sh.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish
Södertörn University, School of Life Sciences.
Södertörn University, School of Life Sciences.
Show others and affiliations
2008 (English)In: Developmental Dynamics, ISSN 1058-8388, E-ISSN 1097-0177, Vol. 237, no 4, 1090-1098 p.Article in journal (Refereed) Published
Abstract [en]

Mammalian liver-X-receptors (LXRs) are transcription factors activated by oxysterols. They play an essential role in lipid and glucose metabolism. We have cloned the open reading frame of zebrafish lxr and describe its genomic organization. Zebrafish lxr encodes a 50-kDa protein with high sequence similarity to mammalian LXR alpha. In transfection assays, the encoded protein showed transcriptional activity in response to LXR-ligands. Treatment of adult zebrafish with the synthetic LXR ligand, GW3965, induced expression of genes involved in hepatic cholesterol and lipid pathways. Using qPCR and in situ hybridization, we found ubiquitous expression of lxr mRNA during the first 24 hr of development, followed by more restricted expression, particularly to the liver at 3dpf and the liver and intestine at 4dpf. In adult fish, all examined organs expressed lxr. In addition to a metabolic role of lxr, the temporal expression pattern suggests a developmental role in, e.g., the liver and CNS.

Place, publisher, year, edition, pages
2008. Vol. 237, no 4, 1090-1098 p.
National Category
Developmental Biology
Identifiers
URN: urn:nbn:se:sh:diva-14162DOI: 10.1002/dvdy.21476ISI: 000254903700020PubMedID: 18297735ScopusID: 2-s2.0-42149130968OAI: oai:DiVA.org:sh-14162DiVA: diva2:466989
Available from: 2011-12-18 Created: 2011-12-16 Last updated: 2014-02-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Lauter, GilbertHauptmann, Giselbert
By organisation
School of Life Sciences
In the same journal
Developmental Dynamics
Developmental Biology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 46 hits
ReferencesLink to record
Permanent link

Direct link