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A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay
Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
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2013 (English)In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, no 19, 3959-3964 p.Article in journal (Refereed) Published
Abstract [en]

A modular approach to explore the macrocyclic chemical space around an aminoindoline scaffold is developed. This is achieved by incorporating an amino acid moiety and subsequent stitching technology. Through screening of a zebrafish assay, several antiangiogenesis agents are identified.

Place, publisher, year, edition, pages
2013. no 19, 3959-3964 p.
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:sh:diva-19538DOI: 10.1002/ejoc.201300409ISI: 000320720100003ScopusID: 2-s2.0-8487919808OAI: oai:DiVA.org:sh-19538DiVA: diva2:642650
Available from: 2013-08-22 Created: 2013-08-20 Last updated: 2014-01-29Bibliographically approved

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Chandrasekar, GayathriKitambi, Satish Srinivas
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School of Natural Sciences, Technology and Environmental Studies
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