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Increased conjugation frequencies in clinical Enterococcus faecium strains harbouring the enterococcal surface protein gene esp
Södertörn University, School of Life Sciences. Karolinska Univesity Hospital, Huddinge.
Karolinska Univesity Hospital, Huddinge.
Södertörn University, School of Life Sciences. Karolinska Univesity Hospital, Huddinge.
2006 (English)In: Clinical Microbiology and Infection, ISSN 1198-743X, E-ISSN 1469-0691, Vol. 12, no 6, 588-591 p.Article in journal (Refereed) Published
Abstract [en]

This study compared the in-vitro ability of Enterococcus faecium isolates of different origin to acquire vanA by conjugation in relation to the occurrence of the esp gene. In total, 29 clinical isolates (15/29 esp+), 30 normal intestinal microflora isolates (2/30 esp+) and one probiotic strain (esp-) were studied with a filter-mating assay. Conjugation events were confirmed by PCR and pulsed-field gel electrophoresis. Among the infection-derived isolates, the esp+ isolates had higher conjugation frequencies compared with esp- isolates (p < 0.001), with a median value of 6.4 x 10(-6) transconjugants/donor. The probiotic strain was shown to acquire vanA vancomycin resistance in in-vitro filter mating experiments.

Place, publisher, year, edition, pages
2006. Vol. 12, no 6, 588-591 p.
National Category
Microbiology
Identifiers
URN: urn:nbn:se:sh:diva-14298DOI: 10.1111/j.1469-0691.2006.01436.xISI: 000237515600017PubMedID: 16700712ScopusID: 2-s2.0-33646702110OAI: oai:DiVA.org:sh-14298DiVA: diva2:468161
Available from: 2011-12-20 Created: 2011-12-20 Last updated: 2014-04-10Bibliographically approved

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Edlund, Charlotta
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