Heterochromatin tells CENP-A where to go
2008 (English)In: Bioessays, ISSN 0265-9247, E-ISSN 1521-1878, Vol. 30, no 6, 526-529 p.Article in journal (Refereed) Published
The centromere is the region of the chromosome where the kinetochore forms. Kinetochores are the attachment sites for spindle microtubules that separate duplicated chromosomes in mitosis and meiosis. Kinetochore formation depends on a special chromatin structure containing the histone H3 variant CENP-A. The epigenetic mechanisms that maintain CENP-A chromatin throughout the cell cycle have been studied extensively but little is known about the mechanism that targets CENP-A to naked centromeric DNA templates. In a recent report published in Science,((1)) such de novo centromere assembly of CENP-A is shown to be dependent on heterochromatin and the RNA interference pathway.
Place, publisher, year, edition, pages
2008. Vol. 30, no 6, 526-529 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:sh:diva-14149DOI: 10.1002/bies.20763ISI: 000256608700003ScopusID: 2-s2.0-45549091508OAI: oai:DiVA.org:sh-14149DiVA: diva2:467024