Sin3: a flexible regulator of global gene expression and genome stability
2005 (English)In: Current Genetics, ISSN 0172-8083, E-ISSN 1432-0983, Vol. 47, no 1, 1-17 p.Article in journal (Refereed) Published
SIN3 was first identified genetically as a global regulator of transcription. Sin3 is a large protein composed mainly of protein-interaction domains, whose function is to provide structural support for a heterogeneous Sin3/histone deacetylase (HDAC) complex. The core Sin3/HDAC complex is conserved from yeast to man and consists of eight proteins. In addition to HDACs, Sin3 can sequester other enzymatic functions, including nucleosome remodeling, DNA methylation, N-acetylglucoseamine transferase activity, and histone methylation. Since the Sin3/HDAC complex lacks any DNA-binding activity, it must be targeted to gene promoters by interacting with DNA-binding proteins. Although most research on Sin3 has focused on its role as a corepressor, mounting evidence suggests that Sin3 can also positively regulate transcription. Furthermore, Sin3 is key to the propagation of epigenetically silenced domains and is required for centromere function. Thus, Sin3 provides a platform to deliver multiple combinations modifications to the chromatin, using both sequence-specific and sequence-independent mechanisms.
Place, publisher, year, edition, pages
2005. Vol. 47, no 1, 1-17 p.
IdentifiersURN: urn:nbn:se:sh:diva-14396DOI: 10.1007/s00294-004-0541-5ISI: 000225895200001PubMedID: 15565322ScopusID: 2-s2.0-11244271837OAI: oai:DiVA.org:sh-14396DiVA: diva2:469122