A Volume of Fluid (VOF) method is applied to study the interaction between two liquid drops with the same initial diameter in uniform flow. Various arrangements of the drops are studied, based on two parameters, namely the initial separation distance and the angle between the line connecting the centres of the drops and the free-stream direction. Initial separation distances of 1.5–5 drop diameters, and angles between β=0∘ and 90° are considered. Simulations for a Weber number of We=20, two Reynolds numbers Re=20 and 50, and density and viscosity ratios in the range ρ*=20–80 and μ*=0.5–50 are performed. The movement of the secondary drop with respect to the primary drop, and estimates on the time required for the breakup of the secondary drop as compared to those observed for single drops are evaluated. It is found that the drops collide only in cases corresponding to the shortest initial displacements, while in others they deform and break up independently, similarly or identically to single drops. The same behaviour is reflected in the time required for breakup. Cases where the drops behave independently show breakup times close to those observed for single drops.