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Comparative effects of moxifloxacin and clarithromycin on the normal intestinal microflora
Södertörn University, Avdelning Naturvetenskap. Karolinska Institute.
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2000 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 32, no 1, 81-85 p.Article in journal (Refereed) Published
Abstract [en]

Twelve healthy male subjects age range 24-40 y participated in the investigation. The trial was divided into 2 35-d periods. The 2 treatment regimens were: (i) 1 x 400 mg moxifloxacin tablet in the morning and 1 placebo tablet in the evening for 7 d; and (ii) 1 x 500 mg clarithromycin tablet in the morning and 1 x 500 mg clarithromycin tablet in the evening for 7 d. Each subject received firstly 1 treatment regimen and secondly the other treatment regimen. The wash-out period was 6 weeks between the two treatment regimens. Moxifloxacin caused significant decreases of enterococci and enterobacteria during the administration period while the numbers of staphylococci, streptococci, Bacillus and Candida were not affected. No impact on peptostreptococci, lactobacilli, Veillonella, Bacteroides or fusobacteria was observed, while bifidobacteria and clostridia decreased during moxifloxacin administration. The microflora was normalized after 35 d. Clarithromycin caused significant reduction of Escherichia coli while the numbers of enterococci, Enterobacter, Citrobacter, Klebsiella and Pseudomonas increased markedly. No significant changes in the numbers of staphylococci, streptococci, Bacillus and Candida were noticed. In the anaerobic microflora bifidobacteria, lactobacilli and clostridia were suppressed, while no changes in peptostreptococci, Veillonella, Bacteroides and fusobacteria were found. The microflora was normalized in all volunteers after 35 d.

Place, publisher, year, edition, pages
2000. Vol. 32, no 1, 81-85 p.
Keyword [en]
antibiotic agent, clarithromycin, moxifloxacin, adult, article, Bacillus, bacterial colonization, Bacteroides, Bifidobacterium, Candida, Citrobacter, clinical trial, Clostridium, double blind procedure, Enterobacteriaceae, Enterococcus, Escherichia coli, feces microflora, Fusobacterium, human, intestine flora, Klebsiella, Lactobacillus, male, normal human, Peptostreptococcus, Pseudomonas, Staphylococcus, Streptococcus, time, Veillonella, Administration, Oral, Anti-Bacterial Agents, Anti-Infective Agents, Aza Compounds, Double-Blind Method, Endospore-Forming Bacteria, Feces, Fluoroquinolones, Gram-Negative Bacteria, Gram-Positive Bacteria, Gram-Positive Cocci, Humans, Intestines, Quinolines, Time Factors
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:sh:diva-22919ISI: 000085452800015PubMedID: 10716083Scopus ID: 2-s2.0-0033976765OAI: oai:DiVA.org:sh-22919DiVA: diva2:713560
Available from: 2014-04-23 Created: 2014-03-28 Last updated: 2014-04-23Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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