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14-Membered Macrocyclic Ring-Derived Toolbox: The Identification of Small Molecule Inhibitors of Angiogenesis and Early Embryo Development in Zebrafish Assay
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2013 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 15, no 3, 436-439 p.Article in journal (Other academic) Published
Abstract [en]

A highly practical and modular synthesis to obtain a diverse 14-membered ring-based macrocyclic toolbox is achieved. These compounds were further tested in zebrafish assays related to early embryonic development, angiogenesis, and neurogenesis, respectively. 1.4c was Identified as an antiangiogenesis agent.

Place, publisher, year, edition, pages
2013. Vol. 15, no 3, 436-439 p.
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Organic Chemistry
URN: urn:nbn:se:sh:diva-19440DOI: 10.1021/ol3032126ISI: 000314559000003ScopusID: 2-s2.0-84873370245OAI: diva2:636671
Available from: 2013-07-11 Created: 2013-07-11 Last updated: 2015-06-02Bibliographically approved

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Chandrasekar, GayathriKitambi, Satish Srinivas
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School of Natural Sciences, Technology and Environmental Studies
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