Neurofunctional correlates of expressed vocal affect in social phobia
2011 (English)In: Cognitive, Affective, & Behavioral Neuroscience, ISSN 1530-7026, E-ISSN 1531-135X, Vol. 11, no 3, 413-425 p.Article in journal (Refereed) Published
We investigated the neural correlates of expressed vocal affect in patients with social phobia. A group of 36 patients performed an anxiogenic public-speaking task while regional cerebral blood flow (rCBF) was assessed using oxygen-15 positron emission tomography. The patients’ speech was recorded and content masked using low-pass filtering (which obscures linguistic content but preserves nonverbal affective cues). The content-masked speech samples were then evaluated with regard to their level of vocally expressed nervousness. We hypothesized that activity in prefrontal and subcortical brain areas previously implicated in emotion regulation would be associated with the degree of expressed vocal affect. Regression analyses accordingly revealed significant negative correlations between expressed vocal affect and rCBF in inferior frontal gyrus, putamen, and hippocampus. Further, functional connectivity was revealed between inferior frontal gyrus and (a) anterior cingulate cortex and (b) amygdala and basal ganglia. We suggest that brain areas important for emotion regulation may also form part of a network associated with the modulation of affective prosody in social phobia.
Place, publisher, year, edition, pages
2011. Vol. 11, no 3, 413-425 p.
anxiety, PET, prefrontal cortex, social phobia, vocal affect expression
IdentifiersURN: urn:nbn:se:sh:diva-26862DOI: 10.3758/s13415-011-0032-3ISI: 000293238700012ScopusID: 2-s2.0-80051617990OAI: oai:DiVA.org:sh-26862DiVA: diva2:802541
This study was supported by the Swedish Research Council, the Swedish Council for Working Life and Social Research, the Bank of Sweden Tercentenary Foundation, and the Brain Foundation.2011-08-152015-04-102015-05-13Bibliographically approved