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Tetrahydroquinoline-Derived Macrocyclic Toolbox: The Discovery of Antiangiogenesis Agents in Zebrafish Assay
Södertörn University, School of Natural Sciences, Technology and Environmental Studies.
Södertörn University, School of Natural Sciences, Technology and Environmental Studies. Karolinska Institutet.
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2013 (English)In: ACS Medicinal Chemistry Letters, ISSN 1948-5875, Vol. 4, no 7, 666-670 p.Article in journal (Refereed) Published
Abstract [en]

A novel approach to incorporate the macrocyclic rings onto the privileged substructure, i.e. tetrahydroquinoline scaffold, is developed. The presence of an amino acid-derived moiety in the macrocyclic skeleton provides an opportunity to modulate the nature of the chiral side chain. Further, evaluation in a zebrafish screen identified three active small molecules (2.5b, 3.2d, and 4.2) as antiangiogenesis agents at 2.5 mu M.

Place, publisher, year, edition, pages
2013. Vol. 4, no 7, 666-670 p.
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:sh:diva-19544DOI: 10.1021/ml400026nISI: 000321883800022PubMedID: 24900727ScopusID: 2-s2.0-84880142629OAI: oai:DiVA.org:sh-19544DiVA: diva2:642649
Available from: 2013-08-22 Created: 2013-08-20 Last updated: 2014-06-13Bibliographically approved

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Chandrasekar, GayathriKitambi, Satish Srinivas
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School of Natural Sciences, Technology and Environmental Studies
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