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Adriamycin cytotoxicity may stimulate growth of hepatocellular tumours in an experimental model for adjuvant systemic chemotherapy in liver transplantation
Södertörn University, School of Life Sciences. Karolinska Institute.
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2005 (English)In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 18, no 8, 992-1000 p.Article in journal (Refereed) Published
Abstract [en]

Adjuvant treatment with adriamycin has been suggested to improve results after liver transplantation for hepatocellular cancer. Here we have applied an animal model for evaluation of treatment with adriamycin and/or cyclosporine A on liver tumour growth. Three chemically induced rat liver tumours with various degree of differentiation were transferred to the spleens of syngenic rats. Each recipient group was divided into four subgroups, treated with adriamycin and/or cyclosporine A or none of the drugs. When the tumour was well differentiated no proliferation was found in any of the subgroups. When the tumour exhibited a more pronounced dysplasia, adriamycin stimulated tumour growth. This effect was further increased by cyclosporine. In the animals transplanted with the most aggressive tumour, adriamycin inhibited tumour growth. When given together with cyclosporine this inhibition was counteracted. These data suggest that adriamycin, especially when given together with cyclosporine, may have a stimulatory effect on liver tumour cell growth.

Place, publisher, year, edition, pages
2005. Vol. 18, no 8, 992-1000 p.
Keyword [en]
Adjuvant therapy, Adriamycin, Antioxidants, Cyclosporine A, Hepatocellular carcinoma, Liver transplantation, cyclosporin A, doxorubicin, antioxidant, glutathione reductase, animal experiment, animal model, animal tissue, article, cell differentiation, cell proliferation, controlled study, cytotoxicity, dysplasia, liver cell carcinoma, male, nonhuman, priority journal, rat, spleen, tumor growth, adjuvant chemotherapy, animal, drug effect, liver tumor, metabolism, multimodality cancer therapy, pathology, Wistar Kyoto rat, Animals, Chemotherapy, Adjuvant, Combined Modality Therapy, Liver Neoplasms, Experimental, Rats, Rats, Inbred WKY
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:sh:diva-23340DOI: 10.1111/j.1432-2277.2005.00155.xISI: 000230906000016PubMedID: 16008751ScopusID: 2-s2.0-25144432917OAI: oai:DiVA.org:sh-23340DiVA: diva2:716747
Available from: 2014-05-12 Created: 2014-04-16 Last updated: 2014-05-12Bibliographically approved

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