Effect of highly potent antipseudomonal beta-lactam agents alone and in combination with aminoglycosides against Pseudomonas aeruginosa
1984 (English)In: Reviews Of Infectious Diseases, ISSN 0162-0886, Vol. 6, no Supplement 3, S678-88 p.Article in journal (Refereed) Published
The activities of ticarcillin, cefsulodin, ceftazidime, aztreonam, and imipenem, formerly known as N-formimidoyl thienamycin, were evaluated alone and in combination with aminoglycosides against 56 clinical isolates of Pseudomonas aeruginosa, which were characterized by aminoglycoside susceptibility and content of aminoglycoside-modifying enzymatic activities. All beta-lactam agents were highly active against aminoglycoside-susceptible isolates, and with few exceptions the aminoglycoside-resistant isolates were susceptible to all of the beta-lactam agents except ticarcillin. Combinations of the beta-lactam agents with aminoglycosides frequently acted synergistically, but the effect of different beta-lactam agents in combination with an aminoglycoside against individual strains was unpredictable. The presence or absence of an aminoglycoside-modifying enzymatic activity had no observed effect on synergism with tobramycin. Killing-curve experiments with strains in the presence of concentrations of a beta-lactam and an aminoglycoside that were not bactericidal alone (one-fourth the minimal bactericidal concentration) showed synergistic bactericidal action against four strains that were tested. The results demonstrate the great activity of these newer antipseudomonal beta-lactam agents and their potential for synergism with aminoglycosides.
Place, publisher, year, edition, pages
1984. Vol. 6, no Supplement 3, S678-88 p.
Aminoglycosides/pharmacology, Anti-Bacterial Agents/*pharmacology, Aztreonam/pharmacology, Cefsulodin/pharmacology, Ceftazidime/pharmacology, Comparative Study, Drug Synergism, Humans, Imipenem, Microbial Sensitivity Tests, Non-U.S. Gov't, Penicillin Resistance, Pseudomonas aeruginosa/*drug effects, Research Support, Thienamycins/pharmacology, Ticarcillin/pharmacology
IdentifiersURN: urn:nbn:se:sh:diva-29029ISI: A1984AMS0200008PubMedID: 6443769OAI: oai:DiVA.org:sh-29029DiVA: diva2:891666
0162-0886 Journal Article2016-01-072016-01-072016-01-08Bibliographically approved