Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation
2010 (English)In: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 11, 59Article in journal (Refereed) Published
Background: Histone acetyltransferase enzymes (HATs) are implicated in egulation of transcription. HATs from different families may overlap in arget and substrate specificity. esults: We isolated the elp3(+) gene encoding the histone cetyltransferase subunit of the Elongator complex in fission yeast and haracterized the phenotype of an Delta elp3 mutant. We examined genetic nteractions between Delta elp3 and two other HAT mutants, Delta mst2 nd Delta gcn5 and used whole genome microarray analysis to analyze heir effects on gene expression. onclusions: Comparison of phenotypes and expression profiles in single, ouble and triple mutants indicate that these HAT enzymes have verlapping functions. Consistent with this, overlapping specificity in istone H3 acetylation is observed. However, there is no evidence for verlap with another HAT enzyme, encoded by the essential mst1(+) gene.
Place, publisher, year, edition, pages
2010. Vol. 11, 59
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
IdentifiersURN: urn:nbn:se:sh:diva-13716DOI: 10.1186/1471-2164-11-59ISI: 000274660300002PubMedID: 2823694ScopusID: 2-s2.0-76949101471OAI: oai:DiVA.org:sh-13716DiVA: diva2:462180
Som manuskript i avhandling. As manuscript in dissertation.
Expression profiling of S. pombe acetyltransferase identifies redundant pathways of gene regulation2011-12-062011-12-062016-09-15Bibliographically approved