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Smoking is associated with mosaic loss of chromosome Y
Uppsala University.
Uppsala University.
Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Biology.ORCID iD: 0000-0002-5013-6462
Uppsala University.
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2015 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 347, no 6217, 81-83 p.Article in journal (Refereed) Published
Abstract [en]

Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.

Place, publisher, year, edition, pages
2015. Vol. 347, no 6217, 81-83 p.
National Category
Biological Sciences
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URN: urn:nbn:se:sh:diva-25492DOI: 10.1126/science.1262092ISI: 000347102300053PubMedID: 25477213OAI: oai:DiVA.org:sh-25492DiVA: diva2:771624
Available from: 2014-12-15 Created: 2014-12-15 Last updated: 2016-09-22Bibliographically approved

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