sh.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Expression-state boundaries in the mating-type region of fission yeast
Södertörn University, Avdelning Naturvetenskap.
2002 (English)In: Genetics, ISSN 0016-6731, E-ISSN 1943-2631, Vol. 161, no 2, 611-622 p.Article in journal (Refereed) Published
Abstract [en]

A transcriptionally silent chromosomal domain is found in the mating-type region of fission yeast. Here we show that this domain is delimited by 2-kb inverted repeats, IR-I, and IR-R, IR-I, and IR-R prevent the expansion of transcription-permissive chromatin into the silenced region and that of silenced chromatin into the expressed region. Their insulator activity is partially orientation dependent. The silencing defects that follow deletion or inversion of IR-R are suppressed by high dosage of the chromodomain protein Swi6. Combining chromosomal deletions and Swi6 overexpression shows that IR-I, and IR-R provide firm borders in a region where competition between silencing and transcriptional competence occurs. IR-R possesses autonomously replicating sequence (ARS) activity, leading to a model where replication factors, or replication itself, participate in boundary formation.

Place, publisher, year, edition, pages
2002. Vol. 161, no 2, 611-622 p.
National Category
Genetics
Identifiers
URN: urn:nbn:se:sh:diva-15804ISI: 000176374600012PubMedID: 12072458ScopusID: 2-s2.0-0035989380OAI: oai:DiVA.org:sh-15804DiVA: diva2:508485
Available from: 2012-03-08 Created: 2012-03-07 Last updated: 2014-04-23Bibliographically approved

Open Access in DiVA

No full text

PubMedScopus

Search in DiVA

By author/editor
Bjerling, Pernilla
By organisation
Avdelning Naturvetenskap
In the same journal
Genetics
Genetics

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 32 hits
ReferencesLink to record
Permanent link

Direct link