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A possible tertiary rRNA interaction between expansion segments ES3 and ES6 in eukaryotic 40S ribosomal subunits
Södertörn University, Avdelning Naturvetenskap. Stockholm Universtiy.
Södertörn University, Avdelning Naturvetenskap.
2003 (English)In: RNA: A publication of the RNA Society, ISSN 1355-8382, E-ISSN 1469-9001, Vol. 9, no 1, 20-24 p.Article in journal (Refereed) Published
Abstract [en]

Eukaryotic 16S-like ribosomal RNAs contain 12 so-called expansion segments, i.e., sequences not included in the RNA secondary structure core common to eubacteria, archaea, and eukarya. Two of these expansion segments, ES3 and ES6, are juxtaposed in the recent three-dimensional model of the eukaryotic 40S ribosomal subunit. We have analyzed ES3 and ES6 sequences from more than 2900 discrete eukaryotic species, for possible sequence complementarity between the two expansion segments. The data show that ES3 and ES6 could interact by forming a helix consisting of seven to nine contiguous base pairs in almost all analyzed species. We, therefore, suggest that ES3 and ES6 form a direct RNA-RNA contact in the ribosome.

Place, publisher, year, edition, pages
2003. Vol. 9, no 1, 20-24 p.
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Biochemistry and Molecular Biology
URN: urn:nbn:se:sh:diva-17371DOI: 10.1261/rna.2108203ISI: 000183882300004PubMedID: 12554872ScopusID: 2-s2.0-0037276155OAI: diva2:571340
Available from: 2012-11-22 Created: 2012-11-19 Last updated: 2014-04-16Bibliographically approved

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Alkemar, GunnarNygård, Odd
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