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Structural analysis of Efb, a fibrinogen binding protein of Staphylococcus aureus
Karolinska Institutet.ORCID iD: 0000-0002-3049-967X
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1998 (English)In: Protein peptide letters, ISSN 0929-8665, E-ISSN 1875-5305, Vol. 5, no 4, 199-206 p.Article in journal (Refereed) Published
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Text
Abstract [en]

Staphylococcus aureus produces and secretes a small, basic protein, designated Efb, that binds to fibrinogen and seems to be required for virulence of the organism. A 3D model of Efb was developed, and it predicts that the C-terminal half of the protein contains substantial alpha-helical content. CD analysis of Efb yielded a value of 40-41% alpha-helix. Calcium and zinc both influence the interactions between Efb and fibrinogen, and an analysis of the amino acid sequence of Efb revealed the presence of consensus sequences for the binding of both metals.

Place, publisher, year, edition, pages
1998. Vol. 5, no 4, 199-206 p.
Keyword [en]
circular-dichroism, coordination, prediction, virulence, zinc
National Category
Structural Biology
Identifiers
URN: urn:nbn:se:sh:diva-29042ISI: 000075171200003Scopus ID: 2-s2.0-3142565180OAI: oai:DiVA.org:sh-29042DiVA: diva2:891578
Note

Times Cited: 0 Article English Cited References Count: 22 106vm

Available from: 2016-01-07 Created: 2016-01-07 Last updated: 2016-01-11Bibliographically approved

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