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Costs and benefits of genetic heterogeneity within organisms
Södertörn University College, School of Life Sciences.ORCID iD: 0000-0002-0260-3978
2004 (English)In: Journal of Evolutionary Biology, ISSN 1010-061X, E-ISSN 1420-9101, Vol. 17, no 6, 1167-1177 p.Article in journal (Refereed) Published
Abstract [en]

An increasing number of studies have recently detected within-organism genetic heterogeneity suggesting that genetically homogeneous organisms may be rare. In this review, we examine the potential costs and benefits of such intraorganismal genetic heterogeneity (IGH) on the fitness of the individual. The costs of IGH include cancerous growth, parasitism, competitive interactions and developmental instability, all of which threaten the integrity of the individual while the potential benefits are increased genetic variability, size-specific processes, and synergistic interactions between genetic variants. The particular cost or benefit of IGH in a specific case depends on the organism type and the origin of the IGH. While mosaicism easily arise by genetic changes in an individual, and will be the more common type of IGH, chimerism originates by the fusion of genetically distinct entities, and is expected to be substantially rare in most organisms. Potential conflicts and synergistic effects between different genetic lineages within an individual provide an interesting example for theoretical and empirical studies of multilevel selection.

Place, publisher, year, edition, pages
2004. Vol. 17, no 6, 1167-1177 p.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:sh:diva-6059DOI: 10.1111/j.1420.9101.2004.00808.xISI: 000224646800001OAI: oai:DiVA.org:sh-6059DiVA: diva2:395508
Available from: 2011-02-07 Created: 2011-02-07 Last updated: 2016-09-29Bibliographically approved

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Lehtilä, Kari
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