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Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons
Södertörn University, School of Life Sciences.
Södertörn University, School of Life Sciences.
Södertörn University, School of Life Sciences.
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2006 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 580, no 2, 484-490 p.Article in journal (Refereed) Published
Abstract [en]

Thioredoxins are a class of small proteins that play a key role in regulating many cellular redox processes. We report here the characterization of the first member of the thioredoxin family in metazoans that is mainly associated with neurons. The Caenorhabditis elegans gene B0228.5 encodes a thioredoxin (TRX-1) that is expressed in ASJ ciliated sensory neurons, and to some extent also in the posterior-most intestinal cells. TRX-1 is active at reducing protein disulfides in the presence of a heterologous thioredoxin reductase. A mutant worm strain carrying a null allele of the trx-1 gene displays a reproducible decrease in both mean and maximum lifespan when compared to wild-type. The identification and characterization of TRX-1 paves the way to use C elegans as an in vivo model to study the role of thioredoxins in lifespan and nervous system physiology and pathology.

Place, publisher, year, edition, pages
2006. Vol. 580, no 2, 484-490 p.
National Category
Biochemistry and Molecular Biology Biophysics Cell Biology
Identifiers
URN: urn:nbn:se:sh:diva-14310DOI: 10.1016/j.febslet.2005.12.046ISI: 000234937400022PubMedID: 16387300Scopus ID: 2-s2.0-30644465295OAI: oai:DiVA.org:sh-14310DiVA: diva2:468106
Available from: 2011-12-20 Created: 2011-12-20 Last updated: 2014-03-27Bibliographically approved

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Miranda-Vizuete, AntonioFierro Gonzalez, Juan CarlosBurghoorn, JanSwoboda, Peter
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CiteExportLink to record
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Citation style
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