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RANTES promotes growth and survival of human first-trimester forebrain astrocytes
Södertörn University, Avdelning Naturvetenskap. Karolinska Institute.
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2001 (English)In: Nature Cell Biology, ISSN 1465-7392, Vol. 3, no 2, 150-157 p.Article in journal (Refereed) Published
Abstract [en]

We have examined the role of alpha and beta chemokines in the promotion of the ontogenetic development of the brain. RANTES was expressed preferentially in human fetal astrocytes in an age-dependent manner. Astrocytes from 5-week-old brains showed high proliferation and reduced survival, whereas 10-week-old astrocytes exhibited opposite effects. These effects were suppressed by anti-RANTES or anti-RANTES receptor antibodies and were enhanced by recombinant RANTES. RANTES induced tyrosine phosphorylation of several cellular proteins and nuclear translocation of STAT-1 in astrocytes. Interferons (IFN-gamma) was required for RANTES effects because RANTES induced IFN-gamma, and only 10-week-old astrocytes expressed the IFN-gamma receptor. Blocking of IFN-gamma with antibody reversed the effects of RANTES, indicating that cytokine/chemokine networks are critically involved in brain development.

Place, publisher, year, edition, pages
2001. Vol. 3, no 2, 150-157 p.
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Cell Biology
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URN: urn:nbn:se:sh:diva-15871DOI: 10.1038/35055057ISI: 000166793000016PubMedID: 11175747ScopusID: 2-s2.0-0035154091OAI: oai:DiVA.org:sh-15871DiVA: diva2:509022
Available from: 2012-03-12 Created: 2012-03-09 Last updated: 2014-04-16Bibliographically approved

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