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Synthesis and reactions of some 2-vinyl-3H-quinazolin-4-ones
Södertörn University, Avdelning Naturvetenskap.
2000 (English)In: Tetrahedron, ISSN 0040-4020, E-ISSN 1464-5416, Vol. 56, no 37, 7245-7253 p.Article in journal (Refereed) Published
Abstract [en]

A simple, high-yielding synthesis of 2-vinyl-3H-quinazolin-4-one, 2-(1-chlorovinyl)-3H-quinazolin-4-one and 2-(1-bromovinyl)-3H-quinazolin-4-one. The 2-vinylquinazolinones 11a and 14 participate readily in nucleophilic addition reactions. Treatment with both carbon and nitrogen nucleophiles results in a clean conversion into a variety of 2-substituted 3H-quinazolin-4-one derivatives. The 2-(1-halovinyl)-3H-quinazolin-4-ones 11b and Ile reacted with carbon nucleophiles to give several derivatives of 2-substituted 3H-quinazolin-4-one, such as dihydrofurancarboxylic ethyl ester 23.

Place, publisher, year, edition, pages
2000. Vol. 56, no 37, 7245-7253 p.
National Category
Organic Chemistry
URN: urn:nbn:se:sh:diva-15737DOI: 10.1016/S0040-4020(00)00595-0ISI: 000089149200018PubMedID: 20235747ScopusID: 2-s2.0-0034622912OAI: diva2:508119
Available from: 2012-03-07 Created: 2012-03-07 Last updated: 2014-02-18Bibliographically approved

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