sh.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Effects on Guppy Brain Aromatase Activity Following Short-Term Steroid and 4-Nonylphenol Exposures
Södertörn University, School of Life Sciences, Environmental science. Södertörn University, School of Life Sciences, Biology.
Södertörn University, School of Life Sciences, Environmental science. Södertörn University, School of Life Sciences, Biology.
2010 (English)In: Environmental Toxicology, ISSN 1520-4081, E-ISSN 1522-7278, Vol. 25, no 3, 261-271 p.Article in journal (Refereed) Published
Abstract [en]

Brain estrogen production, performed by the enzyme aromatase, can be disrupted/affected in teleost fish exposed to endocrine disruptors found in polluted aquatic environments. The guppy (Poecilia reticulata) was previously studied and confirmed to suffer negative effects on reproductive behaviors following inhibition of the brain aromatase reaction. Here adult guppies (Poecilia reticulata) of both genders were subjected to known endocrine disruptors: the androgen androstenedione (A), the synthetic estrogen 17 alpha-ethinylestradiol (EE2), and the estrogenic surfactant 4-nonylphenol (NP), at high (50 mu g/L) and at environmentally relevant concentrations (10 ng/L EE2, 5 mu g/L NP, and 0.7 mu g/L A) for 2 weeks followed by measurements of brain aromatase activity (bAA). In the adult males, bAA was stimulated by A and EE2 at 50 mu g/L. Female activity was also stimulated by the higher estrogenic treatment. At environmentally relevant concentrations only the EE2 treatment affected bAA, and only in males. The alkylphenolic substance NP produced no effect in either of the experiments, not on males nor females. The results indicate that short-term steroid treatments have stimulatory effects on guppy brain aromatase even at concentrations that can be found in the environment. We thus suggest bAA of adult guppies to be a suitable bioindicator of endocrine disruptors.

Place, publisher, year, edition, pages
2010. Vol. 25, no 3, 261-271 p.
National Category
Environmental Sciences Biological Sciences
Identifiers
URN: urn:nbn:se:sh:diva-5833DOI: 10.1002/tox.20494ISI: 000277689000007PubMedID: 19489062ScopusID: 2-s2.0-77954358974OAI: oai:DiVA.org:sh-5833DiVA: diva2:393729
Available from: 2011-02-01 Created: 2011-01-31 Last updated: 2014-11-28Bibliographically approved
In thesis
1. Brain aromatase in the guppy, Poecilia reticulata: distribution, control and role in behaviour
Open this publication in new window or tab >>Brain aromatase in the guppy, Poecilia reticulata: distribution, control and role in behaviour
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: Zoologiska institutionen, Stockholms universitet, 2009. 41 p.
Series
Södertörn Doctoral Dissertations, ISSN 1652-7399 ; 36
National Category
Biological Sciences
Identifiers
urn:nbn:se:sh:diva-8387 (URN)978-91-7155-870-1 (ISBN)978-91-86069-03-2 (ISBN)
Available from: 2011-05-05 Created: 2011-05-05 Last updated: 2015-06-14Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Hallgren, StefanOlsén, K Håkan
By organisation
Environmental scienceBiology
In the same journal
Environmental Toxicology
Environmental SciencesBiological Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 139 hits
ReferencesLink to record
Permanent link

Direct link