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Gene conversion of major histocompatibility complex genes in the mouse spermatogenesis is a premeiotic event
Södertörn University, Avdelning Naturvetenskap. Karolinska Institute / Stockholm University.
1997 (English)In: Molecular Biology of the Cell, ISSN 1059-1524, E-ISSN 1939-4586, Vol. 8, no 12, 2511-2517 p.Article in journal (Refereed) Published
Abstract [en]

The molecular genetic mechanism of gene conversion in higher eukaryotes remains unknown. We find it of considerable interest to determine when during spermatogenesis gene conversion occurs. We have therefore purified pachytene spermatocytes and haploid spermatocytes from adult mice and analyzed these fractions for the presence of gene conversion products resulting from the transfer between the major histocompatibility complex class II genes Ebd and Abk in a polymerase chain reaction assay. We have further isolated spermatogenic cells from prepubescent mice and analyzed them for the presence of the same gene conversion products. We can detect gene conversion products in testis cells as early as in 8-d-old mice where the only existing spermatogenic cells are spermatogonia. The frequency of gene conversion products remains the same as the cells reach meiosis in 18-d-old mice, and is unchanged after meiosis is completed in haploid spermatocytes. Gene conversion of this specific fragment therefore appears to be a premeiotic event and, consequently, relies on genetic mechanisms other than normal meiotic recombination.

Place, publisher, year, edition, pages
1997. Vol. 8, no 12, 2511-2517 p.
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:sh:diva-23003ISI: A1997YK93000012PubMedID: 9398672Scopus ID: 2-s2.0-1842293381OAI: oai:DiVA.org:sh-23003DiVA: diva2:711853
Available from: 2014-04-11 Created: 2014-04-11 Last updated: 2017-07-20Bibliographically approved

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Citation style
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