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Structural diversity in lipopolysaccharide expression in nontypeable Haemophilus influenzae - Identification of L-glycero-D-manno-heptose in the outer-core region in three clinical isolates
Södertörn University, Avdelning Naturvetenskap. Karolinska Institutet.
John Radcliffe Hospital, Oxford, UK.
John Radcliffe Hospital, Oxford, UK.
Södertörn University, Avdelning Naturvetenskap. Karolinska Institutet.
2003 (English)In: European Journal of Biochemistry, ISSN 0014-2956, E-ISSN 1432-1033, Vol. 270, no 4, 610-624 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2003. Vol. 270, no 4, 610-624 p.
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:sh:diva-15640DOI: 10.1046/j.1432-1033.2003.03399.xISI: 000180844900006PubMedID: 12581201ScopusID: 2-s2.0-0037293036OAI: oai:DiVA.org:sh-15640DiVA: diva2:505223
Available from: 2012-02-23 Created: 2012-02-22 Last updated: 2017-02-15Bibliographically approved
In thesis
1. The structural diversity of lipopolysaccharides expressed by genetically defined clinical isolates of nontypeable Haemophilus influenzae
Open this publication in new window or tab >>The structural diversity of lipopolysaccharides expressed by genetically defined clinical isolates of nontypeable Haemophilus influenzae
2003 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Nontypeable Haemophilus influenzae (NTHi) is an important cause of otitis media and respiratory tract infections. Its lipopolysaccharide (LPS) molecule, an outer membrane component, is a major virulence factor of NTHi. The LPS molecule may also be an efficient target for antibodies which might be protective against NTHi disease. The present thesis describes the structural analyses of the LPS from a number of NTHi clinical isolates. These isolates have been selected to be representative of the genetic diversity in the natural population of NTHi. The studies revealed extended inter- and intrastrain variability in LPS expression but also the presence of a conserved structural element. Several novel structural features were found, including epitopes not previously observed in Haemophilus influenzae LPS. The studies were performed using nuclear magnetic resonance spectroscopy, electrospray ionization mass spectrometry and different chemical degradations of the LPS as the principal methods.

Place, publisher, year, edition, pages
Stockholm: Karolinska Instiutet, 2003. 52 p.
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:sh:diva-32070 (URN)91-7349-584-0 (ISBN)
Public defence
2003-08-29, Hörsalen, plan 4, NOVUM, Hälsovägen 7, Huddinge, 10:00 (English)
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Available from: 2017-02-15 Created: 2017-02-15 Last updated: 2017-02-15Bibliographically approved

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