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Chronic Physical Conditions, Multimorbidity, and Mild Cognitive Impairment in Low- and Middle-Income Countries
Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain / Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.ORCID iD: 0000-0002-9565-5004
entro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain / Universidad Autónoma de Madrid, Madrid, Spain.
South London and Maudsley National Health Service Foundation Trust, London, UK / King's College London, London, UK / Anglia Ruskin University, Chelmsford, UK.
Federal University of Ceará, Fortaleza, Brazil.
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2018 (English)In: Journal of The American Geriatrics Society, ISSN 0002-8614, E-ISSN 1532-5415, Vol. 66, no 4, p. 721-727Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To assess the association between chronic physical conditions and multimorbidity and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs).

DESIGN: Nationally representative, cross-sectional, community-based study.

SETTING: Six countries that participated in the World Health Organization Study on Global Ageing and Adult Health.

PARTICIPANTS: Individuals aged 50 and older (N=32,715; mean age 62.1 ± 15.6; 51.7% female).

MEASUREMENTS: The definition of MCI was based on the recommendations of the National Institute on Ageing and Alzheimer's Association. Ten chronic conditions were assessed (angina pectoris, arthritis, asthma, cataract, chronic lung disease, diabetes mellitus, edentulism, hearing problems, hypertension, stroke). Multivariable logistic regression analysis was conducted to assess the association between chronic physical conditions, multimorbidity (≥2 chronic conditions), and MCI.

RESULTS: The prevalence of multimorbidity was 49.8% (95% confidence interval (CI)=48.1-51.5%) and of MCI was 15.3% (95% CI=14.4-16.3%). After adjustment for potential confounders, edentulism (odds ratio (OR)=1.24), arthritis (OR=1.24), chronic lung disease (OR=1.29), cataract (OR=1.33), stroke (OR=1.94), hearing problems (OR=2.27), and multimorbidity (OR=1.40) were significantly associated with MCI. There was a gradual increase in the likelihood of MCI (1 condition: OR=1.21, 95% CI=1.03-1.42; ≥4 conditions: OR=2.07, 95% CI=1.70-2.52).

CONCLUSION: These results highlight the need to investigate the underlying mechanisms linking chronic conditions and MCI and whether prevention or treatment of chronic conditions or multimorbidity can reduce the onset of cognitive decline and subsequent dementia, especially in LMICs.

Place, publisher, year, edition, pages
2018. Vol. 66, no 4, p. 721-727
Keywords [en]
chronic physical conditions, low- and middle-income countries, mild cognitive impairment, multimorbidity
National Category
Sociology
Identifiers
URN: urn:nbn:se:sh:diva-34620DOI: 10.1111/jgs.15288ISI: 000430300800014PubMedID: 29427504Scopus ID: 2-s2.0-85041722415OAI: oai:DiVA.org:sh-34620DiVA, id: diva2:1183149
Available from: 2018-02-15 Created: 2018-02-15 Last updated: 2018-05-21Bibliographically approved

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Koyanagi, AiStickley, Andrew

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