Within the next decade, the number of self-employed workers, now 40% of the workforce, is predicted to surpass that of traditional employees. Managing finances (financial literacy) is an important skill set for self-employment. We bring attention to the growing prevalence of self-employment at a time when financial literacy is in decline in the United States. Using a sample of 15,069 participants in the 2015 and 2018 National Financial Capability Study, we find support for a positive association between financial literacy and self-employment in a U.S. context and extend prior research by focusing on two widely studied and important U.S. demographic segments in self-employment and entrepreneurship literature – gender and race. Contrary to other U.S.-based studies, we find that women with higher financial literacy scores are more likely to be self-employed than men; yet surprisingly, there is no significant difference in the association between higher financial literacy scores and self-employment between non-white and white U.S. respondents. We discuss the implications of the findings for researchers, policymakers, educators, and those considering self-employment.