sh.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Coagulation in arthropods: defence, wound closure and healing
Södertörn University, School of Chemistry, Biology, Geography and Environmental Science.
2004 (English)In: Trends in immunology, ISSN 1471-4906, E-ISSN 1471-4981, Vol. 25, no 6, 289-294 p.Article in journal (Refereed) Published
Abstract [en]

Arthropods have open circulatory systems and must seal wounds and keep bacteria from entering the hemocoel using efficient clotting systems. Enzymes that crosslink the clot include transglutaminase, which is phylogenetically conserved, and phenoloxidase, which is not found in vertebrates. Prophenoloxidase is usually activated through a proteolytic cascade similar to the vertebrate clotting cascade. The well-characterized clotting cascade in horseshoe crabs is strongly activated by bacterial elicitors, in contrast to vertebrate clotting where induction relies more on endogenous signals. Many arthropod clotting factors are not orthologues of blood clotting factors, but show novel architectures assembled from domains that are also found in their vertebrate counterparts. The cellular mechanisms that lead to coagulation of blood and hemolymph appear to be similar. Recent findings in Drosophila reveal parallels between developmental processes that involve epithelial fusion and wound healing, enabling genetic dissection of the signal pathways involved. This Review is the first in a series on interactions between haemostasis and inflammation.

Place, publisher, year, edition, pages
2004. Vol. 25, no 6, 289-294 p.
National Category
Immunology
Identifiers
URN: urn:nbn:se:sh:diva-15479DOI: 10.1016/j.it.2004.03.004ISI: 000222302100004PubMedID: 15145318ScopusID: 2-s2.0-1842800032OAI: oai:DiVA.org:sh-15479DiVA: diva2:504656
Available from: 2012-02-21 Created: 2012-02-20 Last updated: 2014-04-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Dushay, Mitchell S
By organisation
School of Chemistry, Biology, Geography and Environmental Science
In the same journal
Trends in immunology
Immunology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 75 hits
ReferencesLink to record
Permanent link

Direct link