sh.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons
Södertörn University, School of Life Sciences.
Södertörn University, School of Life Sciences.
Södertörn University, School of Life Sciences.
Show others and affiliations
2006 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 580, no 2, p. 484-490Article in journal (Refereed) Published
Abstract [en]

Thioredoxins are a class of small proteins that play a key role in regulating many cellular redox processes. We report here the characterization of the first member of the thioredoxin family in metazoans that is mainly associated with neurons. The Caenorhabditis elegans gene B0228.5 encodes a thioredoxin (TRX-1) that is expressed in ASJ ciliated sensory neurons, and to some extent also in the posterior-most intestinal cells. TRX-1 is active at reducing protein disulfides in the presence of a heterologous thioredoxin reductase. A mutant worm strain carrying a null allele of the trx-1 gene displays a reproducible decrease in both mean and maximum lifespan when compared to wild-type. The identification and characterization of TRX-1 paves the way to use C elegans as an in vivo model to study the role of thioredoxins in lifespan and nervous system physiology and pathology.

Place, publisher, year, edition, pages
2006. Vol. 580, no 2, p. 484-490
National Category
Biochemistry and Molecular Biology Biophysics Cell Biology
Identifiers
URN: urn:nbn:se:sh:diva-14310DOI: 10.1016/j.febslet.2005.12.046ISI: 000234937400022PubMedID: 16387300Scopus ID: 2-s2.0-30644465295OAI: oai:DiVA.org:sh-14310DiVA, id: diva2:468106
Available from: 2011-12-20 Created: 2011-12-20 Last updated: 2017-12-08Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Miranda-Vizuete, AntonioFierro Gonzalez, Juan CarlosBurghoorn, JanSwoboda, Peter

Search in DiVA

By author/editor
Miranda-Vizuete, AntonioFierro Gonzalez, Juan CarlosBurghoorn, JanSwoboda, Peter
By organisation
School of Life Sciences
In the same journal
FEBS Letters
Biochemistry and Molecular BiologyBiophysicsCell Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 57 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf