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In silico analysis of thioredoxins and glutaredoxins
Södertörn University, School of Life Sciences.
2005 (English)In: Journal of Plant Biochemistry and Biotechnology, ISSN 0971-7811, Vol. 14, no 2, 121-126 p.Article in journal (Refereed) Published
Abstract [en]

Thioredoxins (TRXs) and glutaredoxins (GRXs) are ubiquitous small redox proteins belonging to the thioredoxin (TRX) superfamily. They regulate several cellular functions via mediating a dithiol/disulphide exchange in target proteins. Thioredoxins have been classified into several subgroups based on their structural homologs. In an attempt to identify thioredoxin proteins which have not been characterized, an EST database survey of Lycopersicon esculentum, Glycine max, Helianthus annus, Secale cereale, Solanum tuberosum, Apis mellifera ligustica, Oncorhynchus mykiss, Salmo salar, and whole genome survey for Drosophila melanogaster, Rattus norvegicus and Caenorhabditis briggsae was performed. Several glutaredoxin and glutaredoxin-like proteins from Ricinus communis, Vercinia fordii, Lycopersicon esculentum, Tilia platyphyllos, Populus tremuloides, Triticum aestivum and Oryza sativa were also characterized. The deduced amino acid sequences were aligned and phylogenetic trees were constructed to determine the consensus sequences and for establishing interrelationships amongst the new and established thioredoxin and glutaredoxins. Based on the alignments, proteins were designated to their respective classes and subcellular localization predictions were used to predict their possible site of actions. In silico analysis has identified several new thioredoxins, glutaredoxins and related proteins and provided insight into their evolutionary relationships.

Place, publisher, year, edition, pages
2005. Vol. 14, no 2, 121-126 p.
Keyword [en]
Glutaredoxin, Phylogenetic, Redox proteins, Thioredoxin, Apis mellifera, Apis mellifera ligustica, Caenorhabditis, Caenorhabditis briggsae, Drosophila melanogaster, Glycine max, Helianthus, Helianthus annus, Lycopersicon esculentum, Malvaceae, Oncorhynchus mykiss, Oryza sativa, Populus tremuloides, Rattus norvegicus, Ricinus communis, Salmo salar, Secale cereale, Solanum tuberosum, Tilia platyphyllos, Triticum aestivum
National Category
Natural Sciences
URN: urn:nbn:se:sh:diva-23215ScopusID: 2-s2.0-25844500321OAI: diva2:716783
Available from: 2014-05-12 Created: 2014-04-16 Last updated: 2014-05-12Bibliographically approved

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Kitambi, Satish Srinivas
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