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Identification of the metallo-beta-lactamase gene from clinical isolates of Bacteroides fragilis
Södertörn University, Avdelning Naturvetenskap. Karolinska Institutet.
Karolinska Institutet.
Södertörn University, Avdelning Naturvetenskap. Karolinska Instiutet.
Karolinska Institutet.
1999 (English)In: Anaerobe, ISSN 1075-9964, E-ISSN 1095-8274, Vol. 5, no 3-4, p. 431-434Article in journal (Refereed) Published
Abstract [en]

Bacteroides fragilis is one of the organisms known to produce carbapenem-hydrolysing metallo-beta-lactamase, which can confer resistance to a wide variety of beta-lactams. The purpose of this study was to identify carbapenem-hydrolysing metallo-beta-lactamase-producing B. fragilis strains by means of PCR assay, nucleotide sequencing and enzyme inhibition studies. Ten beta-lactam-resistant B. fragilis isolates were investigated. Four imipenem-resistant strains among the 10 isolates gave positive reactions in the PCR assay. The nucleotide sequences of the PCR products from two imipenem-resistant strains shared >98% similarity with the metallo-beta-lactamase gene from B. fragilis TAL 3636, which was used as a control. The amino acid sequence homology between the two imipenem-resistant strains and B. fragilis TAL 3636 was 99.2%. These strains produced high amounts of Zn2+-dependent beta-lactamases which were inactivated by EDTA.

Place, publisher, year, edition, pages
1999. Vol. 5, no 3-4, p. 431-434
Keywords [en]
Bacteroides fragilis, metallo-beta-lactamase, imipenum-resistance
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:sh:diva-35664DOI: 10.1006/anae.1999.0235ISI: 000085624200082Scopus ID: 2-s2.0-0033141221OAI: oai:DiVA.org:sh-35664DiVA, id: diva2:1223391
Available from: 2018-06-25 Created: 2018-06-25 Last updated: 2018-06-25Bibliographically approved

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Edlund, Charlotta

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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  • Other style
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  • de-DE
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