Synthesis of 4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid ethyl ester and its isomer 1-oxo-2,9-dihydro-1H-beta-carboline-4-carboxylic acid ethyl ester
2002 (English)In: Tetrahedron, ISSN 0040-4020, E-ISSN 1464-5416, Vol. 58, no 45, 9179-9185 p.Article in journal (Refereed) Published
4-Oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid ethyl ester was obtained when TosMIC was reacted with 3-methylene-oxindole acetic acid ethyl ester. An alternative synthesis to this pyrroloquinolone was performed via a reduction of a 2,3,4-trisubstituted pyrrole obtained in turn by treatment of a vinyl sulfone with ethyl isocyanoacetate under basic conditions. A beta-carboline, isomeric with the pyrroloquinolone, was synthesised utilizing a tosylimine.
Place, publisher, year, edition, pages
2002. Vol. 58, no 45, 9179-9185 p.
IdentifiersURN: urn:nbn:se:sh:diva-15775DOI: 10.1016/S0040-4020(02)01197-3ISI: 000179069000004OAI: oai:DiVA.org:sh-15775DiVA: diva2:508329