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Ecological disturbances in intestinal microflora caused by clinafloxacin, an extended-spectrum quinolone
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2000 (English)In: Infection. Zeitschrift für Klinik und Therapie der Infektionen, ISSN 0300-8126, E-ISSN 1439-0973, Vol. 28, no 5, 272-277 p.Article in journal (Refereed) Published
Abstract [en]

Background: The quinolones developed over the past few years have enhanced in vitro activity and a broader spectrum of antimicrobial activity compared to ma ny other antimicrobial agents including the older quinolones. The present study focuses on the effect of clinafloxacin, a member of the new broad-spectrum quinolone class of antibiotics, on the normal intestinal microflora. Subjects and Methods: A total of it healthy volunteers received clinafloxacin orally, zoo mg twice daily for 7 days. Fecal specimens were collected at defined intervals before, during and after the administration in order to study the effect of clinafloxacin on the intestinal microflora and to correlate this effect with fecal clinafloxacin concentrations. Intestinal microorganisms isolated before, during and 2 weeks after clinafloxacin administration were tested for their suseptibility to clinafloxacin. Results: Oral administration of clinafloxacin resulted in high drug levels in feces (mean value 176.2 mg/kg on day 7) and pronounced ecological disturbances. The aerobic microflora was eradicated in 11 of the 12 subjects and the anaerobic microflora was strongly suppressed during administration. There was a significant emergence of clinafloxacin-resistant Bacteroides spp, strains (MIC greater than or equal to 4 mg/ml) during administration. The elevated MIC values still remained 2 weeks after discontinuation of the antibiotic (p < 0.001). Conclusion: The emergence of clinafloxacin-resistant Bacteroides spp. demonstrates the necessity of restricting prescription for particular indications in order to preserve the efficacy of the highly active broad-spectrum quinolones.

Place, publisher, year, edition, pages
2000. Vol. 28, no 5, 272-277 p.
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Medical and Health Sciences
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URN: urn:nbn:se:sh:diva-15740DOI: 10.1007/s150100070018ISI: 000089932300004PubMedID: 11073132OAI: oai:DiVA.org:sh-15740DiVA: diva2:508099
Available from: 2012-03-07 Created: 2012-03-07 Last updated: 2012-03-07Bibliographically approved

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Edlund, Charlotta
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Avdelning Naturvetenskap
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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf