 27109925ScopusID: 2-s2.0-84994430037OAI: diva2:925427
Available from: 2016-05-02 Created: 2016-05-02 Last updated: 2016-12-08Bibliographically approved

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