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Immunogenicity and antigenic properties of Pf332-C231, a fragment of a non-repeat region of the Plasmodium falciparum antigen Pf332
Södertörn University, School of Life Sciences.
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2009 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 28, no 1, 90-97 p.Article in journal (Refereed) Published
Abstract [en]

Antigen Pf332, a megadalton protein has been shown to be associated with the membrane of infected erythrocytes Detailed functional studies on the antigen have remained hampered by the cross-reactive nature of antibodies generated to Pf332 PB32-C231, identified in the C-terminal region of Pf332 was cloned and antibodies against the C231 fragment were shown to react with intact Pf332 antigen by both immunofluorescence and immunoblotting analyses Antibodies to C231 inhibited in vitro Plasmodium falciparum growth efficiently In addition. human sera from malaria-exposed individuals reacted with recombinant C231 We show that Pf332-C231 represents a functional domain and is expected to facilitate further studies on Pf332 as a potential target for protective immune responses and the function of the antigen.

Place, publisher, year, edition, pages
2009. Vol. 28, no 1, 90-97 p.
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Immunology
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URN: urn:nbn:se:sh:diva-13873DOI: 10.1016/j.vaccine.2009.09.110ISI: 000274869200012PubMedID: 19822232ScopusID: 2-s2.0-70649086102OAI: oai:DiVA.org:sh-13873DiVA: diva2:465577
Available from: 2011-12-14 Created: 2011-12-14 Last updated: 2014-02-13Bibliographically approved

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