HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress
2009 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 10, no 9, 1009-1014 p.Article in journal (Refereed) Published
Histone acetylation and deacetylation are important for gene regulation. The histone acetyltransferase, Gcn5, is an activator of transcriptional initiation that is recruited to gene promoters. Here, we map genome-wide Gcn5 occupancy and histone H3K14ac at high resolution. Gcn5 is predominantly localized to coding regions of highly transcribed genes, where it collaborates antagonistically with the class-II histone deacetylase, Clr3, to modulate H3K14ac levels and transcriptional elongation. An interplay between Gcn5 and Clr3 is crucial for the regulation of many stress-response genes. Our findings suggest a new role for Gcn5 during transcriptional elongation, in addition to its known role in transcriptional initiation.
Place, publisher, year, edition, pages
2009. Vol. 10, no 9, 1009-1014 p.
IdentifiersURN: urn:nbn:se:sh:diva-13886DOI: 10.1038/embor.2009.127ISI: 000269449500020PubMedID: 19633696ScopusID: 2-s2.0-69949172827OAI: oai:DiVA.org:sh-13886DiVA: diva2:465592