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14-Membered Macrocyclic Ring-Derived Toolbox: The Identification of Small Molecule Inhibitors of Angiogenesis and Early Embryo Development in Zebrafish Assay
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2013 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 15, no 3, p. 436-439Article in journal (Other academic) Published
Abstract [en]

A highly practical and modular synthesis to obtain a diverse 14-membered ring-based macrocyclic toolbox is achieved. These compounds were further tested in zebrafish assays related to early embryonic development, angiogenesis, and neurogenesis, respectively. 1.4c was Identified as an antiangiogenesis agent.

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2013. Vol. 15, no 3, p. 436-439
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Organic Chemistry
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URN: urn:nbn:se:sh:diva-19440DOI: 10.1021/ol3032126ISI: 000314559000003Scopus ID: 2-s2.0-84873370245OAI: oai:DiVA.org:sh-19440DiVA, id: diva2:636671
Available from: 2013-07-11 Created: 2013-07-11 Last updated: 2017-12-06Bibliographically approved

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Chandrasekar, GayathriKitambi, Satish Srinivas

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Chandrasekar, GayathriKitambi, Satish Srinivas
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