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Molecular characterization of the interaction between Tick-borne encephalitis virus NS5 protein and the Interferon alpha/beta and gamma receptors
Södertörn University College, School of Life Sciences.
2007 (English)Independent thesis Basic level (degree of Bachelor), 10 points / 15 hpStudent thesis
Abstract [en]

Flaviviruses, family flaviviridae, are often associated with severe diseases and many of the viruses have been shown to affect the immune response. Interferons confer important ways of defending the host against viral infections because they provide a link between the innate and the adaptive immunity. Langat virus (LGTV), belonging to the Tick-Borne Encephalitis (TBE) complex of viruses, has recently been shown to provide interactions with interferon receptors and inhibit the interferon-mediated response. Similarly, it has been demonstrated that the TBE virus NS5 protein affects type 1 interferon signaling. In this study we have analyzed the interaction between the TBE NS5 protein and interferon receptors by using the yeast two-hybrid system. Our results support the idea that the inhibition of interferon signaling does not involve a direct interaction between TBEV NS5 and the interferon receptors IFNAR2, IFNGR1 and IFNGR2.

Place, publisher, year, edition, pages
Huddinge: Institutionen för livsvetenskaper , 2007. , 14 p.
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:sh:diva-1274OAI: oai:DiVA.org:sh-1274DiVA: diva2:15338
Uppsok
fysik/kemi/matematik
Supervisors
Examiners
Available from: 2007-06-28 Created: 2007-06-28

Open Access in DiVA

fulltext(340 kB)550 downloads
File information
File name FULLTEXT01.pdfFile size 340 kBChecksum MD5
e4d39f00a87b95afdd811777b67373a25660be6f0503aae0da7d2a4a00992e9c7dd00dc4
Type fulltextMimetype application/pdf

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf