sh.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • harvard-anglia-ruskin-university
  • apa-old-doi-prefix.csl
  • sodertorns-hogskola-harvard.csl
  • sodertorns-hogskola-oxford.csl
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Drosophila lamin mutations cause melanotic mass formation and lamellocyte differentiation
Södertörn University, School of Life Sciences.
Södertörn University, School of Life Sciences, Molecular biology.
Södertörn University, School of Life Sciences.
2009 (English)In: Molecular Immunology, ISSN 0161-5890, E-ISSN 1872-9142, Vol. 46, no 16, p. 3245-3250Article in journal (Refereed) Published
Abstract [en]

The fruit fly immune system is a valuable model for invertebrate and innate immunity. Cellular immune reactions in Drosophila are of great interest, especially the molecular genetic mechanisms of hemocyte differentiation and the encapsulation of foreign bodies. Here we report that changes in the lamin gene cause melanotic masses. These darkened clusters of cells result from autoimmune-like encapsulation of self-tissue, as shown by the presence in lam larvae of lamellocytes, effector hemocytes that appear in larvae following wounding or parasitization. Lamins thus affect immunity in Drosophila, and lam mutations can serve as genetic tools to dissect cellular immune signaling and effector pathways.

Place, publisher, year, edition, pages
2009. Vol. 46, no 16, p. 3245-3250
National Category
Biochemistry Molecular Biology
Identifiers
URN: urn:nbn:se:sh:diva-13881DOI: 10.1016/j.molimm.2009.08.003ISI: 000271175000009PubMedID: 19716177Scopus ID: 2-s2.0-70349567465OAI: oai:DiVA.org:sh-13881DiVA, id: diva2:465595
Available from: 2011-12-14 Created: 2011-12-14 Last updated: 2025-02-20Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Markovic, Maja PavlovicKylsten, PerDushay, Mitchell S.

Search in DiVA

By author/editor
Markovic, Maja PavlovicKylsten, PerDushay, Mitchell S.
By organisation
School of Life SciencesMolecular biology
In the same journal
Molecular Immunology
BiochemistryMolecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 342 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • harvard-anglia-ruskin-university
  • apa-old-doi-prefix.csl
  • sodertorns-hogskola-harvard.csl
  • sodertorns-hogskola-oxford.csl
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf