Uganda and Tanzania are two countries severely affected by HIV/AIDS. Hence, there are a numbers of associations for PLHA there. In "Global transformations. Politics, economics and culture", Held, Mc Greew, Goldblatt and Perrton focuses None Governmental Organizations as important actors in the globalized world of today, with increased opportunities to influence and affect the politics. The aim of this paper is to investigate the opportunities for associations for PLHA in Tanzania and Uganda to affect in the national level of politics. The study wants to elucidate the relation between the state/government/authorities and the civil society/associations/NGO:s.This has been done threw investigations of associations of PLHA in Tanzania and Uganda, their characters, objectives and opportunities to affect the HIV/AIDS politics in each country. I have been trying a hypothesis which have claimed that these organizations has not played a political role, meaning that they have affected the politically decision makings concerning HIV/AIDS. The empirical material has mainly been collected threw questionnaires to the selected organizations. It has not been possible to appoint the hypothesis, neither to reject it. There are some indications pointing on its validity. In an summarized assessment, the Ugandan organizations are more politically than the Tanzanian organizations, but probably not in a way that have affected the parlamentarically decision processes concerning HIV/AIDS, as the hypothesis intended. A opposite dependence has not been possible to eliminate: That the character and focus of the associations for PLHA in Tanzania and Uganda is a result of the countries differences in dealing with the problem of HIV/AIDS.