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Environmentally relevant concentrations of citalopram partially inhibit feeding in the three-spine stickleback (Gasterosteus aculeatus)
Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Environmental Science.ORCID iD: 0000-0002-0856-9707
Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Environmental Science.
Södertörn University, School of Natural Sciences, Technology and Environmental Studies, Biology.ORCID iD: 0000-0001-9498-3033
Univ. of Copenhagen.
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2015 (English)In: Aquatic Toxicology, ISSN 0166-445X, E-ISSN 1879-1514, Vol. 158, 165-170 p.Article in journal (Refereed) Published
Abstract [en]

Selective Serotonin Re-uptake Inhibitors (SSRI) are mood-altering, psychotropic drugs commonly used in the treatment of depression and other psychological illnesses. Many of them are poorly degraded in sewage treatment plants and enter the environment unaltered. In laboratory studies, they have been demonstrated to affect a wide range of behaviours in aquatic organisms. In this study we investigated the effect of a three-week exposure to 0.15 and 1.5 μg/l of the SSRI citalopram dissolved in the ambient water on the feeding behaviour in three-spine stickleback (Gasterosteus aculeatus). Feeding, measured as the number of attacks performed on a piece of frozen bloodworms during a 10-min period, was reduced by 30–40% in fish exposed to both 0.15 and 1.5 μg/l citalopram. The effects of the environmentally relevant concentration 0.15 μg/l on feeding, an important fitness characteristic, suggests that the ecological significance of environmental SSRI exposure may be pronounced.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 158, 165-170 p.
Keyword [en]
SSRI, citalopram, fish, stickleback, feeding, antidepressant
National Category
Environmental Sciences
Research subject
Environmental Studies
URN: urn:nbn:se:sh:diva-25351DOI: 10.1016/j.aquatox.2014.11.003ISI: 000348888400018PubMedID: 25438122ScopusID: 2-s2.0-84912082657OAI: diva2:767709
The Foundation for Baltic and East European Studies
Available from: 2014-12-02 Created: 2014-12-02 Last updated: 2016-12-01Bibliographically approved

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Kellner, MartinPorseryd, TovePorsch-Hällström, IngerOlsén, K. Håkan
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